{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T07:43:04Z","timestamp":1781163784322,"version":"3.54.1"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":805,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:title>\u2003<\/jats:title>\n                  <jats:sec>\n                    <jats:title>In brief<\/jats:title>\n                    <jats:p>The establishment and maintenance of embryo implantation and pregnancy require decidualization of endometrial stromal cells. This paper reveals that SHP2 ensures the correct subcellular localization of progesterone receptor, thereby safeguarding the process of decidualization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Decidualization is the process of conversion of endometrial stromal cells into decidual stromal cells, which is caused by progesterone production that begins during the luteal phase of the menstrual cycle and then increases throughout pregnancy dedicated to support embryonic development. Decidualization deficiency is closely associated with various pregnancy complications, such as recurrent miscarriage (RM). Here, we reported that Src-homology-2-containing phospho-tyrosine phosphatase (SHP2), a key regulator in the signal transduction process downstream of various receptors, plays an indispensable role in decidualization. SHP2 expression was upregulated during decidualization. SHP2 inhibitor RMC-4550 and shRNA-mediated SHP2 reduction resulted in a decreased level of phosphorylation of ERK and aberrant cytoplasmic localization of progesterone receptor (PR), coinciding with reduced expression of IGFBP1 and various other target genes of decidualization. Solely inhibiting ERK activity recapitulated these observations. Administration of RMC-4550 led to decidualization deficiency and embryo absorption in mice. Moreover, reduced expression of SHP2 was detected in the decidua of RM patients. Our results revealed that SHP2 is key to PR's nuclear localization, thereby indispensable for decidualization and that reduced expression of SHP2 might be engaged in the pathogenesis of RM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/rep-22-0367","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T10:10:21Z","timestamp":1684145421000},"page":"37-53","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":7,"title":["SHP2 participates in decidualization by activating ERK to maintain normal nuclear localization of progesterone receptor"],"prefix":"10.1093","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0775-1777","authenticated-orcid":false,"given":"Lin","family":"Chen","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine , Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine , Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China"},{"name":"Laboratory for Reproductive Immunology , NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxiong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynaecology , Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazhu","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine , Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzi","family":"Tian","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine , Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Edmond H. Fischer Translational Medical Research Laboratory , Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguang","family":"Chang","sequence":"additional","affiliation":[{"name":"Edmond H. Fischer Translational Medical Research Laboratory , Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzhe","family":"Zhang","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences and Medicine , Kings College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4323-4301","authenticated-orcid":false,"given":"Zhizhuang Joe","family":"Zhao","sequence":"additional","affiliation":[{"name":"Edmond H. Fischer Translational Medical Research Laboratory , Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China"},{"name":"Department of Pathology , University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8348-8755","authenticated-orcid":false,"given":"Yun","family":"Chen","sequence":"additional","affiliation":[{"name":"Edmond H. Fischer Translational Medical Research Laboratory , Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8545-3380","authenticated-orcid":false,"given":"Lin","family":"Ma","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine , Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"2026010712100659500_bib1","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.jsbmb.2013.12.008","article-title":"Post-translational modifications of the progesterone receptors","volume":"140","author":"Abdel-Hafiz","year":"2014","journal-title":"Journal of Steroid Biochemistry and Molecular Biology"},{"key":"2026010712100659500_bib2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20164068","article-title":"Left ventricular hypertrophy: roles of mitochondria CYP1B1 and melatonergic pathways in Co-ordinating wider pathophysiology","volume":"20","author":"Anderson","year":"2019","journal-title":"International Journal of Molecular Sciences"},{"key":"2026010712100659500_bib3","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11091381","article-title":"BRAF mutations Classes I, II, and III in NSCLC patients included in the SLLIP trial: the need for a new pre-clinical treatment rationale","volume":"11","author":"Bracht","year":"2019","journal-title":"Cancers (Basel)"},{"key":"2026010712100659500_bib4","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments","volume":"55","author":"Bustin","year":"2009","journal-title":"Clinical Chemistry"},{"key":"2026010712100659500_bib5","doi-asserted-by":"publisher","first-page":"4241","DOI":"10.1016\/j.febslet.2010.09.016","article-title":"SHP2 is a downstream target of ZAP70 to regulate JAK1\/STAT3 and ERK signaling pathways in mouse embryonic stem cells","volume":"584","author":"Cha","year":"2010","journal-title":"FEBS Letters"},{"key":"2026010712100659500_bib6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1010018","article-title":"Shp2 in uterine stromal cells critically regulates on time embryo implantation and stromal decidualization by multiple pathways during early pregnancy","volume":"18","author":"Cheng","year":"2022","journal-title":"PLOS Genetics"},{"key":"2026010712100659500_bib7","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/s0303-7207(0100465-8","article-title":"Reproductive functions of the progesterone receptor isoforms: lessons from knock-out mice","volume":"179","author":"Conneely","year":"2001","journal-title":"Molecular and Cellular Endocrinology"},{"key":"2026010712100659500_bib8","doi-asserted-by":"publisher","DOI":"10.3390\/cells11091474","article-title":"Progesterone receptor signaling in the uterus is essential for pregnancy success","volume":"11","author":"Cope","year":"2022","journal-title":"Cells"},{"key":"2026010712100659500_bib9","doi-asserted-by":"publisher","DOI":"10.1530\/JME-19-0274","article-title":"90 years of progesterone: steroid receptors as MAPK signaling sensors in breast cancer: let the fates decide","volume":"65","author":"Dwyer","year":"2020","journal-title":"Journal of Molecular Endocrinology"},{"key":"2026010712100659500_bib10","doi-asserted-by":"publisher","first-page":"E1871","DOI":"10.1210\/jc.2013-1661","article-title":"Increased AKT or MEK1\/2 activity influences progesterone receptor levels and localization in endometriosis","volume":"98","author":"Eaton","year":"2013","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2026010712100659500_bib11","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1111\/jog.13837","article-title":"New insights into the mechanisms underlying recurrent pregnancy loss","volume":"45","author":"Ewington","year":"2019","journal-title":"Journal of Obstetrics and Gynaecology Research"},{"key":"2026010712100659500_bib12","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1158\/2159-8290.CD-18-0444","article-title":"SHP2 inhibition prevents adaptive resistance to MEK inhibitors in multiple cancer models","volume":"8","author":"Fedele","year":"2018","journal-title":"Cancer Discovery"},{"key":"2026010712100659500_bib13","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/sj.cr.7310140","article-title":"Shp2-mediated molecular signaling in control of embryonic stem cell self-renewal and differentiation","volume":"17","author":"Feng","year":"2007","journal-title":"Cell Research"},{"key":"2026010712100659500_bib14","doi-asserted-by":"publisher","first-page":"4744","DOI":"10.1210\/en.2009-0166","article-title":"The protein-tyrosine phosphatase, SRC homology-2 domain containing protein tyrosine phosphatase-2, is a crucial mediator of exogenous insulin-like growth factor signaling to human trophoblast","volume":"150","author":"Forbes","year":"2009","journal-title":"Endocrinology"},{"key":"2026010712100659500_bib15","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1055\/s-2007-991042","article-title":"Decidualization of the human endometrium: mechanisms, functions, and clinical perspectives","volume":"25","author":"Gellersen","year":"2007","journal-title":"Seminars in Reproductive Medicine"},{"key":"2026010712100659500_bib16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinsphys.2021.104198","article-title":"Expression of protein tyrosine phosphatases and Bombyx embryonic development","volume":"130","author":"Gu","year":"2021","journal-title":"Journal of Insect Physiology"},{"key":"2026010712100659500_bib17","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/s0020-7292(0200197-2","article-title":"ACoOa 2002 ACOG practice bulletin. Management of recurrent pregnancy loss. Number 24, February 2001. (Replaces Technical Bulletin Number 212, September 1995)","volume":"78","author":"Gynecologists","year":"1995","journal-title":"International Journal of Gynaecology and Obstetrics"},{"key":"2026010712100659500_bib18","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1158\/1541-7786.MCR-12-0578","article-title":"The tyrosine phosphatase SHP2 regulates focal adhesion kinase to promote EGF-induced lamellipodia persistence and cell migration","volume":"11","author":"Hartman","year":"2013","journal-title":"Molecular Cancer Research"},{"key":"2026010712100659500_bib19","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1007\/s43032-020-00428-8","article-title":"Evaluation of expression and phosphorylation of progesterone receptor in endometrial stromal cells of patients with recurrent implantation failure compared to healthy fertile women","volume":"28","author":"Hosseinirad","year":"2021","journal-title":"Reproductive Sciences"},{"key":"2026010712100659500_bib20","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1080\/09513590.2020.1787378","article-title":"Elevated expressions of SHP2 and GAB2 correlated with VEGF in eutopic and ectopic endometrium of women with ovarian endometriosis","volume":"36","author":"Huang","year":"2020","journal-title":"Gynecological Endocrinology"},{"key":"2026010712100659500_bib21","doi-asserted-by":"publisher","DOI":"10.3390\/cells9081798","article-title":"Growth factors, and cytokines; understanding the role of tyrosine phosphatase SHP2 in gametogenesis and early embryo development","volume":"9","author":"Idrees","year":"2020","journal-title":"Cells"},{"key":"2026010712100659500_bib22","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.648463","article-title":"Heat shock proteins and their role in pregnancy: redefining the function of \"old rum in a new bottle\"","volume":"9","author":"Jee","year":"2021","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"2026010712100659500_bib23","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1158\/1535-7163.MCT-20-0965","article-title":"SHP2 inhibition enhances the effects of tyrosine kinase inhibitors in preclinical models of treatment-naive ALK-, ROS1-, or EGFR-altered non-small cell lung cancer","volume":"20","author":"Kano","year":"2021","journal-title":"Molecular Cancer Therapeutics"},{"key":"2026010712100659500_bib24","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1039\/d1md00386k","article-title":"Recent advances in the discovery of protein tyrosine phosphatase SHP2 inhibitors","volume":"13","author":"Kong","year":"2022","journal-title":"RSC Medicinal Chemistry"},{"key":"2026010712100659500_bib25","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-154","article-title":"New insights into mechanisms behind miscarriage","volume":"11","author":"Larsen","year":"2013","journal-title":"BMC Medicine"},{"key":"2026010712100659500_bib26","doi-asserted-by":"publisher","first-page":"31725","DOI":"10.1074\/jbc.M704723200","article-title":"Bone morphogenetic protein 2 functions via a conserved signaling pathway involving Wnt4 to regulate uterine decidualization in the mouse and the human","volume":"282","author":"Li","year":"2007","journal-title":"Journal of Biological Chemistry"},{"key":"2026010712100659500_bib28","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9050754","article-title":"Evaluation of decalcification techniques for rat femurs using HE and immunohistochemical staining","volume":"2017","author":"Liu","year":"2017","journal-title":"BioMed Research International"},{"key":"2026010712100659500_bib27","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.52322","article-title":"The metalloproteinase Papp-aa controls epithelial cell quiescence-proliferation transition","volume":"9","author":"Liu","year":"2020","journal-title":"eLife"},{"key":"2026010712100659500_bib29","doi-asserted-by":"publisher","first-page":"3908","DOI":"10.1016\/j.apsb.2021.03.037","article-title":"Strategies to overcome drug resistance using SHP2 inhibitors","volume":"11","author":"Liu","year":"2021","journal-title":"Acta Pharmaceutica Sinica. B"},{"key":"2026010712100659500_bib30","doi-asserted-by":"publisher","first-page":"265","DOI":"10.18632\/oncotarget.27435","article-title":"Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR","volume":"11","author":"Lu","year":"2020","journal-title":"Oncotarget"},{"key":"2026010712100659500_bib31","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1093\/biolre\/ioz063","article-title":"Impaired decidualization caused by downregulation of circadian clock gene BMAL1 contributes to human recurrent miscarriage\u2020","volume":"101","author":"Lv","year":"2019","journal-title":"Biology of Reproduction"},{"key":"2026010712100659500_bib32","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-08154-1","article-title":"Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation","volume":"10","author":"Ma","year":"2019","journal-title":"Nature Communications"},{"key":"2026010712100659500_bib33","doi-asserted-by":"publisher","first-page":"Unit18.18","DOI":"10.1002\/0471142727.mb1818s92","article-title":"Serine\/threonine protein phosphatase assays","author":"McAvoy","year":"2010","journal-title":"Current Protocols in Molecular Biology"},{"key":"2026010712100659500_bib34","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1093\/humupd\/dmv060","article-title":"Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics","volume":"22","author":"McKinnon","year":"2016","journal-title":"Human Reproduction Update"},{"key":"2026010712100659500_bib35","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.yjmcc.2010.03.001","article-title":"SHP2 mediates gp130-dependent cardiomyocyte hypertrophy via negative regulation of skeletal alpha-actin gene","volume":"49","author":"Nakaoka","year":"2010","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"2026010712100659500_bib36","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21114092","article-title":"Endometrial decidualization: the primary driver of pregnancy health","volume":"21","author":"Ng","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"key":"2026010712100659500_bib37","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1038\/s41556-018-0169-1","article-title":"RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers","volume":"20","author":"Nichols","year":"2018","journal-title":"Nature Cell Biology"},{"key":"2026010712100659500_bib38","doi-asserted-by":"publisher","DOI":"10.3390\/cells11071096","article-title":"MicroRNAs and progesterone receptor signaling in endometriosis pathophysiology","volume":"11","author":"Nothnick","year":"2022","journal-title":"Cells"},{"key":"2026010712100659500_bib39","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21061973","article-title":"Physiologic events of embryo implantation and decidualization in human and non-human Primates","volume":"21","author":"Ochoa-Bernal","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"key":"2026010712100659500_bib40","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1146\/annurev.immunol.23.021704.115647","article-title":"Nonreceptor protein-tyrosine phosphatases in immune cell signaling","volume":"25","author":"Pao","year":"2007","journal-title":"Annual Review of Immunology"},{"key":"2026010712100659500_bib41","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.fertnstert.2020.12.010","article-title":"Endometrial causes of recurrent pregnancy losses: endometriosis, adenomyosis, and chronic endometritis","volume":"115","author":"Pirtea","year":"2021","journal-title":"Fertility and Sterility"},{"key":"2026010712100659500_bib42","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.112.104414","article-title":"The tyrosine phosphatase SHP2 regulates Sertoli cell junction complexes","volume":"88","author":"Puri","year":"2013","journal-title":"Biology of Reproduction"},{"key":"2026010712100659500_bib43","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1016\/S0140-6736(2100682-6","article-title":"Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss","volume":"397","author":"Quenby","year":"2021","journal-title":"Lancet"},{"key":"2026010712100659500_bib44","doi-asserted-by":"publisher","first-page":"2889","DOI":"10.1158\/0008-5472.CAN-19-3038","article-title":"Allosteric inhibition of SHP2 stimulates antitumor immunity by transforming the immunosuppressive environment","volume":"80","author":"Quintana","year":"2020","journal-title":"Cancer Research"},{"key":"2026010712100659500_bib45","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/S0140-6736(0669204-0","article-title":"Recurrent miscarriage","volume":"368","author":"Rai","year":"2006","journal-title":"Lancet"},{"key":"2026010712100659500_bib46","doi-asserted-by":"publisher","first-page":"4816","DOI":"10.1073\/pnas.1700978114","article-title":"Nuclear Shp2 directs normal embryo implantation via facilitating the ER\u03b1 tyrosine phosphorylation by the Src kinase","volume":"114","author":"Ran","year":"2017","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"2026010712100659500_bib47","doi-asserted-by":"publisher","first-page":"379","DOI":"10.2144\/000113410","article-title":"Adaptation and validation of DNA synthesis detection by fluorescent dye derivatization for high-throughput screening","volume":"48","author":"Ranall","year":"2010","journal-title":"BioTechniques"},{"key":"2026010712100659500_bib48","doi-asserted-by":"publisher","first-page":"C478","DOI":"10.1152\/ajpcell.00004.2016","article-title":"Absence of suppressor of cytokine signaling 2 turns cardiomyocytes unresponsive to LIF-dependent increases in Ca(2+) levels","volume":"312","author":"Rocha-Resende","year":"2017","journal-title":"American Journal of Physiology. Cell Physiology"},{"key":"2026010712100659500_bib49","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1071\/RD11908","article-title":"Novel aspects of endometrial function: a biological sensor of embryo quality and driver of pregnancy success","volume":"24","author":"Sandra","year":"2011","journal-title":"Reproduction, Fertility, and Development"},{"key":"2026010712100659500_bib50","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112117","article-title":"Therapeutic potential of targeting SHP2 in human developmental disorders and cancers","volume":"190","author":"Shen","year":"2020","journal-title":"European Journal of Medicinal Chemistry"},{"key":"2026010712100659500_bib51","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.apsb.2020.07.010","article-title":"Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies","volume":"11","author":"Song","year":"2021","journal-title":"Acta Pharmaceutica Sinica. B"},{"key":"2026010712100659500_bib52","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1261\/rna.2192803","article-title":"Lentivirus-delivered stable gene silencing by RNAi in primary cells","volume":"9","author":"Stewart","year":"2003","journal-title":"RNA"},{"key":"2026010712100659500_bib53","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25274-3","article-title":"Combined intermittent fasting and ERK inhibition enhance the anti-tumor effects of chemotherapy via the GSK3beta-SIRT7 axis","volume":"12","author":"Tang","year":"2021","journal-title":"Nature Communications"},{"key":"2026010712100659500_bib54","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1093\/molehr\/gaq079","article-title":"The molecular basis of recurrent pregnancy loss: impaired natural embryo selection","volume":"16","author":"Teklenburg","year":"2010","journal-title":"Molecular Human Reproduction"},{"key":"2026010712100659500_bib55","doi-asserted-by":"publisher","first-page":"4212","DOI":"10.1091\/mbc.E12-01-0038","article-title":"The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of \u03b2-catenin phosphorylation","volume":"23","author":"Timmerman","year":"2012","journal-title":"Molecular Biology of the Cell"},{"key":"2026010712100659500_bib56","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.jri.2009.12.006","article-title":"Recurrent miscarriage: current concepts in diagnosis and treatment","volume":"85","author":"Toth","year":"2010","journal-title":"Journal of Reproductive Immunology"},{"key":"2026010712100659500_bib57","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1164\/rccm.201602-0329OC","article-title":"SH2 domain-containing Phosphatase-2 is a novel antifibrotic regulator in pulmonary fibrosis","volume":"195","author":"Tzouvelekis","year":"2017","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"2026010712100659500_bib58","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1074\/mcp.M500279-MCP200","article-title":"A human protein atlas for normal and cancer tissues based on antibody proteomics","volume":"4","author":"Uhlen","year":"2005","journal-title":"Molecular and Cellular Proteomics"},{"key":"2026010712100659500_bib59","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"Uhlen","year":"2015","journal-title":"Science"},{"key":"2026010712100659500_bib61","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/859812","article-title":"Protective effects of baicalin on decidua cells of LPS-induced mice abortion","volume":"2014","author":"Wang","year":"2014","journal-title":"Journal of Immunology Research"},{"key":"2026010712100659500_bib60","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1080\/07391102.2019.1613266","article-title":"Probing the acting mode and advantages of RMC-4550 as an Src-homology 2 domain-containing protein tyrosine phosphatase (SHP2) inhibitor at molecular level through molecular docking and molecular dynamics","volume":"38","author":"Wang","year":"2020","journal-title":"Journal of Biomolecular Structure and Dynamics"},{"key":"2026010712100659500_bib62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041424","article-title":"Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos","volume":"7","author":"Weimar","year":"2012","journal-title":"PLOS ONE"},{"key":"2026010712100659500_bib63","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.mce.2015.04.032","article-title":"Lipopolysaccharide-induced murine embryonic resorption involves changes in endocannabinoid profiling and alters progesterone secretion and inflammatory response by a CB1-mediated fashion","volume":"411","author":"Wolfson","year":"2015","journal-title":"Molecular and Cellular Endocrinology"},{"key":"2026010712100659500_bib64","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.devcel.2006.01.002","article-title":"An Shp2\/SFK\/Ras\/Erk signaling pathway controls trophoblast stem cell survival","volume":"10","author":"Yang","year":"2006","journal-title":"Developmental Cell"},{"key":"2026010712100659500_bib65","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1093\/humrep\/der010","article-title":"Abnormal activation of Ras\/Raf\/MAPK and RhoA\/ROCKII signalling pathways in eutopic endometrial stromal cells of patients with endometriosis","volume":"26","author":"Yotova","year":"2011","journal-title":"Human Reproduction"},{"key":"2026010712100659500_bib66","doi-asserted-by":"publisher","first-page":"19382","DOI":"10.1074\/jbc.M200732200","article-title":"ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase","volume":"277","author":"Yu","year":"2002","journal-title":"Journal of Biological Chemistry"},{"key":"2026010712100659500_bib67","doi-asserted-by":"publisher","first-page":"11368","DOI":"10.1021\/acs.jmedchem.0c00249","article-title":"Recent advances of SHP2 inhibitors in cancer therapy: current development and clinical application","volume":"63","author":"Yuan","year":"2020","journal-title":"Journal of Medicinal Chemistry"},{"key":"2026010712100659500_bib68","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3935","article-title":"Tumour-associated mutant p53 drives the Warburg effect","volume":"4","author":"Zhang","year":"2013","journal-title":"Nature Communications"},{"key":"2026010712100659500_bib69","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.mam.2012.12.011","article-title":"Physiological and molecular determinants of embryo implantation","volume":"34","author":"Zhang","year":"2013","journal-title":"Molecular Aspects of Medicine"},{"key":"2026010712100659500_bib72","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1530\/JME-17-0180","article-title":"Downregulation of decidual SP1 and P300 is associated with severe preeclampsia","volume":"60","author":"Zhang","year":"2018","journal-title":"Journal of Molecular Endocrinology"},{"key":"2026010712100659500_bib70","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1111\/imr.13085","article-title":"The metabolic characteristic of decidual immune cells and their unique properties in pregnancy loss","volume":"308","author":"Zhang","year":"2022","journal-title":"Immunological Reviews"},{"key":"2026010712100659500_bib71","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1002\/dvdy.449","article-title":"The role of the protein tyrosine phosphatase SHP2 in ossification","volume":"251","author":"Zhang","year":"2022","journal-title":"Developmental Dynamics"},{"key":"2026010712100659500_bib73","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.841308","article-title":"SHP2 inhibitors show anti-myeloma activity and synergize with bortezomib in the treatment of multiple myeloma","volume":"13","author":"Zhou","year":"2022","journal-title":"Frontiers in Pharmacology"},{"key":"2026010712100659500_bib74","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-018-0862-8","article-title":"ERRalpha suppression enhances the cytotoxicity of the MEK inhibitor trametinib against colon cancer cells","volume":"37","author":"Zhou","year":"2018","journal-title":"Journal of Experimental and Clinical Cancer Research"}],"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rep.bioscientifica.com\/view\/journals\/rep\/166\/1\/REP-22-0367.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rep.bioscientifica.com\/view\/journals\/rep\/166\/1\/REP-22-0367.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/166\/1\/37\/64065689\/rep-22-0367.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/166\/1\/37\/64065689\/rep-22-0367.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T17:10:26Z","timestamp":1767805826000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/166\/1\/37\/8217222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,9]]},"references-count":74,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,7,1]]}},"URL":"https:\/\/doi.org\/10.1530\/rep-22-0367","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,7,1]]},"published":{"date-parts":[[2023,6,9]]}}}