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However, the pathologic effects of U. parvum in the cervix, which prevents ascending infections during pregnancy, are still poorly understood. To determine the impact of U. parvum on the cervix, ectocervical (ecto) and endocervical (endo) epithelial and stromal cells were incubated with U. parvum. Macrophages were also tested as a proxy for cervical macrophages to determine the antigenicity of U. parvum. The effects of U. parvum, including influence on cell cycle and cell death, antimicrobial peptide (AMP) production, epithelial-to-mesenchymal transition (EMT), and inflammatory cytokine levels, were assessed. U. parvum colonized cervical epithelial and stromal cells 4 h post-infection. Like uninfected control, U. parvum neither inhibited cell cycle progression and nor caused cell death in cervical epithelial and stromal cells. U. parvum increased the production of the AMPs cathelicidin and human \u03b2-defensin 3 and exhibited weak signs of EMT evidenced by decreased cytokeratin 18 and increased vimentin expression in cervical epithelial cells. U. parvum induced a proinflammatory environment (cytokines) and increased MMP-9 in cervical epithelial cells but promoted pro- and anti-inflammatory response in cervical stromal cells and macrophages. U. parvum may colonize the cervical epithelial layer, but induction of AMPs and anti-inflammatory response may protect the cervix and may prevent ascending infections that can cause PTB. These findings suggest that U. parvum is a weak inducer of inflammation in the cervix.<\/jats:p>","DOI":"10.1530\/rep-21-0308","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T13:27:57Z","timestamp":1636982877000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":20,"title":["Inflammatory response elicited by\n                    <i>Ureaplasma parvum<\/i>\n                    colonization in human cervical epithelial, stromal, and immune cells"],"prefix":"10.1093","volume":"163","author":[{"given":"Ourlad Alzeus G","family":"Tantengco","sequence":"first","affiliation":[{"name":"Division of Basic and Translational Research , Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA"},{"name":"Biological Models Laboratory , Department of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines Manila, Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talar","family":"Kechichian","sequence":"additional","affiliation":[{"name":"Division of Basic and Translational Research , Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen L","family":"Vincent","sequence":"additional","affiliation":[{"name":"Division of Basic and Translational Research , Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B","family":"Pyles","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , University of Texas Medical Branch, Galveston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Mark 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