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In this way, we analyzed the impairments of maternal and paternal high ethanol consumption during postpuberty on the physical development, feeding pattern, puberty onset and reproductive function of ethanol-naive offspring to birth to adulthood. Female and male UChB rats (voluntary 10%, v\/v ethanol consumer) were divided into a control group (C) and an ethanol exposed group (E) from 65 to 80 days of age. The C and E were mated at 100 days. The maternal parameters and offspring development and reproduction parameters were monitored. We observed reduced feeding intake and body weight in the dams of E group throughout gestation and lactation period. Delay in physical development, lower body weight and altered feeding pattern were observed in female and male offspring of E group. In addition, the puberty onset was delayed in both sexes, with lower testosterone levels in the juvenile and pubertal males. There was a prolongation on the estrous and proestrus phases in females from E but the estrous cycle duration did not change between groups. Ovary and uterus weight were reduced in pubertal and adult females from E group. Reduced epididymis and seminal vesicle weight, increased sperm abnormalities, decrease in the daily sperm production and accelerated epididymal transit time were observed in E males. The high maternal and paternal ethanol use on postpuberty impairs the parameters of ethanol-naive offspring inducing alteration on development and reproduction.<\/jats:p>","DOI":"10.1530\/rep-20-0316","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T13:51:19Z","timestamp":1608817879000},"page":"195-204","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":3,"title":["Parents ethanol use impairs ethanol-naive offspring development and reproduction"],"prefix":"10.1093","volume":"161","author":[{"given":"Vanessa Caroline","family":"Fioravante","sequence":"first","affiliation":[{"name":"Department of Structural and Functional Biology , Institute of Biosciences of Botucatu (IBB), UNESP \u2013 Univ Estadual Paulista, S\u00e3o Paulo, Brazil"},{"name":"General and Applied Biology Program , Institute of Biosciences of Botucatu (IBB), UNESP \u2013 Univ Estadual Paulista, S\u00e3o Paulo, 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