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This study examined the potentials of orlistat in attenuating erectile dysfunction and fertility decline in high-fat diet (HFD)-induced obesity in male rats. Eighteen adult male Sprague\u2013Dawley rats whose weights were between 250 and 300 g were divided into three groups (n\u2009=\u20096\/group) namely: normal control (NC), HFD and HFD\u2009+\u2009orlistat (10 mg\/kg body weight\/day co-administered for 12 weeks) (HFD+O). During the 11th and 12th week, mating behaviour and fertility parameters were evaluated, and parameters of glucose metabolism were assessed at the end of the 12th week. Orlistat increased testicular mRNA levels of glucose transporters (Glut1 and Glut3), monocarboxylate transporters (Mct2 and Mct4) and lactate dehydrogenase type C (Ldhc), decreased intratesticular lactate and glucose levels, and LDH activity in obese rats. Furthermore, orlistat increased superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and glutathione reductase (GR) activities, and total antioxidant capacity (TAC), but decreased malondialdehyde level in the penis of obese rats. Similarly, orlistat improved penile cGMP level, sexual behaviour and fertility outcome in obese rats. Penile cGMP level correlated positively with total mounts and intromissions but correlated negatively with mount\/intromission ratio. Orlistat improves fertility potential in obese state by targeting testicular lactate metabolism, penile oxidative stress and sexual behaviour in rats. Therefore, orlistat shows a promising protective effect and may preserve the fertility potential of obese men.<\/jats:p>","DOI":"10.1530\/rep-20-0381","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T18:36:46Z","timestamp":1599849406000},"page":"863-872","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":17,"title":["Orlistat reverses intratesticular lactate transport decline and infertility in male obese rats"],"prefix":"10.1093","volume":"160","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0629-7621","authenticated-orcid":false,"given":"Joseph Bagi","family":"Suleiman","sequence":"first","affiliation":[{"name":"Department of Physiology , School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia"},{"name":"Department of Science Laboratory Technology , Akanu Ibiam Federal Polytechnic, Unwana, Afikpo, Ebonyi State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7616-9468","authenticated-orcid":false,"given":"Victor Udo","family":"Nna","sequence":"additional","affiliation":[{"name":"Department of Physiology , Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, P.M.B, Calabar, Cross River State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaida","family":"Zakaria","sequence":"additional","affiliation":[{"name":"Department of Physiology , School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaidatul Akmal","family":"Othman","sequence":"additional","affiliation":[{"name":"Department of Physiology , School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia"},{"name":"Unit of Physiology , Faculty of Medicine, Universiti Sultan Zainal Abidin, Kuala 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