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The aim of this article is to explore the relationship between miRNA and MA. The expression of miR-98 were detected by in situ hybridization and real-time PCR. Cell proliferation, activity and migration were measured via Edu, MTT, and transwell assays. The target genes of miR-98 are identified by dual-luciferase activity assay. And the expression levels of target genes were determined by Western blot, real-time PCR and immunohistochemistry. miR-98 was significantly up-regulated in placental villi from over 35 years old MA patients compared with the age-matched normal pregnant women. Up-regulation of miR-98 suppressed the proliferation, activity and migration of the human trophoblast HTR-8\/SVneo cell in vitro. miR-98 could bind to GDF6 and FAPP2 mRNA 3\u2019-UTR and negatively regulate their expression. The downregulation of miR-98 promoted cell proliferation, then knockdown of GDF6 or FAPP2 inhibited miR-98-mediated cell proliferation. GDF6 and FAPP2 expression in the placental villi from MA patients were decreased compared to normal placental tissues. The expression of miR-98 in MA had an opposite relationship with the expression of GDF6 and FAPP2. Overexpression of miR-98 is associated with the occurrence of MA. miR-98 prevents proliferation, viability and migration of trophoblast cells partially through targeting GDF6 and FAPP2.<\/jats:p>","DOI":"10.1530\/rep-19-0282","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T11:02:15Z","timestamp":1581332535000},"page":"525-537","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":16,"title":["<i>miR-98<\/i>\n                    is involved in missed abortion by targeting\n                    <i>GDF6<\/i>\n                    and\n                    <i>FAPP2<\/i>"],"prefix":"10.1093","volume":"159","author":[{"given":"Qi","family":"Zhu","sequence":"first","affiliation":[{"name":"Reproductive and Genetic Center of National Research Institute for Family Planning , Beijing, China"},{"name":"Graduate Schools , Peking Union Medical College , Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chao","family":"Dong","sequence":"additional","affiliation":[{"name":"Reproductive and Genetic Center of National Research Institute for Family Planning , Beijing, China"},{"name":"Graduate Schools , Peking Union Medical College , Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Reproductive and Genetic Center of National Research Institute for Family Planning , Beijing, China"},{"name":"Graduate Schools , Peking Union Medical College , Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Ma","sequence":"additional","affiliation":[{"name":"Reproductive and Genetic Center of National Research Institute for Family Planning , Beijing, China"},{"name":"Graduate Schools , Peking Union Medical College , Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Fei","family":"Xia","sequence":"additional","affiliation":[{"name":"Reproductive and Genetic Center of National Research Institute for Family Planning , Beijing, China"},{"name":"Graduate Schools , Peking Union Medical College , Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,1]]},"reference":[{"key":"2026010712223083300_bib1","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1086\/511280","article-title":"GDF6, a novel locus for a spectrum of ocular developmental anomalies","volume":"80","author":"Asai-Coakwell","year":"2007","journal-title":"American Journal of Human Genetics"},{"key":"2026010712223083300_bib2","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.cellsig.2010.10.003","article-title":"Bone morphogenetic proteins: a critical review","volume":"23","author":"Bragdon","year":"2011","journal-title":"Cellular Signalling"},{"key":"2026010712223083300_bib3","first-page":"5419","article-title":"Immunohistochemical analyses of estrogen receptor in endometrial adenocarcinoma using a monoclonal antibody","volume":"46","author":"Budwit-Novotny","year":"1986","journal-title":"Cancer Research"},{"key":"2026010712223083300_bib4","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1093\/humupd\/2.2.118","article-title":"Reproductive failure due to spontaneous abortion and recurrent miscarriage","volume":"2","author":"Bulletti","year":"1996","journal-title":"Human Reproduction Update"},{"key":"2026010712223083300_bib5","doi-asserted-by":"crossref","first-page":"28227","DOI":"10.1016\/S0021-9258(18)46918-9","article-title":"Cartilage-derived morphogenetic proteins. 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