{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:45:38Z","timestamp":1788345938592,"version":"build-2803163510"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,4,1]]},"abstract":"<jats:title>\u2003<\/jats:title>\n                  <jats:sec>\n                    <jats:title>In brief<\/jats:title>\n                    <jats:p>miR-23b-3p expression is increased in fertile endometrium during receptivity. This study investigates the function of miR-23b-3p on endometrial adhesion and its downstream targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>The human endometrium undergoes dramatic remodeling throughout the menstrual cycle that is essential for successful blastocyst attachment and implantation in the mid-secretory (receptive) phase. microRNA (miR) plays a role in the preparation of endometrial receptivity. miR-23b-3p expression is increased in fertile endometrium during receptivity. Here, we aimed to investigate miR-23b-3p function during receptivity. qPCR and in situ hybridization were used to investigate the expression and localization of miR-23b-3p in human endometrium, respectively. Ishikawa cells (endometrial epithelial cell line) and endometrial organoid-derived epithelial cells were transfected with miR-23b-3p mimic, and trophoblast progenitor spheroid (blastocyst surrogate) adhesion assay was used to determine effects on blastocyst adhesion to endometrial cells. We demonstrated that miR-23b-3p was significantly upregulated in the fertile endometrium of the receptive phase compared to the non-receptive, proliferative phase. No difference was identified for the expression of miR-23b-3p between fertile and infertile mid-secretory phase endometrium. miR-23b-3p localized to the epithelium and stroma in the mid-secretory phase but was undetectable in the proliferative phase of fertile endometrium. Functionally, miR-23-3p overexpression in Ishikawa cells and fertile endometrial organoid-derived epithelial cells significantly improved their adhesive capacity to trophoblast progenitor spheroids. miR-23b-3p overexpression in infertile endometrial organoid-derived epithelial cells did not improve adhesion. Among 10 miR-predicted gene targets examined, miR-23b-3p overexpression in Ishikawa cells significantly reduced the expression of MET, secreted frizzled-related protein 4 (SFRP4) and acyl-CoA dehydrogenase short\/branched chain (ACADSB) compared to control. The reduction of SFRP4 after miR23b-3p overexpression was confirmed by immunoblotting in fertile organoid-derived epithelial cells. SFRP4 expression in fertile endometrium exhibited an inverse expression pattern compared to miR-23b-3p and was higher in the proliferative phase compared to the mid-secretory phase. Overall, miR-23b-3p is likely a critical regulator of endometrial epithelial adhesion and receptivity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/rep-22-0338","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T10:01:38Z","timestamp":1675936898000},"page":"407-416","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":11,"title":["miR-23b-3p regulates human endometrial epithelial cell adhesion implying a role in implantation"],"prefix":"10.1093","volume":"165","author":[{"given":"Siena","family":"Barton","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology , University of Melbourne, Parkville, Victoria, Australia"},{"name":"Gynaecology Research Centre , Royal Women's Hospital, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9636-7963","authenticated-orcid":false,"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology , University of Melbourne, Parkville, Victoria, Australia"},{"name":"Gynaecology Research Centre , Royal Women's Hospital, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leilani L","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology , University of Melbourne, Parkville, Victoria, Australia"},{"name":"Gynaecology Research Centre , Royal Women's Hospital, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Menkhorst","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology , University of Melbourne, Parkville, Victoria, Australia"},{"name":"Gynaecology Research Centre , Royal Women's Hospital, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guannan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology , University of Melbourne, Parkville, Victoria, Australia"},{"name":"Gynaecology Research Centre , Royal Women's Hospital, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan","family":"Tinn Teh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology , University of Melbourne, Parkville, Victoria, Australia"},{"name":"The Royal Women\u2019s Hospital , Parkville, VIC, Australia"},{"name":"Melbourne IVF , Melbourne, VIC, Australia"},{"name":"Epworth HealthCare , Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Ang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology , University of Melbourne, Parkville, Victoria, Australia"},{"name":"The Royal Women\u2019s Hospital , Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarana","family":"Lucky","sequence":"additional","affiliation":[{"name":"The Royal Women\u2019s Hospital , Parkville, VIC, Australia"},{"name":"Faculty of Medicine Dentistry&Health Sciences , University of Melbourne, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1425-950X","authenticated-orcid":false,"given":"Evdokia","family":"Dimitriadis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology , University of Melbourne, Parkville, Victoria, Australia"},{"name":"Gynaecology Research Centre , Royal Women's Hospital, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,8]]},"reference":[{"key":"2026021212273438100_bib1","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1053\/beog.2000.0116","article-title":"The cell biological basis of human implantation","volume":"14","author":"Aplin","year":"2000","journal-title":"Bailliere\u2019s Best Practice and Research. 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