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The expression of leptin in normal trophoblastic cells is regulated by different endogenous signals. We have previously reported that 17\u03b2-estradiol upregulates placental leptin expression through genomic and non-genomic mechanisms. To improve the knowledge of estrogen receptor mechanisms in regulating leptin gene expression, we examined transcription nuclear factor kappa B (NF\u03baB) effect on estradiol leptin induction in human BeWo cell line and human term placental explants. We demonstrated that estradiol induction effect on leptin expression is blocked by the inhibition of NF\u03baB signaling. We also found that the overexpression of p65 subunit, the active form of NF\u03baB, induces leptin expression. Moreover, downregulation of estrogen receptor alpha (ER\u03b1), through a specific siRNA, abolished NF\u03baB effect on leptin expression. We also demonstrated that ER\u03b1 enhanced NF\u03baB signaling pathway activation in trophoblastic cells. Estradiol treatment significantly increased p65 expression and phosphorylation of the inhibitory protein \u03baB alpha (I\u03baB\u03b1). A reporter plasmid containing NF\u03baB elements was also induced in response to estradiol stimulation. Localization experiments revealed that estradiol treatment induced nuclear localization of overexpressed p65. Moreover, the overexpression of ER\u03b1 produced a complete displacement of p65 protein to the nucleus. Finally, immunoprecipitation experiments showed the presence of a complex containing ER\u03b1 and NF\u03baB. All these evidences suggest a cooperative behavior between ER\u03b1 and NF\u03baB transcription factors to induce leptin transcription.<\/jats:p>","DOI":"10.1530\/rep-20-0142","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T12:24:49Z","timestamp":1595334289000},"page":"591-602","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":6,"title":["Crosstalk between estradiol and NF\u03baB signaling pathways on placental leptin expression"],"prefix":"10.1093","volume":"160","author":[{"given":"Malena","family":"Schanton","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Biol\u00f3gica , Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina"},{"name":"Universidad de Buenos Aires , CONICET, Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julieta","family":"Maym\u00f3","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Biol\u00f3gica , Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina"},{"name":"Universidad de Buenos Aires , CONICET, Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Fernanda","family":"Camisay","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Biol\u00f3gica , Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina"},{"name":"Universidad de Buenos Aires , CONICET, Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"P\u00e9rez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica M\u00e9dica y Biolog\u00eda Molecular , Hospital Universitario Virgen Macarena, Facultad de Medicina, Universidad de Sevilla, Sevilla, Espa\u00f1a"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Casale","sequence":"additional","affiliation":[{"name":"Hospital Nacional Profesor Alejandro Posadas , Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edctor","family":"S\u00e1nchez-Margalet","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica M\u00e9dica y Biolog\u00eda Molecular , Hospital Universitario Virgen Macarena, Facultad de Medicina, Universidad de Sevilla, Sevilla, Espa\u00f1a"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra","family":"Erlejman","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Biol\u00f3gica , Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina"},{"name":"Universidad de Buenos Aires , CONICET, Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Varone","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Biol\u00f3gica , Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina"},{"name":"Universidad de Buenos Aires , CONICET, Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,10,1]]},"reference":[{"key":"2026010712230877200_bib1","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.placenta.2005.04.005","article-title":"Suppression of extravillous trophoblast invasion of uterine spiral arteries by estrogen during early baboon pregnancy","volume":"27","author":"Albrecht","year":"2006","journal-title":"Placenta"},{"key":"2026010712230877200_bib2","doi-asserted-by":"publisher","first-page":"34601","DOI":"10.1074\/jbc.M205172200","article-title":"Transcriptional activation of the human leptin gene in response to hypoxia. 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