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Although overfeeding to promote rapid maternal growth robustly leads to a reduction in average birthweight relative to slow-growing control-fed adolescents of equivalent age, the extent of prenatal compromise is variable. This retrospective analysis of a large cohort of identically managed pregnancies determined whether maternal anthropometry predicts the severity of fetal growth-restriction (FGR) in growing adolescents. Singleton pregnancies were established by embryo transfer in adolescents subsequently control-fed (n = 96) or overnourished. The latter pregnancies were classified as non-FGR (n = 116) or FGR (n = 96) if lamb birthweight was above or below the optimally fed control mean minus 2SD. A similar approach categorised placental growth-restriction (PlGR) and preterm delivery. Gestation length, placental mass and lamb birthweight were FGR &amp;lt; non-FGR &amp;lt; control (post hoc P &amp;lt; 0.01). Relative to the non-FGR group, overnourished dams with FGR were marginally leaner and lighter at conception (P = 0.023\/P = 0.014) and had greater gestational weight gain (GWG) during the first-third of pregnancy (P &amp;lt; 0.001). GWG during this early period was also higher in PlGR compared with non-PlGR, and in very preterm vs term deliveries (P &amp;lt; 0.01). Likewise maternal leptin concentrations (fat accrual biomarker) were FGR &amp;gt; non-FGR by day 60, and changes in leptin throughout pregnancy predicted attenuated fetal cotyledon mass and birthweight (P = 0.01 to &amp;lt;0.001). The anthropometric antecedents of FGR in still-growing adolescent sheep originate in early pregnancy coincident with early placental development.<\/jats:p>","DOI":"10.1530\/rep-20-0533","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T09:49:49Z","timestamp":1607075389000},"page":"227-238","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":4,"title":["Early pregnancy weight gain and fat accrual predict pregnancy outcome in growing adolescent sheep"],"prefix":"10.1093","volume":"161","author":[{"given":"Jacqueline M","family":"Wallace","sequence":"first","affiliation":[{"name":"Rowett Institute , University of Aberdeen, Aberdeen, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John S","family":"Milne","sequence":"additional","affiliation":[{"name":"Rowett Institute , University of Aberdeen, Aberdeen, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond P","family":"Aitken","sequence":"additional","affiliation":[{"name":"Rowett Institute , University of Aberdeen, Aberdeen, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,3,1]]},"reference":[{"key":"2026010712055873400_bib1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665111004678","article-title":"Influence of birth weight, sex, age and adiposity on central leptin and insulin sensitivity in young growing sheep, as indicated by changes in voluntary food intake","volume":"70","author":"Adam","year":"2011","journal-title":"Proceedings of the Nutrition Society"},{"key":"2026010712055873400_bib2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2017.00144","article-title":"Effect of fetal sex on maternal and obstetric outcomes","volume":"5","author":"Al-Qaraghouli","year":"2017","journal-title":"Frontiers in 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