{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:24:20Z","timestamp":1778862260044,"version":"3.51.4"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5,1]]},"abstract":"<jats:title>\u2003<\/jats:title>\n                  <jats:sec>\n                    <jats:title>In brief<\/jats:title>\n                    <jats:p>Hypoxia is vital for the establishment of the maternal\u2013fetal interface during early pregnancy. This study shows that decidual macrophages (dM\u03c6) could be recruited and reside in decidua under the regulation of hypoxia\/VEGFA-CCL2 axis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Infiltration and residence of decidual macrophages (dM\u03c6) are of great significance to pregnancy maintenance for their role in angiogenesis, placental development, and inducing immune tolerance. Besides, hypoxia has now been acknowledged as an important biological event at maternal\u2013fetal interface in the first trimester. However, whether and how hypoxia regulates biofunctions of dM\u03c6 remain elusive. Herein, we observed increased expression of C\u2013C motif chemokine ligand 2 (CCL2) and residence of macrophages in decidua compared to secretory-phase endometrium. Moreover, hypoxia treatment on stromal cells improved the migration and adhesion of dM\u03c6. Mechanistically, these effects might be mediated by upregulated CCL2 and adhesion molecules (especially ICAM2 and ICAM5) on stromal cells in the presence of endogenous vascular endothelial growth factor-A (VEGFA) in hypoxia. These findings were also verified by recombinant VEGFA and indirect coculture, indicating that the interaction between stromal cells and dM\u03c6 in hypoxia condition may facilitate dM\u03c6 recruitment and residence. In conclusion, VEGFA derived from a hypoxic environment may manipulate CCL2\/CCR2 and adhesion molecules to enhance the interactions between dM\u03c6 and stromal cells and thus contribute to the enrichment of macrophages in decidua early during normal pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/rep-22-0473","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T09:49:52Z","timestamp":1676972992000},"page":"543-555","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":12,"title":["Hypoxia-mediated chemotaxis and residence of macrophage in decidua by secreting VEGFA and CCL2 during normal pregnancy"],"prefix":"10.1093","volume":"165","author":[{"given":"Xue-Yun","family":"Qin","sequence":"first","affiliation":[{"name":"Laboratory for Reproductive Immunology , Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, People\u2019s Republic of China"},{"name":"NHC Key Lab of Reproduction Regulation , Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University, Shanghai, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Hui","family":"Shen","sequence":"additional","affiliation":[{"name":"Laboratory for Reproductive Immunology , Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, People\u2019s Republic of China"},{"name":"NHC Key Lab of Reproduction Regulation , Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University, Shanghai, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory for Reproductive Immunology , Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory for Reproductive Immunology , Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Xie","sequence":"additional","affiliation":[{"name":"Center for Diagnosis and Treatment of Cervical and Uterine Diseases , Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory for Reproductive Immunology , Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics , Hospital of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai, People\u2019s Republic of China"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases , Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Mei","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center , Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medicine School, Nanjing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9276-0722","authenticated-orcid":false,"given":"Ming-Qing","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory for Reproductive Immunology , Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, People\u2019s Republic of China"},{"name":"NHC Key Lab of Reproduction Regulation , Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University, Shanghai, People\u2019s Republic of China"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases , Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,3,29]]},"reference":[{"key":"2026021211242650800_bib1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02752","article-title":"The proinflammatory and proangiogenic macrophage migration inhibitory factor is a potential regulator in proliferative diabetic retinopathy","volume":"10","author":"Abu El-Asrar","year":"2019","journal-title":"Frontiers in Immunology"},{"key":"2026021211242650800_bib2","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1093\/humupd\/dms011","article-title":"The vascular endothelial growth factor family in adverse pregnancy outcomes","volume":"18","author":"Andraweera","year":"2012","journal-title":"Human Reproduction Update"},{"key":"2026021211242650800_bib3","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1096\/fj.14-267054","article-title":"The hypoxia-inducible miR-429 regulates hypoxia-inducible factor-1\u03b1 expression in human endothelial cells through a negative feedback loop","volume":"29","author":"Bartoszewska","year":"2015","journal-title":"FASEB Journal"},{"key":"2026021211242650800_bib4","doi-asserted-by":"publisher","first-page":"2160","DOI":"10.1093\/humrep\/dev156","article-title":"Vascular endothelial growth factor (VEGF) regulation by hypoxia inducible factor-1 alpha (HIF1A) starts and peaks during endometrial breakdown, not repair, in a mouse menstrual-like model","volume":"30","author":"Chen","year":"2015","journal-title":"Human Reproduction"},{"key":"2026021211242650800_bib5","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1172\/JCI20465","article-title":"VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment","volume":"113","author":"Cursiefen","year":"2004","journal-title":"Journal of Clinical Investigation"},{"key":"2026021211242650800_bib6","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02951","article-title":"Crosstalk Between Hypoxia and ER Stress Response: A Key Regulator of Macrophage Polarization","volume":"10","author":"D\u00edaz-Bulnes","year":"2019","journal-title":"Frontiers in Immunology"},{"key":"2026021211242650800_bib7","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1146\/annurev-immunol-032712-100003","article-title":"Immunology of the maternal-fetal interface","volume":"31","author":"Erlebacher","year":"2013","journal-title":"Annual Review of Immunology"},{"key":"2026021211242650800_bib8","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.3390\/cancers12071882","article-title":"CCR2 of Tumor Microenvironmental Cells Is a Relevant Modulator of Glioma Biology","volume":"12","author":"Felsenstein","year":"2020","journal-title":"Cancers (Basel)"},{"key":"2026021211242650800_bib9","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06182-5","article-title":"Lin(-)CCR2(+) hematopoietic stem and progenitor cells overcome resistance to PD-1 blockade","volume":"9","author":"Flores","year":"2018","journal-title":"Nature Communications"},{"key":"2026021211242650800_bib10","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.3892\/or.2016.4956","article-title":"Breast cancer-associated high-order SNP-SNP interaction of CXCL12\/CXCR4-related genes by an improved multifactor dimensionality reduction (MDR-ER)","volume":"36","author":"Fu","year":"2016","journal-title":"Oncology Reports"},{"key":"2026021211242650800_bib11","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1172\/JCI118447","article-title":"Hypoxia alters early gestation human cytotrophoblast differentiation\/invasion in vitro and models the placental defects that occur in preeclampsia","volume":"97","author":"Genbacev","year":"1996","journal-title":"Journal of Clinical Investigation"},{"key":"2026021211242650800_bib12","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-020-00589-8","article-title":"CCL2\/CCR2 signaling in cancer pathogenesis","volume":"18","author":"Hao","year":"2020","journal-title":"Cell Communication and Signaling"},{"key":"2026021211242650800_bib13","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.1093\/humrep\/dem208","article-title":"Regulation of C-C motif chemokine ligand 2 and its receptor in human decidual stromal cells by pregnancy-associated hormones in early gestation","volume":"22","author":"He","year":"2007","journal-title":"Human Reproduction"},{"key":"2026021211242650800_bib14","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1093\/molehr\/gat094","article-title":"IL-33 enhances proliferation and invasiveness of decidual stromal cells by up-regulation of CCL2\/CCR2 via NF-\u03baB and ERK1\/2 signaling","volume":"20","author":"Hu","year":"2014","journal-title":"Molecular Human Reproduction"},{"key":"2026021211242650800_bib15","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1093\/humupd\/dmi043","article-title":"The regulation of trophoblast differentiation by oxygen in the first trimester of pregnancy","volume":"12","author":"James","year":"2006","journal-title":"Human Reproduction Update"},{"key":"2026021211242650800_bib16","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26870-y","article-title":"Ccl2 deficiency protects against chronic renal injury in murine renovascular hypertension","volume":"8","author":"Kashyap","year":"2018","journal-title":"Scientific Reports"},{"key":"2026021211242650800_bib17","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/s41590-018-0113-3","article-title":"Regulation of macrophage immunometabolism in atherosclerosis","volume":"19","author":"Koelwyn","year":"2018","journal-title":"Nature Immunology"},{"key":"2026021211242650800_bib18","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1189\/jlb.1A0815-351R","article-title":"Decidual macrophages: key regulators of vascular remodeling in human pregnancy","volume":"100","author":"Lash","year":"2016","journal-title":"Journal of Leukocyte Biology"},{"key":"2026021211242650800_bib19","doi-asserted-by":"publisher","first-page":"2502","DOI":"10.1210\/jc.2011-0055","article-title":"NF\u03baB and JNK\/MAPK activation mediates the production of major macrophage- or dendritic cell-recruiting chemokine in human first trimester decidual cells in response to proinflammatory stimuli","volume":"96","author":"Li","year":"2011","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2026021211242650800_bib20","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.devcel.2013.01.009","article-title":"Peripheral nerve-derived CXCL12 and VEGF-A regulate the patterning of arterial vessel branching in developing limb skin","volume":"24","author":"Li","year":"2013","journal-title":"Developmental Cell"},{"key":"2026021211242650800_bib21","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01003","article-title":"Hypoxia enhances endothelial intercellular adhesion molecule 1 protein level through upregulation of arginase Type II and mitochondrial oxidative stress","volume":"10","author":"Liang","year":"2019","journal-title":"Frontiers in Physiology"},{"key":"2026021211242650800_bib22","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02481-5","article-title":"Macrophages orchestrate breast cancer early dissemination and metastasis","volume":"9","author":"Linde","year":"2018","journal-title":"Nature Communications"},{"key":"2026021211242650800_bib23","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/path.3989","article-title":"Vascular endothelial growth factor-induced skin carcinogenesis depends on recruitment and alternative activation of macrophages","volume":"227","author":"Linde","year":"2012","journal-title":"Journal of Pathology"},{"key":"2026021211242650800_bib24","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1530\/REP-18-0112","article-title":"Indoleamine 2,3-dioxygenase suppresses the cytotoxicity of 1 NK cells in response to ectopic endometrial stromal cells in endometriosis","volume":"156","author":"Liu","year":"2018","journal-title":"Reproduction"},{"key":"2026021211242650800_bib25","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1080\/15548627.2020.1833515","article-title":"Rapamycin prevents spontaneous abortion by triggering decidual stromal cell autophagy-mediated NK cell residence","volume":"17","author":"Lu","year":"2021","journal-title":"Autophagy"},{"key":"2026021211242650800_bib26","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1084\/jem.20132130","article-title":"Chemokine-coupled \u03b22 integrin-induced macrophage Rac2-myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis","volume":"211","author":"Morrison","year":"2014","journal-title":"Journal of Experimental Medicine"},{"key":"2026021211242650800_bib27","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1111\/aji.12477","article-title":"The role of decidual macrophages during normal and pathological pregnancy","volume":"75","author":"Ning","year":"2016","journal-title":"American Journal of Reproductive Immunology"},{"key":"2026021211242650800_bib28","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1093\/humupd\/dmp046","article-title":"Beyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy","volume":"16","author":"Pringle","year":"2010","journal-title":"Human Reproduction Update"},{"key":"2026021211242650800_bib29","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1182\/blood-2011-01-332890","article-title":"Hypoxic induction of vascular endothelial growth factor regulates murine hematopoietic stem cell function in the low-oxygenic niche","volume":"118","author":"Rehn","year":"2011","journal-title":"Blood"},{"key":"2026021211242650800_bib30","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.3389\/fimmu.2018.01930","article-title":"Chemokine-induced macrophage polarization in inflammatory conditions","volume":"9","author":"Ruytinx","year":"2018","journal-title":"Frontiers in Immunology"},{"key":"2026021211242650800_bib31","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1111\/jog.14192","article-title":"Association of vascular endothelial growth factor A polymorphisms and aberrant expression of connexin 43 and VEGFA with idiopathic recurrent spontaneous miscarriage","volume":"46","author":"Sajjadi","year":"2020","journal-title":"Journal of Obstetrics and Gynaecology Research"},{"key":"2026021211242650800_bib32","doi-asserted-by":"publisher","first-page":"8769","DOI":"10.1038\/s41598-021-88000-5","article-title":"Vegfa promoter gene hypermethylation at HIF1\u03b1 binding site is an early contributor to CKD progression after renal ischemia","volume":"11","author":"S\u00e1nchez-Navarro","year":"2021","journal-title":"Scientific Reports"},{"key":"2026021211242650800_bib33","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/nrc1187","article-title":"Targeting HIF-1 for cancer therapy","volume":"3","author":"Semenza","year":"2003","journal-title":"Nature Reviews. Cancer"},{"key":"2026021211242650800_bib34","doi-asserted-by":"publisher","first-page":"3664","DOI":"10.1172\/JCI67230","article-title":"HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations","volume":"123","author":"Semenza","year":"2013","journal-title":"Journal of Clinical Investigation"},{"key":"2026021211242650800_bib35","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1530\/REP-21-0314","article-title":"HIF1A-induced heme oxygenase 1 promotes the survival of decidual stromal cells against excess heme-mediated oxidative stress","volume":"163","author":"Shen","year":"2021","journal-title":"Reproduction"},{"key":"2026021211242650800_bib36","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1007\/s10815-014-0223-2","article-title":"Gene-gene interactions and gene polymorphisms of VEGFA and EG-VEGF gene systems in recurrent pregnancy loss","volume":"31","author":"Su","year":"2014","journal-title":"Journal of Assisted Reproduction and Genetics"},{"key":"2026021211242650800_bib37","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13480","article-title":"Immune status of decidual macrophages is dependent on the CCL2\/CCR2\/JAK2 pathway during early pregnancy","volume":"86","author":"Wei","year":"2021","journal-title":"American Journal of Reproductive Immunology"},{"key":"2026021211242650800_bib38","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04505-5","article-title":"Long non-coding RNA PAARH promotes hepatocellular carcinoma progression and angiogenesis via upregulating HOTTIP and activating HIF-1\u03b1\/VEGF signaling","volume":"13","author":"Wei","year":"2022","journal-title":"Cell Death and Disease"},{"key":"2026021211242650800_bib39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191040","article-title":"VEGF may contribute to macrophage recruitment and M2 polarization in the decidua","volume":"13","author":"Wheeler","year":"2018","journal-title":"PLoS One"},{"key":"2026021211242650800_bib40","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1182\/blood-2012-01-403386","article-title":"CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair","volume":"120","author":"Willenborg","year":"2012","journal-title":"Blood"},{"key":"2026021211242650800_bib41","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-47831-z","article-title":"MMP12 inhibits corneal neovascularization and inflammation through regulation of CCL2","volume":"9","author":"Wolf","year":"2019","journal-title":"Scientific Reports"},{"key":"2026021211242650800_bib42","doi-asserted-by":"publisher","first-page":"3579","DOI":"10.3390\/jcm10163579","article-title":"Evaluating markers of immune tolerance and angiogenesis in maternal blood for an association with risk of pregnancy loss","volume":"10","author":"Wyatt","year":"2021","journal-title":"Journal of Clinical Medicine"},{"key":"2026021211242650800_bib43","doi-asserted-by":"publisher","first-page":"2825","DOI":"10.1002\/ijc.29655","article-title":"CXCL12-CXCR7 axis is important for tumor endothelial cell angiogenic property","volume":"137","author":"Yamada","year":"2015","journal-title":"International Journal of Cancer"},{"key":"2026021211242650800_bib44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076605","article-title":"Autophagy induced by HIF1\u03b1 overexpression supports trophoblast invasion by supplying cellular energy","volume":"8","author":"Yamanaka-Tatematsu","year":"2013","journal-title":"PLoS One"},{"key":"2026021211242650800_bib45","doi-asserted-by":"publisher","first-page":"2459","DOI":"10.1080\/15548627.2022.2039000","article-title":"A defective lysophosphatidic acid-autophagy axis increases miscarriage risk by restricting decidual macrophage residence","volume":"18","author":"Yang","year":"2022","journal-title":"Autophagy"},{"key":"2026021211242650800_bib46","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13110","article-title":"Decidual stromal cells promote the differentiation of CD56(bright) CD16(-) NK cells by secreting IL-24 in early pregnancy","volume":"81","author":"Yang","year":"2019","journal-title":"American Journal of Reproductive Immunology"},{"key":"2026021211242650800_bib47","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00978","article-title":"Targeting VEGF\/VEGFR to modulate antitumor immunity","volume":"9","author":"Yang","year":"2018","journal-title":"Frontiers in Immunology"},{"key":"2026021211242650800_bib48","doi-asserted-by":"publisher","first-page":"3502","DOI":"10.1080\/15384101.2019.1689481","article-title":"HIF-1\u03b1 regulates angiogenesis via Notch1\/STAT3\/ETBR pathway in trophoblastic cells","volume":"18","author":"Yu","year":"2019","journal-title":"Cell Cycle"},{"key":"2026021211242650800_bib49","doi-asserted-by":"publisher","first-page":"9675","DOI":"10.3390\/ijms22189675","article-title":"The impact of hypoxia in early pregnancy on placental cells","volume":"22","author":"Zhao","year":"2021","journal-title":"International Journal of Molecular Sciences"},{"key":"2026021211242650800_bib50","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abj2488","article-title":"Fructose-1,6-bisphosphate prevents pregnancy loss by inducing decidual COX-2(+) macrophage differentiation","volume":"8","author":"Zhou","year":"2022","journal-title":"Science Advances"}],"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rep.bioscientifica.com\/view\/journals\/rep\/165\/5\/REP-22-0473.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rep.bioscientifica.com\/view\/journals\/rep\/165\/5\/REP-22-0473.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/165\/5\/543\/63880443\/rep-22-0473.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/165\/5\/543\/63880443\/rep-22-0473.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T16:24:36Z","timestamp":1770913476000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/165\/5\/543\/8217211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,29]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5,1]]}},"URL":"https:\/\/doi.org\/10.1530\/rep-22-0473","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,5,1]]},"published":{"date-parts":[[2023,3,29]]}}}