{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:44:49Z","timestamp":1787964289500,"version":"build-2784847793"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T00:00:00Z","timestamp":1636934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The objective of this study was to evaluate the effect of accessory corpus luteum (CL) induction on fertility in dairy cows. On day 5 after artificial insemination (AI), lactating Holstein cows were assigned unequally to receive gonadotrophin-releasing hormone treatment (GnRH) (n\u2009= 641) or no treatment (control; n\u2009\u2009= 289). Cows had their blood sampled for progesterone (P4), and ovaries were scanned by ultrasound on days 5, 12, 19, 26, 33, 47, and 61 after AI. Pregnancy diagnosis was performed on days 26, 33, 47, and 61. On day 12, cows treated with GnRH were allocated to ipsilateral (n\u2009= 239) or contralateral (n\u2009= 241) groups based on the side of accessory CL formation relative to previous ovulation. Accessory CL cows had greater P4 than controls. In total, 52.7% (78\/148) of pregnant cows in contralateral group had accessory CL regression earlier (&amp;lt;day 33; 30.8%) or later (days 33\u201361; 69.2%) in pregnancy with coincident decrease in P4. No cows with ipsilateral accessory CL underwent regression. There was no difference in pregnancy\/AI among groups. Cows with contralateral accessory CL that underwent early regression had greater pregnancy loss (30%) than controls (10%), or cows with ipsilateral CL (3%) or contralateral CL with either later or no regression (12%). Cows with ipsilateral accessory CL had lower pregnancy loss than controls. In conclusion, elevating circulating P4 by the induction of accessory CL, particularly ipsilateral CL, increases P4 and reduces pregnancy loss. However, contralateral accessory CL that undergoes regression before day 33 of pregnancy has increased pregnancy loss, possibly due to an abrupt decrease in P4 at a pivotal period of pregnancy (days 26\u201333).<\/jats:p>","DOI":"10.1530\/rep-21-0168","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T10:47:03Z","timestamp":1636973223000},"page":"483-495","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":8,"title":["Accessory corpus luteum regression during pregnancy II: reproductive outcomes"],"prefix":"10.1093","volume":"162","author":[{"given":"Pedro L J","family":"Monteiro","sequence":"first","affiliation":[{"name":"Department of Animal Science , University of S\u00e3o Paulo, Piracicaba, S\u00e3o Paulo, Brazil"},{"name":"Department of Animal and Dairy Sciences , University of Wisconsin-Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0935-9234","authenticated-orcid":false,"given":"Caio A","family":"Gamarra","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences , University of Wisconsin-Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo S","family":"Genari","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences , University of Wisconsin-Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre B","family":"Prata","sequence":"additional","affiliation":[{"name":"Department of Animal Science , University of S\u00e3o Paulo, Piracicaba, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael V","family":"Barletta","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences , University of Wisconsin-Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peregrino G","family":"Duran","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences , University of Wisconsin-Madison, Madison, Wisconsin, USA"},{"name":"Reproductive Biotechnology Laboratory , Philippine Carabao Center, Mu\u00f1oz, Nueva Ecija, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurea M O","family":"Canavessi","sequence":"additional","affiliation":[{"name":"Department of Animal Science , University of S\u00e3o Paulo, Piracicaba, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Sartori","sequence":"additional","affiliation":[{"name":"Department of Animal Science , University of S\u00e3o Paulo, Piracicaba, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milo C","family":"Wiltbank","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences , University of Wisconsin-Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,11,15]]},"reference":[{"key":"2026010712070294300_bib1","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1016\/j.theriogenology.2015.04.022","article-title":"Effect of uterine size on fertility of lactating dairy cows","volume":"85","author":"Baez","year":"2016","journal-title":"Theriogenology"},{"key":"2026010712070294300_bib2","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.theriogenology.2016.09.055","article-title":"Proposal of a new model for CL regression or maintenance during pregnancy on the basis of timing of regression of contralateral, accessory CL in pregnant cows","volume":"89","author":"Baez","year":"2017","journal-title":"Theriogenology"},{"key":"2026010712070294300_bib3","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.theriogenology.2009.06.018","article-title":"Evaluation of models to induce low progesterone during the early luteal phase in cattle","volume":"72","author":"Beltman","year":"2009","journal-title":"Theriogenology"},{"key":"2026010712070294300_bib4","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/s0093-691x(0200935-4","article-title":"Morphology and morphometry of in vivo- and in vitro-produced bovine concepti from early pregnancy to term and association with high birth weights","volume":"58","author":"Bertolini","year":"2002","journal-title":"Theriogenology"},{"key":"2026010712070294300_bib5","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1071\/rd07204","article-title":"Effect of increasing progesterone concentration from day 3 of pregnancy on subsequent embryo survival and development in beef heifers","volume":"20","author":"Carter","year":"2008","journal-title":"Reproduction, Fertility, and Development"},{"key":"2026010712070294300_bib6","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/0093-691x(9490117-2","article-title":"Prostaglandin E2 levels in uterine tissues and its relationship with uterine and luteal progesterone during the estrous cycle in dairy cows","volume":"42","author":"Cerbito","year":"1994","journal-title":"Theriogenology"},{"key":"2026010712070294300_bib7","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1016\/0093-691X(9490831-3","article-title":"Spatial-distribution of progesterone in bovine uterus in relation to corpus-luteum location and function","volume":"41","author":"Cerbito","year":"1994","journal-title":"Theriogenology"},{"key":"2026010712070294300_bib8","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/j.1439-0531.1997.tb01275.x","article-title":"Evidence for uterine horn differences in local concentrations of oxytocin, oxytocin receptor and prostaglandin F-2 alpha during the estrous cycle and early pregnancy in cows","volume":"32","author":"Cerbito","year":"1997","journal-title":"Reproduction in Domestic Animals"},{"key":"2026010712070294300_bib9","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1530\/REP-09-0152","article-title":"Progesterone and conceptus elongation in cattle: a direct effect on the embryo or an indirect effect via the endometrium?","volume":"138","author":"Clemente","year":"2009","journal-title":"Reproduction"},{"key":"2026010712070294300_bib10","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.anireprosci.2006.08.008","article-title":"Embryo survival in dairy cows managed under pastoral conditions","volume":"96","author":"Diskin","year":"2006","journal-title":"Animal Reproduction Science"},{"key":"2026010712070294300_bib11","doi-asserted-by":"publisher","first-page":"9238","DOI":"10.3168\/jds.2015-10383","article-title":"Prediction of portal and hepatic blood flow from intake level data in cattle","volume":"99","author":"Ellis","year":"2016","journal-title":"Journal of Dairy Science"},{"key":"2026010712070294300_bib12","doi-asserted-by":"publisher","first-page":"2695","DOI":"10.3168\/jds.S0022-0302(9477212-X","article-title":"Principal descriptors of body condition score in Holstein cows","volume":"77","author":"Ferguson","year":"1994","journal-title":"Journal of Dairy Science"},{"key":"2026010712070294300_bib13","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1152\/physiolgenomics.00162.2009","article-title":"Effect of pregnancy and progesterone concentration on expression of genes encoding for transporters or secreted proteins in the bovine endometrium","volume":"41","author":"Forde","year":"2010","journal-title":"Physiological Genomics"},{"key":"2026010712070294300_bib14","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1095\/biolreprod.110.085910","article-title":"Changes in the endometrial transcriptome during the bovine estrous cycle: effect of low circulating progesterone and consequences for conceptus elongation","volume":"84","author":"Forde","year":"2011","journal-title":"Biology of Reproduction"},{"key":"2026010712070294300_bib15","first-page":"478","article-title":"Selected amino acid transporters are altered in the bovine endometrium and conceptus during the pre-implantation period of pregnancy and are modulated by altered progesterone concentrations in vivo","volume":"47","author":"Forde","year":"2012","journal-title":"Reproduction in Domestic Animals"},{"key":"2026010712070294300_bib16","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1111\/rda.12703","article-title":"Pregnancy loss in dairy cattle: relationship of ultrasound, blood pregnancy-specific protein B, progesterone and production variables","volume":"51","author":"Gabor","year":"2016","journal-title":"Reproduction in Domestic Animals"},{"key":"2026010712070294300_bib17","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.theriogenology.2019.05.010","article-title":"Postovulatory treatment with GnRH on day 5 reduces pregnancy loss in recipients receiving an in vitro produced expanded blastocyst","volume":"141","author":"Garcia-Guerra","year":"2020","journal-title":"Theriogenology"},{"key":"2026010712070294300_bib18","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1071\/rd9920301","article-title":"Endocrine events associated with endometrial function and conceptus development in cattle","volume":"4","author":"Geisert","year":"1992","journal-title":"Reproduction, Fertility, and Development"},{"key":"2026010712070294300_bib19","doi-asserted-by":"publisher","first-page":"2749","DOI":"10.3168\/jds.S0022-0302(9078960-6","article-title":"Increased milk production versus reproductive and energy status of high-producing dairy cows","volume":"73","author":"Harrison","year":"1990","journal-title":"Journal of Dairy Science"},{"key":"2026010712070294300_bib20","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.anireprosci.2005.10.010","article-title":"Conception rates and serum progesterone concentration in dairy cattle administered gonadotropin releasing hormone 5 days after artificial insemination","volume":"95","author":"Howard","year":"2006","journal-title":"Animal Reproduction Science"},{"key":"2026010712070294300_bib21","doi-asserted-by":"publisher","first-page":"386","DOI":"10.2527\/jas1958.172386x","article-title":"Effect of progesterone administration on reproductive efficiency","volume":"17","author":"Johnson","year":"1958","journal-title":"Journal of Animal Science"},{"key":"2026010712070294300_bib22","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.anireprosci.2007.02.023","article-title":"Pregnancy rates in lactating dairy cattle following supplementation of progesterone after artificial insemination","volume":"102","author":"Larson","year":"2007","journal-title":"Animal Reproduction Science"},{"key":"2026010712070294300_bib23","doi-asserted-by":"publisher","first-page":"8698","DOI":"10.3168\/jds.2020-18583","article-title":"Symposium review: Progesterone effects on early embryo development in cattle","volume":"103","author":"Lonergan","year":"2020","journal-title":"Journal of Dairy Science"},{"key":"2026010712070294300_bib24","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.3168\/jds.S0022-0302(0572958-1","article-title":"Relationship between level of milk production and multiple ovulations in lactating dairy cows","volume":"88","author":"Lopez","year":"2005","journal-title":"Journal of Dairy Science"},{"key":"2026010712070294300_bib25","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.tvjl.2004.12.005","article-title":"Effects of time of progesterone supplementation on embryo development and interferon-tau production in the cow","volume":"171","author":"Mann","year":"2006","journal-title":"Veterinary Journal"},{"key":"2026010712070294300_bib26","doi-asserted-by":"publisher","first-page":"3031","DOI":"10.3168\/jds.2015-10595","article-title":"Associations between pregnancy-associated glycoproteins and pregnancy outcomes, milk yield, parity, and clinical diseases in high-producing dairy cows","volume":"99","author":"Mercadante","year":"2016","journal-title":"Journal of Dairy Science"},{"key":"2026010712070294300_bib27","doi-asserted-by":"publisher","first-page":"4907","DOI":"10.3168\/jds.2013-7802","article-title":"Effects of supplemental progesterone after artificial insemination on expression of interferon-stimulated genes and fertility in dairy cows","volume":"97","author":"Monteiro","year":"2014","journal-title":"Journal of Dairy Science"},{"key":"2026010712070294300_bib28","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1016\/j.theriogenology.2015.06.023","article-title":"Progesterone supplementation after ovulation: effects on corpus luteum function and on fertility of dairy cows subjected to AI or ET","volume":"84","author":"Monteiro","year":"2015","journal-title":"Theriogenology"},{"key":"2026010712070294300_bib50","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1530\/REP-21-0167","article-title":"Accessory corpus luteum regression during pregnancy I: Timing, physiology, and P4 profiles","author":"Monteiro","year":"2021","journal-title":"Reproduction"},{"key":"2026010712070294300_bib29","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.3168\/jds.S0022-0302(0174600-0","article-title":"Effects of presynchronization and bovine somatotropin on pregnancy rates to a timed artificial insemination protocol in lactating dairy cows","volume":"84","author":"Moreira","year":"2001","journal-title":"Journal of Dairy Science"},{"key":"2026010712070294300_bib30","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1071\/RD12104","article-title":"Effects of treatment with human chorionic gonadotrophin or intravaginal progesterone-releasing device after AI on circulating progesterone concentrations in lactating dairy cows","volume":"25","author":"Nascimento","year":"2013","journal-title":"Reproduction, Fertility, and Development"},{"key":"2026010712070294300_bib31","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.3168\/jds.2012-5895","article-title":"Effect of treatment with human chorionic gonadotropin on day 5 after timed artificial insemination on fertility of lactating dairy cows","volume":"96","author":"Nascimento","year":"2013","journal-title":"Journal of Dairy Science"},{"key":"2026010712070294300_bib32","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.3168\/jds.2018-15588","article-title":"Effect of treatment with human chorionic gonadotropin 7 days after artificial insemination or at the time of embryo transfer on reproductive outcomes in nulliparous Holstein heifers","volume":"102","author":"Niles","year":"2019","journal-title":"Journal of Dairy Science"},{"key":"2026010712070294300_bib51","doi-asserted-by":"publisher","author":"NRC","year":"2001","DOI":"10.17226\/9825"},{"key":"2026010712070294300_bib33","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/0034-5288(9390100-t","article-title":"Liver blood-flow and metabolic-clearance rate of progesterone in sheep","volume":"55","author":"Parr","year":"1993","journal-title":"Research in Veterinary Science"},{"key":"2026010712070294300_bib34","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.3168\/jds.2011-4498","article-title":"Relationship between pregnancy per artificial insemination and early luteal concentrations of progesterone and establishment of repeatability estimates for these traits in Holstein-Friesian heifers","volume":"95","author":"Parr","year":"2012","journal-title":"Journal of Dairy Science"},{"key":"2026010712070294300_bib35","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/0093-691x(9500279-h","article-title":"Synchronization of ovulation in dairy-cows using PGF(2-alpha), and GnRH","volume":"44","author":"Pursley","year":"1995","journal-title":"Theriogenology"},{"key":"2026010712070294300_bib36","doi-asserted-by":"publisher","first-page":"10526","DOI":"10.3168\/jds.2018-14495","article-title":"Effect of equine chorionic gonadotropin treatment during a progesterone-based timed artificial insemination program on reproductive performance in seasonal-calving lactating dairy cows","volume":"101","author":"Randi","year":"2018","journal-title":"Journal of Dairy Science"},{"key":"2026010712070294300_bib37","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1095\/biolreprod.113.114694","article-title":"Low doses of bovine somatotropin enhance conceptus development and fertility in lactating dairy cows","volume":"90","author":"Ribeiro","year":"2014","journal-title":"Biology of Reproduction"},{"key":"2026010712070294300_bib38","doi-asserted-by":"publisher","first-page":"6556","DOI":"10.3168\/jds.2017-14058","article-title":"Effect of human chorionic gonadotrophin administration 2 days after insemination on progesterone concentration and pregnancy per artificial insemination in lactating dairy cows","volume":"101","author":"Sanchez","year":"2018","journal-title":"Journal of Dairy Science"},{"key":"2026010712070294300_bib39","doi-asserted-by":"publisher","first-page":"2831","DOI":"10.3168\/jds.S0022-0302(0274370-1","article-title":"High feed intake increases liver blood flow and metabolism of progesterone and estradiol-17 beta in dairy cattle","volume":"85","author":"Sangsritavong","year":"2002","journal-title":"Journal of Dairy Science"},{"key":"2026010712070294300_bib40","doi-asserted-by":"publisher","first-page":"2881","DOI":"10.2527\/2001.79112881x","article-title":"Effect of human chorionic gonadotropin, on luteal function and reproductive performance of high-producing lactating Holstein dairy cows","volume":"79","author":"Santos","year":"2001","journal-title":"Journal of Animal Science"},{"key":"2026010712070294300_bib41","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.3168\/jds.S0022-0302(0274368-3","article-title":"Ovarian structures and circulating steroids in heifers and lactating cows in summer and lactating and dry cows in winter","volume":"85","author":"Sartori","year":"2002","journal-title":"Journal of Dairy Science"},{"key":"2026010712070294300_bib42","doi-asserted-by":"publisher","first-page":"905","DOI":"10.3168\/jds.S0022-0302(0473235-X","article-title":"Comparison of ovarian function and circulating steroids in estrous cycles of Holstein heifers and lactating cows","volume":"87","author":"Sartori","year":"2004","journal-title":"Journal of Dairy Science"},{"key":"2026010712070294300_bib43","doi-asserted-by":"publisher","first-page":"e0189117","DOI":"10.1371\/journal.pone.0189117","article-title":"Effect of feeding rumen-protected methionine on productive and reproductive performance of dairy cows","volume":"12","author":"Toledo","year":"2017","journal-title":"PLoS ONE"},{"key":"2026010712070294300_bib44","doi-asserted-by":"publisher","first-page":"RESEARCH0034","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biology"},{"key":"2026010712070294300_bib45","doi-asserted-by":"publisher","first-page":"456","DOI":"10.3168\/jds.S0022-0302(5694769-5","article-title":"Effect of progesterone therapy on embryo survival in cows of lowered fertility","volume":"39","author":"Wiltbank","year":"1956","journal-title":"Journal of Dairy Science"},{"key":"2026010712070294300_bib46","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.theriogenology.2005.10.003","article-title":"Changes in reproductive physiology of lactating dairy cows due to elevated steroid metabolism","volume":"65","author":"Wiltbank","year":"2006","journal-title":"Theriogenology"},{"issue":"Supplement 1","key":"2026010712070294300_bib47","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1017\/S1751731114000585","article-title":"Physiological and practical effects of progesterone on reproduction in dairy cattle","volume":"8","author":"Wiltbank","year":"2014","journal-title":"Animal"},{"key":"2026010712070294300_bib48","doi-asserted-by":"publisher","first-page":"1390.e1","DOI":"10.1016\/j.theriogenology.2015.12.027","article-title":"Efficacy of progesterone supplementation during early pregnancy in cows: a meta-analysis","volume":"85","author":"Yan","year":"2016","journal-title":"Theriogenology"},{"key":"2026010712070294300_bib49","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/1471-2105-7-85","article-title":"Statistical analysis of real-time PCR data","volume":"7","author":"Yuan","year":"2006","journal-title":"BMC Bioinformatics"}],"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rep.bioscientifica.com\/view\/journals\/rep\/162\/6\/REP-21-0168.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/162\/6\/483\/64063602\/rep-21-0168.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/162\/6\/483\/64063602\/rep-21-0168.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T17:07:06Z","timestamp":1767805626000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/162\/6\/483\/8216945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,15]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12,1]]}},"URL":"https:\/\/doi.org\/10.1530\/rep-21-0168","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,12,1]]},"published":{"date-parts":[[2021,11,15]]}}}