{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:01:30Z","timestamp":1780498890443,"version":"3.54.1"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":1163,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>\u2003<\/jats:title>\n                  <jats:sec>\n                    <jats:title>In brief<\/jats:title>\n                    <jats:p>Xenografts of human ovarian cortical tissue provide a tractable model of heterotopic autotransplantation that is used for fertility preservation in patients undergoing ablative chemo\/radiotherapy. This study describes the behavior of hundreds of xenografts to establish a framework for the clinical function of ovarian cortex following autotransplantation over short- and long-term intervals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>More than 200 live births have been achieved using autotransplantation of cryopreserved ovarian cortical fragments, yet challenges remain to be addressed. Ischemia of grafted tissue undermines viability and longevity, typically requiring transplantation of multiple cortical pieces; and the dynamics of recruitment within a graft and the influence of parameters like size and patient age at the time of cryopreservation are not well-defined. Here, we describe results from a series of experiments in which we xenografted frozen\/thawed human ovarian tissue (n\u2009\u2009=\u2009440) from 28 girls and women (age range 32 weeks gestational age to 46 years, median 24.3 \u00b1 4.6). Xenografts were recovered across a broad range of intervals (1\u201352 weeks post-transplantation) and examined histologically to quantify follicle density and distribution. The number of antral follicles in xenografted cortical fragments correlated positively with the total follicle number and was significantly reduced with increased patient age. Within xenografts, follicles were distributed in focal clusters, similar to the native ovary, but the presence of a leading antral follicle coincided with increased proliferation of surrounding follicles. These results underscore the importance of transplanting ovarian tissue with a high density of follicles and elucidate a potential paracrine influence of leading antral follicles on neighboring follicles of earlier stages. This temporal framework for interpreting the kinetics of follicle growth\/mobilization may be useful in setting expectations and guiding the parameters of clinical autotransplantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/rep-22-0114","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T11:39:03Z","timestamp":1664883543000},"page":"31-47","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":11,"title":["Xenograft model of heterotopic transplantation of human ovarian cortical tissue and its clinical relevance"],"prefix":"10.1093","volume":"165","author":[{"given":"Limor","family":"Man","sequence":"first","affiliation":[{"name":"Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine and Infertility , Weill Cornell Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Lustgarten Guahmich","sequence":"additional","affiliation":[{"name":"Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine and Infertility , Weill Cornell Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Kallinos","sequence":"additional","affiliation":[{"name":"Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine and Infertility , Weill Cornell Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Park","sequence":"additional","affiliation":[{"name":"Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine and Infertility , Weill Cornell Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Bodine","sequence":"additional","affiliation":[{"name":"Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine and Infertility , Weill Cornell Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikica","family":"Zaninovic","sequence":"additional","affiliation":[{"name":"Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine and Infertility , Weill Cornell Medicine, New York, New York, USA"},{"name":"Tri-Institutional Stem Cell Derivation Laboratory , Weill Cornell Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Schattman","sequence":"additional","affiliation":[{"name":"Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine and Infertility , Weill Cornell Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zev","family":"Rosenwaks","sequence":"additional","affiliation":[{"name":"Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine and Infertility , Weill Cornell Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0975-2554","authenticated-orcid":false,"given":"Daylon","family":"James","sequence":"additional","affiliation":[{"name":"Ronald O. 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