{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:16:59Z","timestamp":1791771419194,"version":"4.3.4"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>\u2003<\/jats:title>\n                  <jats:sec>\n                    <jats:title>In brief<\/jats:title>\n                    <jats:p>IFN-\u03bbs participate in the fetal\u2013maternal immune interaction, involving in immune regulation, uterine receptivity, cell migration and adhesion, and endometrium apoptosis. Our study helps to elucidate the underlying causes of the IFN-\u03bbs deficiency to spontaneous pregnancy loss in women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Immunotherapy has been commonly used to prevent recurrent pregnancy loss in women with inadequate uterus receptivity or immunological imbalance. Many immune regulators are now identified as having crucial roles at the embryo\u2013maternal interface. However, the clinical efficacy of immunity-related markers during the peri-implantation period remains to be explored in depth. Here, we demonstrated that endometrial expression of interferon-\u03bb (IFN-\u03bb), regarded as a newer class of interferons, is aberrantly lower in women who suffered from recurrent implantation failure than that in fertile control. We further uncovered genetic and biochemical evidence that IFN-\u03bb is induced directly by estrogen in the endometrial cells, and IFN-\u03bb pathway may play multiple roles involving the inflammatory response, uterine receptivity, cell migration, and blastocyst adhesion. Furthermore, we indicated IFN-\u03bb lessens the sensitivity of endometrium to FASL-mediated apoptosis. In addition to uncovering this IFN-\u03bb as a novel nonredundant regulator that participates in the fetal\u2013maternal immune interaction, our study helps to elucidate the underlying causes of spontaneous pregnancy loss in women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/rep-22-0463","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T09:51:00Z","timestamp":1679305860000},"page":"569-582","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":6,"title":["Interferon-\u03bb contributes to endometrial receptivity"],"prefix":"10.1093","volume":"165","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0240-9056","authenticated-orcid":false,"given":"Kezhen","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Reproductive Endocrinology , Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology , Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqun","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology , Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wu","sequence":"additional","affiliation":[{"name":"The Swedish University of Agricultural Sciences , Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,4,21]]},"reference":[{"key":"2026010712091371700_bib1","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1093\/glycob\/8.3.269","article-title":"Human endometrial MUC1 carries keratan sulfate: characteristic glycoforms in the luminal epithelium at receptivity","volume":"8","author":"Aplin","year":"1998","journal-title":"Glycobiology"},{"key":"2026010712091371700_bib2","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/j.chom.2016.03.008","article-title":"Type III interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection","volume":"19","author":"Bayer","year":"2016","journal-title":"Cell Host and Microbe"},{"key":"2026010712091371700_bib3","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.jri.2015.02.002","article-title":"The role of apoptosis in human embryo implantation","volume":"108","author":"Boeddeker","year":"2015","journal-title":"Journal of Reproductive Immunology"},{"key":"2026010712091371700_bib4","first-page":"45","article-title":"Placental apoptosis in preeclampsia, intrauterine growth retardation, and HELLP syndrome: an immunohistochemical study with caspase-3 and bcl-2","volume":"40","author":"Cali","year":"2013","journal-title":"Clinical and Experimental Obstetrics and Gynecology"},{"key":"2026010712091371700_bib5","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.4049\/jimmunol.145.3.1029","article-title":"Idiotype vaccination against murine B cell lymphoma. 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