{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:23:18Z","timestamp":1777605798690,"version":"3.51.4"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:title>\u2003<\/jats:title>\n                  <jats:sec>\n                    <jats:title>In brief<\/jats:title>\n                    <jats:p>Mrhl lncRNA regulates the Wnt signaling pathway in mouse spermatogonial cells, resulting in the commitment of B-type spermatogonia to meiotic entry through Mrhl lncRNA-mediated regulation of Sox8. Mrhl lncRNA regulates chromatin dynamics of the Sox8 promoter\/enhancer interaction through chromatin looping.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Proliferation and meiotic division of spermatogonial stem cells are highly regulated biological processes that occur during spermatogenesis. In addition to protein-coding genes, the mammalian genome encodes thousands of lncRNAs which are spatio-temporally expressed and play key role(s) in cellular differentiation and development. Mrhl lncRNA is one such mono-exonic polyadenylated non-coding RNA encoded within the 15th intron of the mouse Phkb gene. Mrhl lncRNA is expressed in mouse testis amongst other tissues. The RNA is nuclear localized and predominantly bound to chromatin in GC-1 spg cells (derived from B-type spermatogonia). It regulates multiple genes belonging to different biological processes including Wnt signaling. Wnt activation of GC-1 spg cells downregulates Mrhl lncRNA expression, in turn activating the expression of meiotic marker genes and downregulating stem cell markers. We have mapped the genomic loci bound by Mrhl lncRNA and identified 37 genes to be regulated by its physical association. Sox8 gene, one among these, is regulated through its interaction at its promoter through RNA:DNA:DNA triplex structure and chromatin looping mediated by the architectural proteins CTCF and YY1. Here, we summarize our major findings on this novel lncRNA starting from its discovery to biological function(s), particularly during meiotic commitment\/initiation in mouse spermatogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/rep-23-0065","type":"journal-article","created":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T17:04:05Z","timestamp":1687453445000},"page":"R39-R50","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":12,"title":["Molecular functions of\n                    <i>Mrhl<\/i>\n                    lncRNA in mouse spermatogenesis"],"prefix":"10.1093","volume":"166","author":[{"given":"Bhavana","family":"Kayyar","sequence":"first","affiliation":[{"name":"Molecular Biology and Genetics Unit , JNCASR, Jakkur, Bangalore, India"},{"name":"Touchlight Genetics Ltd. Hampton , London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shubhangini","family":"Kataruka","sequence":"additional","affiliation":[{"name":"Molecular Biology and Genetics Unit , JNCASR, Jakkur, Bangalore, India"},{"name":"Department of Genetics , Yale School of Medicine, New Haven, Connecticut, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay","family":"Suresh Akhade","sequence":"additional","affiliation":[{"name":"Molecular Biology and Genetics Unit , JNCASR, Jakkur, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0201-9437","authenticated-orcid":false,"given":"M R S","family":"Rao","sequence":"additional","affiliation":[{"name":"Molecular Biology and Genetics Unit , JNCASR, Jakkur, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,7,31]]},"reference":[{"key":"2026010712092698200_bib1","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1080\/15476286.2014.996070","article-title":"Genome wide chromatin occupancy of Mrhl RNA and its role in gene regulation in mouse spermatogonial cells","volume":"11","author":"Akhade","year":"2014","journal-title":"RNA Biology"},{"key":"2026010712092698200_bib2","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1093\/nar\/gkv1023","article-title":"Mechanism of Wnt signaling induced downregulation of Mrhl long non-coding RNA in mouse spermatogonial cells","volume":"44","author":"Akhade","year":"2016","journal-title":"Nucleic Acids Research"},{"key":"2026010712092698200_bib3","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/978-981-10-5203-3_1","article-title":"Long noncoding RNA: genome organization and mechanism of action","volume":"1008","author":"Akhade","year":"2017","journal-title":"Long Non Coding RNA Biology. Advances in Experimental Medicine and Biology"},{"key":"2026010712092698200_bib4","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.60583","article-title":"Beyond the RNA-dependent function of LncRNA genes","volume":"9","author":"Ali","year":"2020","journal-title":"eLife"},{"key":"2026010712092698200_bib5","doi-asserted-by":"publisher","first-page":"14976","DOI":"10.1073\/pnas.0807297105","article-title":"Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice","volume":"105","author":"Anderson","year":"2008","journal-title":"PNAS"},{"key":"2026010712092698200_bib6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002248","article-title":"Tsx produces a long noncoding RNA and has general functions in the germline, stem cells, and brain","volume":"7","author":"Anguera","year":"2011","journal-title":"PLOS Genetics"},{"key":"2026010712092698200_bib7","doi-asserted-by":"publisher","first-page":"3140","DOI":"10.1128\/MCB.00006-12","article-title":"Mrhl RNA, a long noncoding RNA, negatively regulates Wnt signaling through its protein partner Ddx5\/p68 in mouse spermatogonial cells","volume":"32","author":"Arun","year":"2012","journal-title":"Molecular and Cellular Biology"},{"key":"2026010712092698200_bib8","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.15635","article-title":"Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration","volume":"5","author":"Barrionuevo","year":"2016","journal-title":"eLife"},{"key":"2026010712092698200_bib9","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1128\/mcb.10.1.28-36.1990","article-title":"The product of the H19 gene may function as an RNA","volume":"10","author":"Brannan","year":"1990","journal-title":"Molecular and Cellular Biology"},{"key":"2026010712092698200_bib10","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/0092-8674(9290519-i","article-title":"The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus","volume":"71","author":"Brockdorff","year":"1992","journal-title":"Cell"},{"key":"2026010712092698200_bib11","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1242\/dev.01087","article-title":"Functional analysis of Sox8 and Sox9 during sex determination in the mouse","volume":"131","author":"Chaboissier","year":"2004","journal-title":"Development"},{"key":"2026010712092698200_bib12","doi-asserted-by":"publisher","DOI":"10.1093\/narcan\/zcab042","article-title":"LncRNA HMrhl regulates expression of cancer related genes in chronic myelogenous leukemia through chromatin association","volume":"3","author":"Choudhury","year":"2021","journal-title":"NAR Cancer"},{"key":"2026010712092698200_bib13","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1101\/gr.132159.111","article-title":"The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression","volume":"22","author":"Derrien","year":"2012","journal-title":"Genome Research"},{"key":"2026010712092698200_bib14","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nature11233","article-title":"Landscape of transcription in human cells","volume":"489","author":"Djebali","year":"2012","journal-title":"Nature"},{"key":"2026010712092698200_bib15","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","author":"ENCODE Project Consortium","year":"2012","journal-title":"Nature"},{"key":"2026010712092698200_bib16","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.ncrna.2019.08.001","article-title":"A novel enhancer RNA, HMrhl, positively regulates its host gene, phkb, in chronic myelogenous leukemia","volume":"4","author":"Fatima","year":"2019","journal-title":"Non-Coding RNA Research"},{"key":"2026010712092698200_bib17","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.mce.2013.09.026","article-title":"Control of mammalian germ cell entry into meiosis","volume":"382","author":"Feng","year":"2014","journal-title":"Molecular and Cellular Endocrinology"},{"key":"2026010712092698200_bib18","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1261\/rna.838308","article-title":"A novel noncoding RNA processed by Drosha is restricted to nucleus in mouse","volume":"14","author":"Ganesan","year":"2008","journal-title":"RNA"},{"key":"2026010712092698200_bib19","doi-asserted-by":"publisher","first-page":"549","DOI":"10.4103\/aja202156","article-title":"The role of retinoic acid in the commitment to meiosis","volume":"23","author":"Gewiss","year":"2021","journal-title":"Asian Journal of Andrology"},{"key":"2026010712092698200_bib20","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1002\/mrd.23448","article-title":"STRA8 induces transcriptional changes in germ cells during spermatogonial development","volume":"88","author":"Gewiss","year":"2021","journal-title":"Molecular Reproduction and Development"},{"key":"2026010712092698200_bib21","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1530\/REP-08-0510","article-title":"Wnt signaling promotes proliferation and stemness regulation of spermatogonial stem\/progenitor cells","volume":"138","author":"Golestaneh","year":"2009","journal-title":"Reproduction"},{"key":"2026010712092698200_bib22","doi-asserted-by":"publisher","first-page":"37888","DOI":"10.1074\/jbc.M608147200","article-title":"Post-meiotic shifts in HSPA2\/HSP702 chaperone activity during mouse spermatogenesis","volume":"281","author":"Govin","year":"2006","journal-title":"Journal of Biological Chemistry"},{"key":"2026010712092698200_bib23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1152\/physrev.00013.2015","article-title":"Spermatogenesis: the commitment to meiosis","volume":"96","author":"Griswold","year":"2016","journal-title":"Physiological Reviews"},{"key":"2026010712092698200_bib24","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/nature07672","article-title":"Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals","volume":"458","author":"Guttman","year":"2009","journal-title":"Nature"},{"key":"2026010712092698200_bib25","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1016\/j.molcel.2022.05.027","article-title":"Integrated lncRNA function upon genomic and epigenomic regulation","volume":"82","author":"Herman","year":"2022","journal-title":"Molecular Cell"},{"key":"2026010712092698200_bib26","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/nrg3863","article-title":"RNA-mediated epigenetic regulation of gene expression","volume":"16","author":"Holoch","year":"2015","journal-title":"Nature Reviews. Genetics"},{"key":"2026010712092698200_bib28","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1007\/s13258-018-0690-4","article-title":"LncRNA Gm2044 highly expresses in spermatocyte and inhibits Utf1 translation by interacting with Utf1 mRNA","volume":"40","author":"Hu","year":"2018","journal-title":"Genes and Genomics"},{"key":"2026010712092698200_bib27","doi-asserted-by":"publisher","first-page":"462","DOI":"10.20892\/j.issn.2095-3941.2019.0062","article-title":"Sex-determining region Y box-containing genes: regulators and biomarkers in gynecological cancers","volume":"16","author":"Hu","year":"2019","journal-title":"Cancer Biology and Medicine"},{"key":"2026010712092698200_bib29","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.devcel.2020.01.010","article-title":"MEIOSIN directs the switch from mitosis to meiosis in mammalian germ cells","volume":"52","author":"Ishiguro","year":"2020","journal-title":"Developmental Cell"},{"key":"2026010712092698200_bib30","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/s41588-022-01014-1","article-title":"Transcriptional kinetics and molecular functions of long noncoding RNAs","volume":"54","author":"Johnsson","year":"2022","journal-title":"Nature Genetics"},{"key":"2026010712092698200_bib31","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-020-00660-6","article-title":"Long non-coding RNAs (lncRNAs) in spermatogenesis and male infertility","volume":"18","author":"Joshi","year":"2020","journal-title":"Reproductive Biology and Endocrinology"},{"key":"2026010712092698200_bib32","doi-asserted-by":"publisher","first-page":"4129","DOI":"10.1242\/dev.091793","article-title":"Sox proteins: regulators of cell fate specification and differentiation","volume":"140","author":"Kamachi","year":"2013","journal-title":"Development"},{"key":"2026010712092698200_bib33","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.molcel.2013.11.012","article-title":"Interactions between JARID2 and noncoding RNAs regulate PRC2 recruitment to chromatin","volume":"53","author":"Kaneko","year":"2014","journal-title":"Molecular Cell"},{"key":"2026010712092698200_bib34","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00632-16","article-title":"Mrhl long noncoding RNA mediates meiotic commitment of mouse spermatogonial cells by regulating Sox8 expression","volume":"37","author":"Kataruka","year":"2017","journal-title":"Molecular and Cellular Biology"},{"key":"2026010712092698200_bib35","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.00475-21","article-title":"Regulation of Sox8 through lncRNA Mrhl-mediated chromatin looping in mouse spermatogonia","volume":"42","author":"Kayyar","year":"2022","journal-title":"Molecular and Cellular Biology"},{"key":"2026010712092698200_bib36","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1093\/biolre\/ioy077","article-title":"Spermatogonial stem cells","volume":"99","author":"Kubota","year":"2018","journal-title":"Biology of Reproduction"},{"key":"2026010712092698200_bib37","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/bs.ctdb.2019.01.007","article-title":"Roles and regulation of SOX transcription factors in skeletogenesis","volume":"133","author":"Lefebvre","year":"2019","journal-title":"Current Topics in Developmental Biology"},{"key":"2026010712092698200_bib38","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1101\/gr.264333.120","article-title":"Panoramic transcriptome analysis and functional screening of long noncoding RNAs in mouse spermatogenesis","volume":"31","author":"Li","year":"2021","journal-title":"Genome Research"},{"key":"2026010712092698200_bib39","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/3855","article-title":"Cyclin A1 is required for meiosis in the male mouse","volume":"20","author":"Liu","year":"1998","journal-title":"Nature Genetics"},{"key":"2026010712092698200_bib40","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1146\/annurev.cellbio.20.010403.113126","article-title":"The Wnt signaling pathway in development and disease","volume":"20","author":"Logan","year":"2004","journal-title":"Annual Review of Cell and Developmental Biology"},{"key":"2026010712092698200_bib41","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1348-2","article-title":"The multidimensional mechanisms of long noncoding RNA function","volume":"18","author":"Marchese","year":"2017","journal-title":"Genome Biology"},{"key":"2026010712092698200_bib42","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/s41580-022-00566-8","article-title":"Long non-coding RNAs: definitions, functions, challenges and recommendations","volume":"24","author":"Mattick","year":"2023","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"2026010712092698200_bib43","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/nrg2521","article-title":"Long non-coding RNAs: insights into functions","volume":"10","author":"Mercer","year":"2009","journal-title":"Nature Reviews. Genetics"},{"key":"2026010712092698200_bib44","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8743","article-title":"MEG3 long noncoding RNA regulates the TGF-beta pathway genes through formation of RNA-DNA triplex structures","volume":"6","author":"Mondal","year":"2015","journal-title":"Nature Communications"},{"key":"2026010712092698200_bib45","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/bies.20349","article-title":"Molecular features of meiotic recombination hot spots","volume":"28","author":"Nishant","year":"2006","journal-title":"BioEssays"},{"key":"2026010712092698200_bib46","doi-asserted-by":"publisher","first-page":"5620","DOI":"10.1128\/MCB.24.12.5620-5634.2004","article-title":"Characterization of a mouse recombination hot spot locus encoding a novel non-protein-coding RNA","volume":"24","author":"Nishant","year":"2004","journal-title":"Molecular and Cellular Biology"},{"key":"2026010712092698200_bib47","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/sj.cr.7290260","article-title":"Wnt signaling in disease and in development","volume":"15","author":"Nusse","year":"2005","journal-title":"Cell Research"},{"key":"2026010712092698200_bib48","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.ydbio.2008.01.042","article-title":"Sox8 is a critical regulator of adult Sertoli cell function and male fertility","volume":"316","author":"O'Bryan","year":"2008","journal-title":"Developmental Biology"},{"key":"2026010712092698200_bib49","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/nature01266","article-title":"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs","volume":"420","author":"Okazaki","year":"2002","journal-title":"Nature"},{"key":"2026010712092698200_bib50","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.celrep.2015.03.043","article-title":"PARTICLE, a triplex-forming long ncRNA, regulates locus-specific methylation in response to low-dose irradiation","volume":"11","author":"O'Leary","year":"2015","journal-title":"Cell Reports"},{"key":"2026010712092698200_bib51","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1038\/nrg3663","article-title":"CTCF: an architectural protein bridging genome topology and function","volume":"15","author":"Ong","year":"2014","journal-title":"Nature Reviews. Genetics"},{"key":"2026010712092698200_bib52","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1083\/jcb.135.2.469","article-title":"Characterization of a premeiotic germ cell-specific cytoplasmic protein encoded by Stra8, a novel retinoic acid-responsive gene","volume":"135","author":"Oulad-Abdelghani","year":"1996","journal-title":"Journal of Cell Biology"},{"key":"2026010712092698200_bib54","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2021.102250","article-title":"LncRNA Mrhl orchestrates differentiation programs in mouse embryonic stem cells through chromatin mediated regulation","volume":"53","author":"Pal","year":"2021","journal-title":"Stem Cell Research"},{"key":"2026010712092698200_bib53","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.00036-22","article-title":"Identification of PAX6 and NFAT4 as the transcriptional regulators of the long noncoding RNA Mrhl in neuronal progenitors","volume":"42","author":"Pal","year":"2022","journal-title":"Molecular and Cellular Biology"},{"key":"2026010712092698200_bib55","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.cell.2009.06.001","article-title":"CTCF: master weaver of the genome","volume":"137","author":"Phillips","year":"2009","journal-title":"Cell"},{"key":"2026010712092698200_bib56","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/s1097-2765(0080069-6","article-title":"Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmc1, a germline-specific RecA homolog","volume":"1","author":"Pittman","year":"1998","journal-title":"Molecular Cell"},{"key":"2026010712092698200_bib57","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.molcel.2015.10.001","article-title":"LncRNA Khps1 regulates expression of the proto-oncogene SPHK1 via triplex-mediated changes in chromatin structure","volume":"60","author":"Postepska-Igielska","year":"2015","journal-title":"Molecular Cell"},{"key":"2026010712092698200_bib58","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1007\/BF00337387","article-title":"Identification and sequence characterization of a 13 kb EcoRI repeat fragment that harbors a DNA repair site of rat pachytene spermatocytes","volume":"103","author":"Ramachandra","year":"1994","journal-title":"Chromosoma"},{"key":"2026010712092698200_bib59","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.53972","article-title":"Sox8 and Sox9 act redundantly for ovarian-to-testicular fate reprogramming in the absence of R-spondin1 in mouse sex reversals","volume":"9","author":"Richardson","year":"2020","journal-title":"eLife"},{"key":"2026010712092698200_bib60","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1146\/annurev-biochem-051410-092902","article-title":"Genome regulation by long noncoding RNAs","volume":"81","author":"Rinn","year":"2012","journal-title":"Annual Review of Biochemistry"},{"key":"2026010712092698200_bib61","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1242\/dev.113.3.815","article-title":"Specific expression of a retinoic acid-regulated, zinc-finger gene, Rex-1, in preimplantation embryos, trophoblast and spermatocytes","volume":"113","author":"Rogers","year":"1991","journal-title":"Development"},{"key":"2026010712092698200_bib62","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.modgep.2007.10.007","article-title":"Transcriptome analysis of differentiating spermatogonia stimulated with kit ligand","volume":"8","author":"Rossi","year":"2008","journal-title":"Gene Expression Patterns"},{"key":"2026010712092698200_bib63","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1101\/gad.236869.113","article-title":"CTCF regulates the human p53 gene through direct interaction with its natural antisense transcript, Wrap53","volume":"28","author":"Saldana-Meyer","year":"2014","journal-title":"Genes and Development"},{"key":"2026010712092698200_bib64","doi-asserted-by":"publisher","first-page":"28101","DOI":"10.1074\/jbc.M304067200","article-title":"SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro","volume":"278","author":"Schepers","year":"2003","journal-title":"Journal of Biological Chemistry"},{"key":"2026010712092698200_bib65","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.606889","article-title":"Sorting sox: diverse roles for sox transcription factors during neural crest and craniofacial development","volume":"11","author":"Schock","year":"2020","journal-title":"Frontiers in Physiology"},{"key":"2026010712092698200_bib66","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/s41580-020-00315-9","article-title":"Gene regulation by long non-coding RNAs and its biological functions","volume":"22","author":"Statello","year":"2021","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"2026010712092698200_bib67","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/nsmb0207-103","article-title":"Transcriptional noise and the fidelity of initiation by RNA polymerase II","volume":"14","author":"Struhl","year":"2007","journal-title":"Nature Structural and Molecular Biology"},{"key":"2026010712092698200_bib68","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1006\/geno.1999.5756","article-title":"A novel testis-specific metallothionein-like protein, tesmin, is an early marker of male germ cell differentiation","volume":"57","author":"Sugihara","year":"1999","journal-title":"Genomics"},{"key":"2026010712092698200_bib69","doi-asserted-by":"publisher","first-page":"3894","DOI":"10.1128\/MCB.00322-08","article-title":"CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes","volume":"28","author":"Thompson","year":"2008","journal-title":"Molecular and Cellular Biology"},{"key":"2026010712092698200_bib70","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1080\/15476286.2019.1700332","article-title":"Revealing stage-specific expression patterns of long noncoding RNAs along mouse spermatogenesis","volume":"17","author":"Trovero","year":"2020","journal-title":"RNA Biology"},{"key":"2026010712092698200_bib71","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.cell.2013.06.020","article-title":"lincRNAs: genomics, evolution, and mechanisms","volume":"154","author":"Ulitsky","year":"2013","journal-title":"Cell"},{"key":"2026010712092698200_bib72","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1093\/nar\/gkg346","article-title":"HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2\/Conductin in human embryonic kidney cells","volume":"31","author":"Valenta","year":"2003","journal-title":"Nucleic Acids Research"},{"key":"2026010712092698200_bib73","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1016\/j.molcel.2011.08.018","article-title":"Molecular mechanisms of long noncoding RNAs","volume":"43","author":"Wang","year":"2011","journal-title":"Molecular Cell"},{"key":"2026010712092698200_bib74","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.bbrc.2010.08.130","article-title":"A novel ncRNA gene from mouse chromosome 5 trans-splices with Dmrt1 on chromosome 19","volume":"400","author":"Zhang","year":"2010","journal-title":"Biochemical and Biophysical Research Communications"}],"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rep.bioscientifica.com\/view\/journals\/rep\/166\/3\/REP-23-0065.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rep.bioscientifica.com\/downloadpdf\/journals\/rep\/166\/3\/REP-23-0065.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/166\/3\/R39\/64065297\/rep-23-0065.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/166\/3\/R39\/64065297\/rep-23-0065.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T17:09:34Z","timestamp":1767805774000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/166\/3\/R39\/8217159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,31]]},"references-count":74,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9,1]]}},"URL":"https:\/\/doi.org\/10.1530\/rep-23-0065","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,9,1]]},"published":{"date-parts":[[2023,7,31]]}}}