{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:11:41Z","timestamp":1787508701333,"version":"build-2736575974"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Decidualization of uterine stromal cells plays an important role in the establishment of normal pregnancy. Previous studies have demonstrated that Acyl-CoA binding protein (Acbp) is critical to cellular proliferation, differentiation, mitochondrial functions, and autophagy. The characterization and physiological function of Acbp during decidualization remain largely unknown. In the present study, we conducted the expression profile of Acbp in the endometrium of early pregnant mice. With the occurrence of decidualization, the expression of Acbp gradually increased. Similarly, Acbp expression was also strongly expressed in decidualized cells following artificial decidualization, both in vivo and in vitro. We applied the mice pseudopregnancy model to reveal that the expression of Acbp in the endometrium of early pregnant mice was not induced by embryonic signaling. Moreover, P4 significantly upregulated the expression of Acbp, whereas E2 appeared to have no regulating effect on Acbp expression in uterine stromal cells. Concurrently, we found that interfering with Acbp attenuated decidualization, and that might due to mitochondrial dysfunctions and the inhibition of fatty acid oxidation. The level of autophagy was increased after knocking down Acbp. During induced decidualization, the expression of ACBP was decreased with the treatment of rapamycin (an autophagy inducer), while increased with the addition of Chloroquine (an autophagy inhibitor). Our work suggests that Acbp plays an essential role in the proliferation and differentiation of stromal cells during decidualization through regulating mitochondrial functions, fatty acid oxidation, and autophagy.<\/jats:p>","DOI":"10.1530\/rep-21-0430","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T13:54:47Z","timestamp":1647006887000},"page":"309-321","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":3,"title":["<i>Acbp<\/i>\n                    is essential for decidualization during early pregnancy in mice"],"prefix":"10.1093","volume":"163","author":[{"given":"Xue","family":"Zhang","sequence":"first","affiliation":[{"name":"Laboratory of Reproductive Biology , School of Public Health and Management, Chongqing Medical University, Chongqing , People\u2019s Republic of China"},{"name":"The Joint International Research Laboratory of Reproduction and Development , Ministry of Education, Chongqing Medical University, Chongqing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Yin","family":"Tan","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive Biology , School of Public Health and Management, Chongqing Medical University, Chongqing , People\u2019s Republic of China"},{"name":"The Joint International Research Laboratory of Reproduction and Development , Ministry of Education, Chongqing Medical University, Chongqing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Joint International Research Laboratory of Reproduction and Development , Ministry of Education, Chongqing Medical University, Chongqing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Gynecology , Chongqing Hospital of Traditional Chinese Medicine, Chongqing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Bai","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive Biology , School of Public Health and Management, Chongqing Medical University, Chongqing , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Quan","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine , The Third affiliated hospital of Chongqing Medical University, Chongqing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Mei","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive Biology , School of Public Health and Management, Chongqing Medical University, Chongqing , People\u2019s Republic of China"},{"name":"The Joint International Research Laboratory of Reproduction and Development , Ministry of Education, Chongqing Medical University, Chongqing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Lin","family":"He","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive Biology , School of Public Health and Management, Chongqing Medical University, Chongqing , People\u2019s Republic of China"},{"name":"The Joint International Research Laboratory of Reproduction and Development , Ministry of Education, Chongqing Medical University, Chongqing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive Biology , School of Public Health and Management, Chongqing Medical University, Chongqing , People\u2019s Republic of China"},{"name":"The Joint International Research Laboratory of Reproduction and Development , Ministry of Education, Chongqing Medical University, Chongqing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Xiong","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive Biology , School of Public Health and Management, Chongqing Medical University, Chongqing , People\u2019s Republic of China"},{"name":"The Joint International Research Laboratory of Reproduction and Development , Ministry of Education, Chongqing Medical University, Chongqing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Bin","family":"Ding","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive Biology , School of Public Health and Management, Chongqing Medical University, Chongqing , People\u2019s Republic of China"},{"name":"The Joint International Research Laboratory of Reproduction and Development , Ministry of Education, Chongqing Medical University, Chongqing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0401-3517","authenticated-orcid":false,"given":"Fang-Fang","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive Biology , School of Public Health and Management, Chongqing Medical University, Chongqing , People\u2019s Republic of China"},{"name":"The Joint International Research Laboratory of Reproduction and Development , Ministry of Education, Chongqing Medical University, Chongqing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"key":"2026010712083638500_bib1","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1096\/fj.11-184663","article-title":"Notch1 mediates uterine stromal differentiation and is critical for complete decidualization in the mouse","volume":"26","author":"Afshar","year":"2012","journal-title":"FASEB Journal"},{"key":"2026010712083638500_bib2","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1530\/REP-16-0364","article-title":"The endocannabinoid anandamide impairs in vitro decidualization of human cells","volume":"152","author":"Almada","year":"2016","journal-title":"Reproduction"},{"key":"2026010712083638500_bib3","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.ydbio.2006.03.006","article-title":"Post-implantation mouse conceptuses produce paracrine signals that regulate the uterine endometrium undergoing decidualization","volume":"294","author":"Bany","year":"2006","journal-title":"Developmental Biology"},{"key":"2026010712083638500_bib4","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1023\/b:jarg.0000027018.02425.15","article-title":"Why do older women have poor implantation rates? A possible role of the mitochondria","volume":"21","author":"Bartmann","year":"2004","journal-title":"Journal of Assisted Reproduction and Genetics"},{"key":"2026010712083638500_bib5","doi-asserted-by":"publisher","first-page":"2687","DOI":"10.1242\/dev.122.9.2687","article-title":"Mechanisms of reduced fertility in Hoxa-10 mutant mouse: uterine homeosis and loss of maternal Hoxa-10 expression","volume":"122","author":"Benson","year":"1996","journal-title":"Development"},{"key":"2026010712083638500_bib6","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.bbalip.2013.09.013","article-title":"Acyl-CoA binding protein and epidermal barrier function","volume":"1841","author":"Bloksgaard","year":"2014","journal-title":"Biochimica et Biophysica Acta"},{"key":"2026010712083638500_bib7","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1038\/nm.3012","article-title":"Mechanisms of implantation: strategies for successful pregnancy","volume":"18","author":"Cha","year":"2012","journal-title":"Nature Medicine"},{"key":"2026010712083638500_bib8","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1016\/j.cell.2006.06.010","article-title":"Mitochondria: dynamic organelles in disease, aging, and development","volume":"125","author":"Chan","year":"2006","journal-title":"Cell"},{"key":"2026010712083638500_bib9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003863","article-title":"Activin-like kinase 2 functions in peri-implantation uterine signaling in mouse and humans","volume":"9","author":"Clementi","year":"2013","journal-title":"PLoS Genetics"},{"key":"2026010712083638500_bib10","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1385\/1-59259-983-4:007","article-title":"Methodologies to study implantation in mice","volume":"121","author":"Deb","year":"2006","journal-title":"Methods in Molecular Medicine"},{"key":"2026010712083638500_bib11","doi-asserted-by":"publisher","first-page":"2704","DOI":"10.1210\/en.2014-1015","article-title":"Regulation and function of deiodinases during decidualization in female mouse","volume":"155","author":"Deng","year":"2014","journal-title":"Endocrinology"},{"key":"2026010712083638500_bib12","doi-asserted-by":"publisher","first-page":"274.e5","DOI":"10.1016\/j.cmet.2019.04.004","article-title":"Acyl-CoA-binding protein drives glioblastoma tumorigenesis by sustaining fatty acid oxidation","volume":"30","author":"Duman","year":"2019","journal-title":"Cell Metabolism"},{"key":"2026010712083638500_bib13","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/S0022-2275(2032401-9","article-title":"Long-chain acyl-CoA esters and acyl-CoA binding protein are present in the nucleus of rat liver cells","volume":"41","author":"Elholm","year":"2000","journal-title":"Journal of Lipid Research"},{"key":"2026010712083638500_bib14","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.rbmo.2016.11.009","article-title":"Stomatin-like protein 2 is involved in endometrial stromal cell proliferation and differentiation during decidualization in mouse and humans","volume":"34","author":"Feng","year":"2017","journal-title":"Reproductive Biomedicine Online"},{"key":"2026010712083638500_bib15","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1073\/pnas.83.3.827","article-title":"Study of an octadecaneuropeptide derived from diazepam binding inhibitor (DBI): biological activity and presence in rat brain","volume":"83","author":"Ferrero","year":"1986","journal-title":"PNAS"},{"key":"2026010712083638500_bib16","first-page":"897","article-title":"Accuracy of the spatial localization of the sources of brain bioelectrical activity in a model homogeneous unrestricted environment","volume":"38","author":"Frolov","year":"1988","journal-title":"Zhurnal Vysshei Nervnoi Deiatelnosti Imeni I P Pavlova"},{"key":"2026010712083638500_bib17","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1210\/er.2014-1045","article-title":"Cyclic decidualization of the human endometrium in reproductive health and failure","volume":"35","author":"Gellersen","year":"2014","journal-title":"Endocrine Reviews"},{"key":"2026010712083638500_bib18","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1158\/1940-6207.CAPR-14-0057","article-title":"Acyl-coenzyme A-binding protein regulates beta-oxidation required for growth and survival of non-small cell lung cancer","volume":"7","author":"Harris","year":"2014","journal-title":"Cancer Prevention Research"},{"key":"2026010712083638500_bib19","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1210\/endo-125-3-1683","article-title":"Cell type-specific localization of c-myc protein in the mouse uterus: modulation by steroid hormones and analysis of the periimplantation period","volume":"125","author":"Huet-Hudson","year":"1989","journal-title":"Endocrinology"},{"key":"2026010712083638500_bib20","doi-asserted-by":"publisher","first-page":"4426","DOI":"10.1016\/S0021-9258(1834740-9","article-title":"The asymmetric distribution of charges on the surface of horse cytochrome c. Functional implications","volume":"257","author":"Koppenol","year":"1982","journal-title":"Journal of Biological Chemistry"},{"key":"2026010712083638500_bib21","doi-asserted-by":"publisher","first-page":"2792","DOI":"10.1080\/15384101.2016.1220459","article-title":"Hmgn5 functions downstream of Hoxa10 to regulate uterine decidualization in mouse","volume":"15","author":"Li","year":"2016","journal-title":"Cell Cycle"},{"key":"2026010712083638500_bib22","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.2147\/IJN.S92257","article-title":"Novel walnut peptide-selenium hybrids with enhanced anticancer synergism: facile synthesis and mechanistic investigation of anticancer activity","volume":"11","author":"Liao","year":"2016","journal-title":"International Journal of Nanomedicine"},{"key":"2026010712083638500_bib23","doi-asserted-by":"publisher","first-page":"9351","DOI":"10.1074\/jbc.M511512200","article-title":"Serial analysis of gene expression in mouse uterus at the implantation site","volume":"281","author":"Ma","year":"2006","journal-title":"Journal of Biological Chemistry"},{"key":"2026010712083638500_bib24","doi-asserted-by":"publisher","first-page":"3918","DOI":"10.2174\/1381612824666181112111746","article-title":"Neuroprotection with the endozepine octadecaneuropeptide, ODN","volume":"24","author":"Masmoudi-Kouki","year":"2018","journal-title":"Current Pharmaceutical Design"},{"key":"2026010712083638500_bib25","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1182\/blood-2008-12-195883","article-title":"Differential expression of NADPH oxidases in megakaryocytes and their role in polyploidy","volume":"114","author":"McCrann","year":"2009","journal-title":"Blood"},{"key":"2026010712083638500_bib26","doi-asserted-by":"publisher","first-page":"902","DOI":"10.4161\/cc.8.6.7900","article-title":"Upregulation of Nox4 in the aging vasculature and its association with smooth muscle cell polyploidy","volume":"8","author":"McCrann","year":"2009","journal-title":"Cell Cycle"},{"key":"2026010712083638500_bib27","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20123066","article-title":"Decreased autophagy impairs decidualization of human endometrial stromal cells: a role for ATG proteins in endometrial physiology","volume":"20","author":"Mestre Citrinovitz","year":"2019","journal-title":"International Journal of Molecular Sciences"},{"key":"2026010712083638500_bib28","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1172\/JCI44723","article-title":"Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mouse","volume":"121","author":"Mori","year":"2011","journal-title":"Journal of Clinical Investigation"},{"key":"2026010712083638500_bib29","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/s0015-0282(1654069-2","article-title":"The window of embryo transfer and the efficiency of human conception in vitro","volume":"55","author":"Navot","year":"1991","journal-title":"Fertility and Sterility"},{"key":"2026010712083638500_bib30","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1056\/NEJMra000763","article-title":"Implantation and the survival of early pregnancy","volume":"345","author":"Norwitz","year":"2001","journal-title":"New England Journal of Medicine"},{"key":"2026010712083638500_bib31","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/nature20791","article-title":"Targeting metastasis-initiating cells through the fatty acid receptor CD36","volume":"541","author":"Pascual","year":"2017","journal-title":"Nature"},{"key":"2026010712083638500_bib32","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.1080\/15548627.2019.1662585","article-title":"Cell-autonomous, paracrine and neuroendocrine feedback regulation of autophagy by DBI\/ACBP (diazepam binding inhibitor, acyl-CoA binding protein): the obesity factor","volume":"15","author":"Pedro","year":"2019","journal-title":"Autophagy"},{"key":"2026010712083638500_bib33","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1055\/s-0029-1242989","article-title":"Endometrial decidualization: of mouse and men","volume":"28","author":"Ramathal","year":"2010","journal-title":"Seminars in Reproductive Medicine"},{"key":"2026010712083638500_bib34","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1071\/rd00046","article-title":"Genes involved in implantation","volume":"13","author":"Salamonsen","year":"2001","journal-title":"Reproduction, Fertility, and Development"},{"key":"2026010712083638500_bib35","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.2741\/s347","article-title":"Developmental regulation of decidual cell polyploidy at the site of implantation","volume":"4","author":"Sroga","year":"2012","journal-title":"Frontiers in Bioscience"},{"issue":"Supplement 3","key":"2026010712083638500_bib36","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1111\/j.1439-0531.2009.01402.x","article-title":"Role of fatty acids in energy provision during oocyte maturation and early embryo development","volume":"44","author":"Sturmey","year":"2009","journal-title":"Reproduction in Domestic Animals"},{"key":"2026010712083638500_bib37","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/s00109-019-01849-y","article-title":"Endometrial autophagy is essential for embryo implantation during early pregnancy","volume":"98","author":"Su","year":"2020","journal-title":"Journal of Molecular Medicine"},{"key":"2026010712083638500_bib38","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1158\/0008-5472.CAN-16-1645","article-title":"Bone marrow adipocytes facilitate fatty acid oxidation activating AMPK and a transcriptional network supporting survival of acute monocytic leukemia cells","volume":"77","author":"Tabe","year":"2017","journal-title":"Cancer Research"},{"key":"2026010712083638500_bib39","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.ydbio.2003.09.019","article-title":"HB-EGF directs stromal cell polyploidy and decidualization via cyclin D3 during implantation","volume":"265","author":"Tan","year":"2004","journal-title":"Developmental Biology"},{"key":"2026010712083638500_bib40","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/0022-510x(8990139-1","article-title":"Normal muscle CPT1 and CPT2 activities in hepatic presentation patients with CPT1 deficiency in fibroblasts. Tissue specific isoforms of CPT1?","volume":"92","author":"Tein","year":"1989","journal-title":"Journal of the Neurological Sciences"},{"key":"2026010712083638500_bib41","doi-asserted-by":"publisher","first-page":"107386","DOI":"10.1016\/j.pharmthera.2019.06.008","article-title":"Endozepines and their receptors: structure, functions and pathophysiological significance","volume":"208","author":"Tonon","year":"2020","journal-title":"Pharmacology and Therapeutics"},{"key":"2026010712083638500_bib42","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.113.113217","article-title":"The fatty acid beta-oxidation pathway is important for decidualization of endometrial stromal cells in both humans and mouse","volume":"90","author":"Tsai","year":"2014","journal-title":"Biology of Reproduction"},{"key":"2026010712083638500_bib43","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/nrg1808","article-title":"Roadmap to embryo implantation: clues from mouse models","volume":"7","author":"Wang","year":"2006","journal-title":"Nature Reviews: Genetics"},{"key":"2026010712083638500_bib44","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.112.104687","article-title":"Wnt6 is essential for stromal cell proliferation during decidualization in mouse","volume":"88","author":"Wang","year":"2013","journal-title":"Biology of Reproduction"},{"key":"2026010712083638500_bib45","doi-asserted-by":"publisher","first-page":"3459","DOI":"10.7150\/jca.31742","article-title":"Role of endometrial autophagy in physiological and pathophysiological processes","volume":"10","author":"Yang","year":"2019","journal-title":"Journal of Cancer"},{"key":"2026010712083638500_bib46","doi-asserted-by":"publisher","first-page":"3497","DOI":"10.3892\/or.2017.6044","article-title":"Expression of fatty acid synthase is regulated by PGC1alpha and contributes to increased cell proliferation","volume":"38","author":"Yun","year":"2017","journal-title":"Oncology Reports"},{"key":"2026010712083638500_bib47","doi-asserted-by":"publisher","first-page":"2339","DOI":"10.1093\/humrep\/dew191","article-title":"nm23 regulates decidualization through the PI3K-Akt-mTOR signaling pathways in mouse and humans","volume":"31","author":"Zhang","year":"2016","journal-title":"Human Reproduction"},{"key":"2026010712083638500_bib48","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1210\/en.2012-2026","article-title":"The coregulator, repressor of estrogen receptor activity (REA), is a crucial regulator of the timing and magnitude of uterine decidualization","volume":"154","author":"Zhao","year":"2013","journal-title":"Endocrinology"}],"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rep.bioscientifica.com\/view\/journals\/rep\/163\/5\/REP-21-0430.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/163\/5\/309\/64064176\/rep-21-0430.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/163\/5\/309\/64064176\/rep-21-0430.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T17:08:41Z","timestamp":1767805721000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/163\/5\/309\/8217105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,29]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5,1]]}},"URL":"https:\/\/doi.org\/10.1530\/rep-21-0430","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,5,1]]},"published":{"date-parts":[[2022,3,29]]}}}