{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:05:23Z","timestamp":1788455123692,"version":"build-2803163510"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>\u2003<\/jats:title>\n                  <jats:sec>\n                    <jats:title>In brief<\/jats:title>\n                    <jats:p>Mitochondrial uncoupling proteins (UCPs) regulate mitochondrial activity and reactive oxygen species production through the transport of protons and metabolites. This study identified the expression of UCPs in human Sertoli cells, which proved to be modulators of their mitochondrial activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Mitochondrial uncoupling proteins (UCPs) are mitochondrial channels responsible for the transport of protons and small molecular substrates across the inner mitochondrial membrane. Altered UCP expression or function is commonly associated with mitochondrial dysfunction and increased oxidative stress, which are both known causes of male infertility. However, UCP expression and function in the human testis remain to be characterized. This study aimed to assess the UCP homologs (UCP1-6) expression and function in primary cultures of human Sertoli cells (hSCs). We identified the mRNA expression of all UCP homologs (UCP1-6) and protein expression of UCP1, UCP2, and UCP3 in hSCs. UCP inhibition by genipin for 24 h decreased hSCs proliferation without causing cytotoxicity (n\u2009=\u20096). Surprisingly, the prolonged UCP inhibition for 24 h decreased mitochondrial membrane potential, oxygen consumption rate (OCR), and endogenous reactive oxygen species (ROS) production. The metabolism of hSCs was also affected as UCP inhibition shifted their metabolism toward an increased pyruvate consumption. Taken together, these findings demonstrate that UCPs play a role as regulators of the mitochondrial function in hSCs, emphasizing their potential as targets in the study of male (in)fertility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/rep-23-0229","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T14:26:32Z","timestamp":1701267992000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":3,"title":["Mitochondrial uncoupling proteins regulate the metabolic function of human Sertoli cells"],"prefix":"10.1093","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0546-3480","authenticated-orcid":false,"given":"David F","family":"Carrageta","sequence":"first","affiliation":[{"name":"Clinical and Experimental Endocrinology , UMIB - Unit for Multidisciplinary Research in Biomedicine, ICBAS - School of Medicine and Biomedical Sciences, University of Porto, Rua Jorge de Viterbo Ferreira 228, Porto, Portugal"},{"name":"Laboratory for Integrative and Translational Research in Population Health (ITR) , University of Porto, Rua das Taipas 136, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1423-5869","authenticated-orcid":false,"given":"La\u00eds","family":"Freire-Brito","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Endocrinology , UMIB - Unit for Multidisciplinary Research in Biomedicine, ICBAS - School of Medicine and Biomedical Sciences, University of Porto, Rua Jorge de Viterbo Ferreira 228, Porto, Portugal"},{"name":"Laboratory for Integrative and Translational Research in Population Health (ITR) , University of Porto, Rua das Taipas 136, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3276-5094","authenticated-orcid":false,"given":"B\u00e1rbara","family":"Guerra-Carvalho","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Endocrinology , UMIB - Unit for Multidisciplinary Research in Biomedicine, ICBAS - School of Medicine and Biomedical Sciences, University of Porto, Rua Jorge de Viterbo Ferreira 228, Porto, Portugal"},{"name":"Laboratory for Integrative and Translational Research in Population Health (ITR) , University of Porto, Rua das Taipas 136, Porto, Portugal"},{"name":"LAQV & REQUIMTE , Department of Chemistry, University of Aveiro, Aveiro, Portugal"},{"name":"Department of Pathology , Faculty of Medicine, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1941-6634","authenticated-orcid":false,"given":"Raquel L","family":"Bernardino","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Endocrinology , UMIB - Unit for Multidisciplinary Research in Biomedicine, ICBAS - School of Medicine and Biomedical Sciences, University of Porto, Rua Jorge de Viterbo Ferreira 228, Porto, Portugal"},{"name":"Laboratory for Integrative and Translational Research in Population Health (ITR) , University of Porto, Rua das Taipas 136, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno S","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Endocrinology , UMIB - Unit for Multidisciplinary Research in Biomedicine, ICBAS - School of Medicine and Biomedical Sciences, University of Porto, Rua Jorge de Viterbo Ferreira 228, Porto, Portugal"},{"name":"Laboratory for Integrative and Translational Research in Population Health (ITR) , University of Porto, Rua das Taipas 136, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8700-3698","authenticated-orcid":false,"given":"Alberto","family":"Barros","sequence":"additional","affiliation":[{"name":"Department of Pathology , Faculty of Medicine, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, Porto, Portugal"},{"name":"i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade , University of Porto, R. 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