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However, how and why these abnormalities occur remain to be defined. In this study, pregnancy at different stages was compared between 25- and 30- day-old and mature female mice. We found that the litter size of adolescent pregnancy is significantly decreased from F1 to F3 generations compared to mature pregnancy. On days 8 and 12 of pregnancy, multiple abnormalities in decidual and placental development appear in F3 adolescent pregnancy. On days 5 and 8, uterine endoplasmic reticulum stress is dysregulated in F3 adolescent pregnancy. Embryo implantation and decidualization are also compromised in adolescent pregnancy. Many genes are abnormally expressed in adolescent estrous uteri. The abnormal endocrine environment and abnormal implantation from uterine immaturity may result in multiple pregnancy failures in adolescent pregnancy. The aim of this study is to shed light on human adolescent pregnancy.<\/jats:p>","DOI":"10.1530\/rep-21-0240","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T08:30:53Z","timestamp":1630917053000},"page":"353-365","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":3,"title":["Female reproductive abnormalities in mouse adolescent pregnancy"],"prefix":"10.1093","volume":"162","author":[{"given":"Chen","family":"Yang","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine , South China Agricultural University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine , South China Agricultural University, Guangzhou, 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