{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:28:53Z","timestamp":1792790933196,"version":"4.5.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Endometriosis (EMS) is a chronic inflammatory disease characterized by the presence of extrauterine endometrial tissues. It has been previously reported that the refluxed blood containing viable endometrial tissues and the defective elimination of peritoneal macrophages in the pelvic cavity may involve in EMS pathogenesis. However, the mechanism by which macrophages exhibit attenuated phagocytic capability in EMS remains undetermined. Herein, we found that heme, the byproduct of lysed erythrocytes, accumulated abnormally in the peritoneal fluid (PF) of patients with EMS (14.22\u2009\u03bcmol\/L, 95% confidence interval (CI): 12.54\u201316.71), compared with the EMS-free group (9.517\u2009\u03bcmol\/L, 95% CI: 8.891\u201310.1053). This abnormal accumulation was not associated with the color of PF, phase of the menstrual cycle or severity of the disease. The reduced phagocytic ability of peritoneal macrophages (pM\u03c6s) was observed in the EMS group. Consistently, a high-concentration (30\u2009\u03bcmol\/L) heme treatment impaired EMS-pM\u03c6s phagocytosis more than a low-concentration (10\u2009\u03bcmol\/L) heme treatment. A similar phenomenon was observed in the EMS-free control pM\u03c6s (Ctrl-pM\u03c6s) and the CD14+ peripheral monocytes (CD14+ Mos). These results indicated that a high heme concentration exhibits a negative effect on macrophage phagocytosis, which supplements the mechanism of impaired scavenger function of pM\u03c6s in EMS.<\/jats:p>","DOI":"10.1530\/rep-19-0028","type":"journal-article","created":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T10:28:36Z","timestamp":1562927316000},"page":"257-266","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":38,"title":["Elevated heme impairs macrophage phagocytosis in endometriosis"],"prefix":"10.1093","volume":"158","author":[{"given":"Yu-Yin","family":"Liu","sequence":"first","affiliation":[{"name":"Laboratory for Reproductive Immunology , Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Kai","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory for Reproductive Immunology , Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Ting","family":"Hu","sequence":"additional","affiliation":[{"name":"Laboratory for Reproductive Immunology , Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Li","family":"Tang","sequence":"additional","affiliation":[{"name":"Laboratory for Reproductive Immunology , Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ran","family":"Sheng","sequence":"additional","affiliation":[{"name":"Laboratory for Reproductive Immunology , Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Yan","family":"Wei","sequence":"additional","affiliation":[{"name":"Laboratory for Reproductive Immunology , Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Qing","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory for Reproductive Immunology , Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, People\u2019s Republic of China"},{"name":"NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research) , Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, People\u2019s Republic of China"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases , Shanghai, People\u2019s Republic of 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