{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:59:37Z","timestamp":1790272777145,"version":"4.1.0"},"reference-count":147,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":483,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>\u2003<\/jats:title>\n                  <jats:sec>\n                    <jats:title>In brief<\/jats:title>\n                    <jats:p>Chromosome missegregation and declining energy metabolism are considered to be unrelated features of oocyte ageing that contribute to poor reproductive outcomes. Given the bioenergetic cost of chromosome segregation, we propose here that altered energy metabolism during ageing may be an underlying cause of age-related chromosome missegregation and aneuploidy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Advanced reproductive age in women is a major cause of infertility, miscarriage and congenital abnormalities. This is principally caused by a decrease in oocyte quality and developmental competence with age. Oocyte ageing is characterised by an increase in chromosome missegregation and aneuploidy. However, the underlying mechanisms of age-related aneuploidy have not been fully elucidated and are still under active investigation. In addition to chromosome missegregation, oocyte ageing is also accompanied by metabolic dysfunction. In this review, we integrate old and new perspectives on oocyte ageing, chromosome segregation and metabolism in mammalian oocytes and make direct links between these processes. We consider age-related alterations to chromosome segregation machinery, including the loss of cohesion, microtubule stability and the integrity of the spindle assembly checkpoint. We focus on how metabolic dysfunction in the ageing oocyte disrupts chromosome segregation machinery to contribute to and exacerbate age-related aneuploidy. More specifically, we discuss how mitochondrial function, ATP production and the generation of free radicals are altered during ageing. We also explore recent developments in oocyte metabolic ageing, including altered redox reactions (NAD+ metabolism) and the interactions between oocytes and their somatic nurse cells. Throughout the review, we integrate the mechanisms by which changes in oocyte metabolism influence age-related chromosome missegregation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/rep-23-0510","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T12:37:11Z","timestamp":1715085431000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":26,"title":["Reproductive Ageing: Metabolic contribution to age-related chromosome missegregation in mammalian oocytes"],"prefix":"10.1093","volume":"168","author":[{"given":"Bettina P","family":"Mihalas","sequence":"first","affiliation":[{"name":"Oocyte Biology Research Unit , Discipline of Women\u2019s Health, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Kensington, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele L","family":"Marston","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Cell Biology , Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1599-7574","authenticated-orcid":false,"given":"Lindsay E","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences , Faculty of Medicine and Health, UNSW Sydney, Kensington, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B","family":"Gilchrist","sequence":"additional","affiliation":[{"name":"Oocyte Biology Research Unit , Discipline of Women\u2019s Health, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Kensington, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"2026010712104478300_bib1","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1038\/s41467-021-21644-z","article-title":"Epidermal growth factor receptor signaling uncouples germ cells from the somatic follicular compartment at ovulation","volume":"12","author":"Abbassi","year":"2021","journal-title":"Nature Communications"},{"key":"2026010712104478300_bib2","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1002\/mrd.20121","article-title":"Regulation of histone acetylation during meiotic maturation in mouse oocytes","volume":"69","author":"Akiyama","year":"2004","journal-title":"Molecular Reproduction and Development"},{"key":"2026010712104478300_bib3","doi-asserted-by":"publisher","first-page":"7339","DOI":"10.1073\/pnas.0510946103","article-title":"Inadequate histone deacetylation during oocyte meiosis causes aneuploidy and embryo death in mice","volume":"103","author":"Akiyama","year":"2006","journal-title":"PNAS"},{"key":"2026010712104478300_bib4","doi-asserted-by":"publisher","first-page":"800739","DOI":"10.3389\/fphys.2021.800739","article-title":"Role of granulosa cells in the aging ovarian landscape: A focus on mitochondrial and metabolic function","volume":"12","author":"Alberico","year":"2021","journal-title":"Frontiers in Physiology"},{"key":"2026010712104478300_bib5","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1093\/molehr\/gaz055","article-title":"The spatio-temporal dynamics of mitochondrial membrane potential during oocyte maturation","volume":"25","author":"Al-Zubaidi","year":"2019","journal-title":"Molecular Human Reproduction"},{"key":"2026010712104478300_bib6","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1136\/bmj.320.7251.1708","article-title":"Maternal age and fetal loss: population based register linkage study","volume":"320","author":"Andersen","year":"2000","journal-title":"BMJ"},{"key":"2026010712104478300_bib7","doi-asserted-by":"publisher","first-page":"e13259","DOI":"10.1111\/acel.13259","article-title":"Ovarian stiffness increases with age in the mammalian ovary and depends on collagen and hyaluronan matrices","volume":"19","author":"Amargant","year":"2020","journal-title":"Aging Cell"},{"key":"2026010712104478300_bib8","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1093\/biolre\/ioab241","article-title":"Age-associated changes in cumulus cells and follicular fluid: the local oocyte microenvironment as a determinant of gamete quality","volume":"106","author":"Babayev","year":"2022","journal-title":"Biology of Reproduction"},{"key":"2026010712104478300_bib9","doi-asserted-by":"publisher","first-page":"e14004","DOI":"10.1111\/acel.14004","article-title":"Cumulus expansion is impaired with advanced reproductive age due to loss of matrix integrity and reduced hyaluronan","volume":"22","author":"Babayev","year":"2023","journal-title":"Aging Cell"},{"key":"2026010712104478300_bib10","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s10815-009-9376-9","article-title":"Cumulus cell contact during oocyte maturation in mice regulates meiotic spindle positioning and enhances developmental competence","volume":"27","author":"Barrett","year":"2010","journal-title":"Journal of Assisted Reproduction and Genetics"},{"key":"2026010712104478300_bib11","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/s1472-6483(1061946-3","article-title":"Mitochondrial DNA point mutation in human oocytes is associated with maternal age","volume":"1","author":"Barritt","year":"2000","journal-title":"Reproductive Biomedicine Online"},{"key":"2026010712104478300_bib12","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1016\/j.ajog.2005.08.038","article-title":"Higher rate of stillbirth at the extremes of reproductive age: a large nationwide sample of deliveries in the United States","volume":"194","author":"Bateman","year":"2006","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"2026010712104478300_bib13","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1111\/acel.12368","article-title":"Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging","volume":"14","author":"Ben-Meir","year":"2015","journal-title":"Aging Cell"},{"key":"2026010712104478300_bib14","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/nchembio.186","article-title":"Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli","volume":"5","author":"Bennett","year":"2009","journal-title":"Nature Chemical Biology"},{"key":"2026010712104478300_bib15","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1503\/cmaj.071577","article-title":"Advanced maternal age: are decisions about the timing of child-bearing a failure to understand the risks?","volume":"178","author":"Benzies","year":"2008","journal-title":"CMAJ"},{"key":"2026010712104478300_bib16","doi-asserted-by":"publisher","first-page":"1670.e.7","DOI":"10.1016\/j.celrep.2020.01.058","article-title":"NAD(+) repletion rescues female fertility during reproductive aging","volume":"30","author":"Bertoldo","year":"2020","journal-title":"Cell Reports"},{"key":"2026010712104478300_bib17","doi-asserted-by":"publisher","first-page":"CD007176","DOI":"10.1002\/14651858.CD007176.pub2","article-title":"Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases","volume":"2012","author":"Bjelakovic","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"2026010712104478300_bib18","doi-asserted-by":"publisher","first-page":"e13489","DOI":"10.1111\/acel.13489","article-title":"Age-dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase B","volume":"20","author":"Blengini","year":"2021","journal-title":"Aging Cell"},{"key":"2026010712104478300_bib19","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1038\/s43587-023-00435-9","article-title":"Follicular communication breakdown in aging ovaries","volume":"3","author":"Blengini","year":"2023","journal-title":"Nature Aging"},{"key":"2026010712104478300_bib20","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1530\/REP-16-0129","article-title":"Reproductive age-associated fibrosis in the stroma of the mammalian ovary","volume":"152","author":"Briley","year":"2016","journal-title":"Reproduction"},{"key":"2026010712104478300_bib21","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1530\/jrf.0.0240187","article-title":"Oxidation of pyruvate and glucose by oocytes of the mouse and rhesus monkey","volume":"24","author":"Brinster","year":"1971","journal-title":"Journal of Reproduction and Fertility"},{"key":"2026010712104478300_bib22","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.cub.2015.12.073","article-title":"Chromosome cohesion established by Rec8-Cohesin in fetal oocytes is maintained without detectable turnover in oocytes arrested for months in mice","volume":"26","author":"Burkhardt","year":"2016","journal-title":"Current Biology"},{"key":"2026010712104478300_bib23","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1093\/humupd\/dmx010","article-title":"Motoring through: the role of kinesin superfamily proteins in female meiosis","volume":"23","author":"Camlin","year":"2017","journal-title":"Human Reproduction Update"},{"key":"2026010712104478300_bib24","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s10522-022-09957-y","article-title":"Multispectral autofluorescence characteristics of reproductive aging in old and young mouse oocytes","volume":"23","author":"Campbell","year":"2022","journal-title":"Biogerontology"},{"key":"2026010712104478300_bib26","doi-asserted-by":"publisher","first-page":"8935","DOI":"10.1016\/S0021-9258(1938978-1","article-title":"Mechanism of the microtubule GTPase reaction","volume":"265","author":"Caplow","year":"1990","journal-title":"Journal of Biological Chemistry"},{"key":"2026010712104478300_bib25","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1083\/jcb.127.3.779","article-title":"The free energy for hydrolysis of a microtubule-bound nucleotide triphosphate is near zero: all of the free energy for hydrolysis is stored in the microtubule lattice","volume":"127","author":"Caplow","year":"1994","journal-title":"Journal of Cell Biology"},{"key":"2026010712104478300_bib27","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/35060009","article-title":"Ran-GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly","volume":"3","author":"Carazo-Salas","year":"2001","journal-title":"Nature Cell Biology"},{"key":"2026010712104478300_bib28","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.midw.2010.07.006","article-title":"Advanced maternal age and adverse perinatal outcome: a review of the evidence","volume":"27","author":"Carolan","year":"2011","journal-title":"Midwifery"},{"key":"2026010712104478300_bib29","doi-asserted-by":"publisher","first-page":"3343","DOI":"10.1083\/jcb.201801111","article-title":"A quantitative analysis of cohesin decay in mitotic fidelity","volume":"217","author":"Carvalhal","year":"2018","journal-title":"Journal of Cell Biology"},{"key":"2026010712104478300_bib30","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.rbmo.2021.08.006","article-title":"Reproductive senescence impairs the energy metabolism of human luteinized granulosa cells","volume":"43","author":"Cecchino","year":"2021","journal-title":"Reproductive Biomedicine Online"},{"key":"2026010712104478300_bib31","doi-asserted-by":"publisher","first-page":"3797","DOI":"10.1242\/jcs.084855","article-title":"RanGTP is required for meiotic spindle organization and the initiation of embryonic development in Drosophila","volume":"124","author":"Cesario","year":"2011","journal-title":"Journal of Cell Science"},{"key":"2026010712104478300_bib32","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1093\/molehr\/gah243","article-title":"Mitochondrial DNA content and 4977 bp deletion in unfertilized oocytes","volume":"11","author":"Chan","year":"2005","journal-title":"Molecular Human Reproduction"},{"key":"2026010712104478300_bib33","doi-asserted-by":"publisher","first-page":"4038","DOI":"10.1016\/j.cub.2021.06.076","article-title":"Ovulation suppression protects against chromosomal abnormalities in mouse eggs at advanced maternal age","volume":"31","author":"Chatzidaki","year":"2021","journal-title":"Current Biology"},{"key":"2026010712104478300_bib35","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071578","article-title":"Age-related loss of cohesion: causes and effects","volume":"18","author":"Cheng","year":"2017","journal-title":"International Journal of Molecular Sciences"},{"key":"2026010712104478300_bib34","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1080\/15384101.2017.1327488","article-title":"Merotelic kinetochore attachment in oocyte meiosis II causes sister chromatids segregation errors in aged mice","volume":"16","author":"Cheng","year":"2017","journal-title":"Cell Cycle"},{"key":"2026010712104478300_bib36","doi-asserted-by":"publisher","first-page":"238463","DOI":"10.1155\/2014\/238463","article-title":"Mitochondrial aging and age-related dysfunction of mitochondria","volume":"2014","author":"Chistiakov","year":"2014","journal-title":"BioMed Research International"},{"key":"2026010712104478300_bib37","first-page":"482","article-title":"Telomere length dynamics and the evolution of cancer genome","volume":"19","author":"Cleal","year":"2018","journal-title":"Architecture"},{"key":"2026010712104478300_bib38","doi-asserted-by":"publisher","first-page":"e1010400","DOI":"10.1371\/journal.pgen.1010400","article-title":"Oocyte mitophagy is critical for extended reproductive longevity","volume":"18","author":"Cota","year":"2022","journal-title":"PLoS Genetics"},{"key":"2026010712104478300_bib39","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1002\/pd.5840","article-title":"Maternal age in the epidemiology of common autosomal trisomies","volume":"41","author":"Cuckle","year":"2021","journal-title":"Prenatal Diagnosis"},{"key":"2026010712104478300_bib40","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1002\/jcp.24457","article-title":"Measurement of ATP in single oocytes: impact of maturation and cumulus cells on levels and consumption","volume":"229","author":"Dalton","year":"2014","journal-title":"Journal of Cellular Physiology"},{"key":"2026010712104478300_bib41","doi-asserted-by":"publisher","first-page":"576","DOI":"10.4161\/cc.6.5.3934","article-title":"Oxidative stress overrides the spindle checkpoint","volume":"6","author":"D'angiolella","year":"2007","journal-title":"Cell Cycle"},{"key":"2026010712104478300_bib42","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1038\/s41586-023-05922-y","article-title":"Ageing-associated changes in transcriptional elongation influence longevity","volume":"616","author":"Debes","year":"2023","journal-title":"Nature"},{"key":"2026010712104478300_bib43","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1006\/dbio.1995.1044","article-title":"The influence of glucose, cumulus cells, and metabolic coupling on ATP levels and meiotic control in the isolated mouse oocyte","volume":"167","author":"Downs","year":"1995","journal-title":"Developmental Biology"},{"key":"2026010712104478300_bib44","doi-asserted-by":"publisher","first-page":"e101689","DOI":"10.15252\/embj.2019101689","article-title":"RanGTP and importin beta regulate meiosis I spindle assembly and function in mouse oocytes","volume":"39","author":"Drutovic","year":"2020","journal-title":"EMBO Journal"},{"key":"2026010712104478300_bib45","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1111\/acel.12676","article-title":"Age-associated dysregulation of protein metabolism in the mammalian oocyte","volume":"16","author":"Duncan","year":"2017","journal-title":"Aging Cell"},{"key":"2026010712104478300_bib46","doi-asserted-by":"publisher","first-page":"eadc9161","DOI":"10.1126\/sciadv.adc9161","article-title":"Actin limits egg aneuploidies associated with female reproductive aging","volume":"9","author":"Dunkley","year":"2023","journal-title":"Science Advances"},{"key":"2026010712104478300_bib47","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1101\/gad.255554.114","article-title":"From equator to pole: splitting chromosomes in mitosis and meiosis","volume":"29","author":"Duro","year":"2015","journal-title":"Genes and Development"},{"key":"2026010712104478300_bib48","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.3390\/cells9061550","article-title":"Nicotinamide supplementation during the in vitro maturation of oocytes improves the developmental competence of preimplantation embryos: potential link to SIRT1\/AKT signaling","volume":"9","author":"El Sheikh","year":"2020","journal-title":"Cells"},{"key":"2026010712104478300_bib49","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1016\/j.cub.2018.02.039","article-title":"Mammalian oocytes locally remodel follicular architecture to provide the foundation for germline-soma communication","volume":"28","author":"El-Hayek","year":"2018","journal-title":"Current Biology"},{"key":"2026010712104478300_bib50","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1002\/mrd.20288","article-title":"Changes in histone modifications during in vitro maturation of porcine oocytes","volume":"71","author":"Endo","year":"2005","journal-title":"Molecular Reproduction and Development"},{"key":"2026010712104478300_bib51","doi-asserted-by":"publisher","first-page":"e167","DOI":"10.1016\/j.fertnstert.2021.07.463","article-title":"Addition of rapamycin and young granulosa cells to improve in vitro oocyte maturation and euploidy rates in older reproductive age women: a prospective randomized study","volume":"116","author":"Esbert","year":"2021","journal-title":"Fertility and Sterility"},{"key":"2026010712104478300_bib52","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.cell.2014.03.026","article-title":"Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)\/SIRT1 reduction","volume":"157","author":"Fang","year":"2014","journal-title":"Cell"},{"key":"2026010712104478300_bib53","author":"Fitzgerald","year":"2017","journal-title":"Assisted Reproductive Technology in Australia and New Zealand 2010"},{"key":"2026010712104478300_bib54","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1002\/mrd.22042","article-title":"The importance of mitochondrial metabolic activity and mitochondrial DNA replication during oocyte maturation in vitro on oocyte quality and subsequent embryo developmental competence","volume":"79","author":"Ge","year":"2012","journal-title":"Molecular Reproduction and Development"},{"key":"2026010712104478300_bib55","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1089\/ars.2013.5228","article-title":"The free radical theory of aging is dead. Long live the damage theory!","volume":"20","author":"Gladyshev","year":"2014","journal-title":"Antioxidants and Redox Signaling"},{"key":"2026010712104478300_bib56","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.xfss.2023.05.004","article-title":"Cumulus cell co-culture in media drops does not improve rescue in vitro maturation of vitrified-warmed immature oocytes","volume":"4","author":"Gordon","year":"2023","journal-title":"F&S Science"},{"key":"2026010712104478300_bib57","doi-asserted-by":"publisher","first-page":"102701","DOI":"10.1016\/j.redox.2023.102701","article-title":"The establishment of mitotic errors-driven senescence depends on autophagy","volume":"62","author":"Goutas","year":"2023","journal-title":"Redox Biology"},{"key":"2026010712104478300_bib58","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1093\/humupd\/dmx035","article-title":"Regulation of chromosome segregation in oocytes and the cellular basis for female meiotic errors","volume":"24","author":"Greaney","year":"2018","journal-title":"Human Reproduction Update"},{"key":"2026010712104478300_bib59","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1126\/science.aav7321","article-title":"Chromosome errors in human eggs shape natural fertility over reproductive life span","volume":"365","author":"Gruhn","year":"2019","journal-title":"Science"},{"key":"2026010712104478300_bib60","doi-asserted-by":"publisher","first-page":"e106797","DOI":"10.15252\/embj.2020106797","article-title":"Kinetochore individualization in meiosis I is required for centromeric cohesin removal in meiosis II","volume":"40","author":"Gryaznova","year":"2021","journal-title":"EMBO Journal"},{"key":"2026010712104478300_bib61","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.celrep.2017.12.042","article-title":"Ca(2+)-induced mitochondrial ROS Regulate the early embryonic cell cycle","volume":"22","author":"Han","year":"2018","journal-title":"Cell Reports"},{"key":"2026010712104478300_bib62","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1196\/annals.1354.003","article-title":"Free radical theory of aging: an update: increasing the functional life span","volume":"1067","author":"Harman","year":"2006","journal-title":"Annals of the New York Academy of Sciences"},{"key":"2026010712104478300_bib63","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1023\/a:1022458010266","article-title":"ADP-regulation of mitochondrial free radical production is different with complex I- or complex II-linked substrates: implications for the exercise paradox and brain hypermetabolism","volume":"29","author":"Herrero","year":"1997","journal-title":"Journal of Bioenergetics and Biomembranes"},{"key":"2026010712104478300_bib64","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1126\/science.aaa9529","article-title":"Human oocytes. Error-prone chromosome-mediated spindle assembly favors chromosome segregation defects in human oocytes","volume":"348","author":"Holubcova","year":"2015","journal-title":"Science"},{"key":"2026010712104478300_bib65","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/nature12188","article-title":"Mitonuclear protein imbalance as a conserved longevity mechanism","volume":"497","author":"Houtkooper","year":"2013","journal-title":"Nature"},{"key":"2026010712104478300_bib66","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1038\/35001622","article-title":"Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase","volume":"403","author":"Imai","year":"2000","journal-title":"Nature"},{"key":"2026010712104478300_bib67","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1080\/15548627.2021.1946739","article-title":"RAB7 activity is required for the regulation of mitophagy in oocyte meiosis and oocyte quality control during ovarian aging","volume":"18","author":"Jin","year":"2022","journal-title":"Autophagy"},{"key":"2026010712104478300_bib68","doi-asserted-by":"publisher","first-page":"2452","DOI":"10.1126\/science.1068798","article-title":"Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts","volume":"295","author":"Kalab","year":"2002","journal-title":"Science"},{"key":"2026010712104478300_bib69","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaad028","article-title":"Control of mitochondrial integrity influences oocyte quality during reproductive aging","volume":"29","author":"Khan","year":"2023","journal-title":"Molecular Human Reproduction"},{"key":"2026010712104478300_bib70","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1083\/jcb.200303047","article-title":"Changes in histone acetylation during mouse oocyte meiosis","volume":"162","author":"Kim","year":"2003","journal-title":"Journal of Cell Biology"},{"key":"2026010712104478300_bib71","doi-asserted-by":"publisher","first-page":"160","DOI":"10.5468\/ogs.2013.56.3.160","article-title":"Maternal age-specific rates of fetal chromosomal abnormalities in Korean pregnant women of advanced maternal age","volume":"56","author":"Kim","year":"2013","journal-title":"Obstetrics and Gynecology Science"},{"key":"2026010712104478300_bib72","doi-asserted-by":"publisher","first-page":"4127","DOI":"10.1074\/jbc.M310341200","article-title":"Characterization of superoxide-producing sites in isolated brain mitochondria","volume":"279","author":"Kudin","year":"2004","journal-title":"Journal of Biological Chemistry"},{"key":"2026010712104478300_bib73","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.rbmo.2010.08.014","article-title":"Meiosis errors in over 20,000 oocytes studied in the practice of preimplantation aneuploidy testing","volume":"22","author":"Kuliev","year":"2011","journal-title":"Reproductive Biomedicine Online"},{"key":"2026010712104478300_bib74","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1530\/jrf.0.0720009","article-title":"Pyruvate and glucose uptake by mouse ova and preimplantation embryos","volume":"72","author":"Leese","year":"1984","journal-title":"Journal of Reproduction and Fertility"},{"key":"2026010712104478300_bib75","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1002\/jez.1402340208","article-title":"Production of pyruvate by isolated mouse cumulus cells","volume":"234","author":"Leese","year":"1985","journal-title":"Journal of Experimental Zoology"},{"key":"2026010712104478300_bib76","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1095\/biolreprod63.3.839","article-title":"Oocyte-secreted factor(s) determine functional differences between bovine mural granulosa cells and cumulus cells","volume":"63","author":"Li","year":"2000","journal-title":"Biology of Reproduction"},{"key":"2026010712104478300_bib77","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1016\/j.cub.2010.08.023","article-title":"Age-related meiotic segregation errors in mammalian oocytes are preceded by depletion of cohesin and Sgo2","volume":"20","author":"Lister","year":"2010","journal-title":"Current Biology"},{"key":"2026010712104478300_bib79","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1093\/embo-reports\/kvf055","article-title":"Requirement of functional telomeres for metaphase chromosome alignments and integrity of meiotic spindles","volume":"3","author":"Liu","year":"2002","journal-title":"EMBO Reports"},{"key":"2026010712104478300_bib78","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1038\/s43587-023-00419-9","article-title":"Granulosa cell mevalonate pathway abnormalities contribute to oocyte meiotic defects and aneuploidy","volume":"3","author":"Liu","year":"2023","journal-title":"Nature Aging"},{"key":"2026010712104478300_bib80","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.114.122820","article-title":"Accumulation of electrophilic aldehydes during postovulatory aging of mouse oocytes causes reduced fertility, oxidative stress, and Apoptosis1","volume":"92","author":"Lord","year":"2015","journal-title":"Biology of Reproduction"},{"key":"2026010712104478300_bib81","doi-asserted-by":"publisher","first-page":"8706","DOI":"10.1038\/ncomms9706","article-title":"DNA damage-induced metaphase I arrest is mediated by the spindle assembly checkpoint and maternal age","volume":"6","author":"Marangos","year":"2015","journal-title":"Nature Communications"},{"key":"2026010712104478300_bib82","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/s41580-023-00593-z","article-title":"Principles and dynamics of spindle assembly checkpoint signalling","volume":"24","author":"Mcainsh","year":"2023","journal-title":"Nature Reviews"},{"key":"2026010712104478300_bib83","doi-asserted-by":"publisher","first-page":"107987","DOI":"10.1016\/j.celrep.2020.107987","article-title":"Nicotinamide mononucleotide supplementation reverses the declining quality of maternally aged oocytes","volume":"32","author":"Miao","year":"2020","journal-title":"Cell Reports"},{"key":"2026010712104478300_bib84","doi-asserted-by":"publisher","first-page":"e57227","DOI":"10.15252\/embr.202357227","article-title":"Spindle assembly checkpoint insensitivity allows meiosis-II despite chromosomal defects in aged eggs","volume":"24","author":"Mihajlovi\u0107","year":"2023","journal-title":"EMBO Reports"},{"key":"2026010712104478300_bib85","doi-asserted-by":"publisher","first-page":"6247","DOI":"10.1038\/s41598-017-06372-z","article-title":"The lipid peroxidation product 4-hydroxynonenal contributes to oxidative stress-mediated deterioration of the ageing oocyte","volume":"7","author":"Mihalas","year":"2017","journal-title":"Scientific Reports"},{"key":"2026010712104478300_bib86","doi-asserted-by":"publisher","first-page":"4015874","DOI":"10.1155\/2017\/4015874","article-title":"Molecular mechanisms responsible for increased vulnerability of the ageing oocyte to oxidative damage","volume":"2017","author":"Mihalas","year":"2017","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"2026010712104478300_bib88","doi-asserted-by":"publisher","first-page":"5162","DOI":"10.1096\/fj.201902184R","article-title":"Dynamin 2-dependent endocytosis is essential for mouse oocyte development and fertility","volume":"34","author":"Mihalas","year":"2020","journal-title":"FASEB Journal"},{"key":"2026010712104478300_bib87","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.cub.2023.11.061","article-title":"Age-dependent loss of cohesion protection in","volume":"34","author":"Mihalas","year":"2024","journal-title":"Current Biology"},{"key":"2026010712104478300_bib89","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1146\/annurev-cellbio-100616-060553","article-title":"Assembly and positioning of the oocyte meiotic spindle","volume":"34","author":"Mogessie","year":"2018","journal-title":"Annual Review of Cell and Developmental Biology"},{"key":"2026010712104478300_bib90","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1016\/j.cub.2017.02.025","article-title":"Intrinsically defective microtubule dynamics contribute to age-related chromosome segregation errors in mouse oocyte meiosis-I","volume":"27","author":"Nakagawa","year":"2017","journal-title":"Current Biology"},{"key":"2026010712104478300_bib91","author":"Newman","year":"2022","journal-title":"Assisted Reproductive Technology in Australia and New Zealand 2020"},{"key":"2026010712104478300_bib92","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1016\/j.cub.2022.03.041","article-title":"Aurora B\/C-dependent phosphorylation promotes Rec8 cleavage in mammalian oocytes","volume":"32","author":"Nikalayevich","year":"2022","journal-title":"Current Biology"},{"key":"2026010712104478300_bib93","doi-asserted-by":"publisher","first-page":"8729","DOI":"10.1073\/pnas.1607498113","article-title":"Spatial organization of the Ran pathway by microtubules in mitosis","volume":"113","author":"Oh","year":"2016","journal-title":"PNAS"},{"key":"2026010712104478300_bib94","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1002\/jcb.22736","article-title":"Reactive oxygen and nitrogen species during meiotic resumption from diplotene arrest in mammalian oocytes","volume":"111","author":"Pandey","year":"2010","journal-title":"Journal of Cellular Biochemistry"},{"key":"2026010712104478300_bib95","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1038\/nchembio.2077","article-title":"Metabolite concentrations, fluxes and free energies imply efficient enzyme usage","volume":"12","author":"Park","year":"2016","journal-title":"Nature Chemical Biology"},{"key":"2026010712104478300_bib96","first-page":"1","article-title":"ATP depletion during mitotic arrest induces mitotic slippage and APC\/C(Cdh1)-dependent cyclin B1 degradation","volume":"50","author":"Park","year":"2018","journal-title":"Experimental and Molecular Medicine"},{"key":"2026010712104478300_bib97","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1242\/bio.016394","article-title":"Unique geometry of sister kinetochores in human oocytes during meiosis I may explain maternal age-associated increases in chromosomal abnormalities","volume":"5","author":"Patel","year":"2015","journal-title":"Biology Open"},{"key":"2026010712104478300_bib98","doi-asserted-by":"publisher","first-page":"2781","DOI":"10.1093\/humrep\/12.12.2781","article-title":"Cumulus cells are required for the increased apoptotic potential in oocytes of aged mice","volume":"12","author":"Perez","year":"1997","journal-title":"Human Reproduction"},{"key":"2026010712104478300_bib99","doi-asserted-by":"publisher","first-page":"E6823","DOI":"10.1073\/pnas.1612047113","article-title":"Oxidative stress in oocytes during midprophase induces premature loss of cohesion and chromosome segregation errors","volume":"113","author":"Perkins","year":"2016","journal-title":"PNAS"},{"key":"2026010712104478300_bib100","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1262\/jrd.2021-080","article-title":"Supplementing media with NAD(+) precursors enhances the in vitro maturation of porcine oocytes","volume":"67","author":"Pollard","year":"2021","journal-title":"Journal of Reproduction and Development"},{"key":"2026010712104478300_bib101","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1262\/jrd.2021-130","article-title":"Insights into the NAD(+) biosynthesis pathways involved during meiotic maturation and spindle formation in porcine oocytes","volume":"68","author":"Pollard","year":"2022","journal-title":"Journal of Reproduction and Development"},{"key":"2026010712104478300_bib102","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.theriogenology.2014.01.020","article-title":"Advancing maternal age predisposes to mitochondrial damage and loss during maturation of equine oocytes in vitro","volume":"81","author":"Rambags","year":"2014","journal-title":"Theriogenology"},{"key":"2026010712104478300_bib104","doi-asserted-by":"publisher","first-page":"18395","DOI":"10.1038\/s41598-019-54693-y","article-title":"Participation of the adenosine salvage pathway and cyclic AMP modulation in oocyte energy metabolism","volume":"9","author":"Richani","year":"2019","journal-title":"Scientific Reports"},{"key":"2026010712104478300_bib103","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/humupd\/dmaa043","article-title":"Metabolic co-dependence of the oocyte and cumulus cells: essential role in determining oocyte developmental competence","volume":"27","author":"Richani","year":"2021","journal-title":"Human Reproduction Update"},{"key":"2026010712104478300_bib105","doi-asserted-by":"publisher","first-page":"8665","DOI":"10.1073\/pnas.0903485106","article-title":"Antioxidants prevent health-promoting effects of physical exercise in humans","volume":"106","author":"Ristow","year":"2009","journal-title":"PNAS"},{"key":"2026010712104478300_bib106","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1038\/s41586-022-04979-5","article-title":"Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex I","volume":"607","author":"Rodriguez-Nuevo","year":"2022","journal-title":"Nature"},{"key":"2026010712104478300_bib107","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/nature09787","article-title":"Telomere dysfunction induces metabolic and mitochondrial compromise","volume":"470","author":"Sahin","year":"2011","journal-title":"Nature"},{"key":"2026010712104478300_bib108","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.cmet.2007.08.011","article-title":"Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress","volume":"6","author":"Schulz","year":"2007","journal-title":"Cell Metabolism"},{"key":"2026010712104478300_bib109","doi-asserted-by":"publisher","first-page":"140869","DOI":"10.1016\/j.bbapap.2022.140869","article-title":"Effect of tubulin self-association on GTP hydrolysis and nucleotide exchange reactions","volume":"1871","author":"Shemesh","year":"2023","journal-title":"Biochimica et Biophysica Acta. Proteins and Proteomics"},{"key":"2026010712104478300_bib110","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1073\/pnas.1017213108","article-title":"Reactive oxygen species are indispensable in ovulation","volume":"108","author":"Shkolnik","year":"2011","journal-title":"PNAS"},{"key":"2026010712104478300_bib111","doi-asserted-by":"publisher","first-page":"CD007807","DOI":"10.1002\/14651858.CD007807.pub4","article-title":"Antioxidants for female subfertility","volume":"8","author":"Showell","year":"2020","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"2026010712104478300_bib112","doi-asserted-by":"publisher","first-page":"e64955","DOI":"10.1371\/journal.pone.0064955","article-title":"Age-associated metabolic and morphologic changes in mitochondria of individual mouse and hamster oocytes","volume":"8","author":"Simsek-Duran","year":"2013","journal-title":"PLoS One"},{"key":"2026010712104478300_bib113","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1093\/humrep\/dead177","article-title":"Human ovarian aging is characterized by oxidative damage and mitochondrial dysfunction","volume":"38","author":"Smits","year":"2023","journal-title":"Human Reproduction"},{"key":"2026010712104478300_bib114","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1021\/tx700106v","article-title":"Residue-specific adduction of tubulin by 4-hydroxynonenal and 4-oxononenal causes cross-linking and inhibits polymerization","volume":"20","author":"Stewart","year":"2007","journal-title":"Chemical Research in Toxicology"},{"key":"2026010712104478300_bib115","doi-asserted-by":"publisher","first-page":"44784","DOI":"10.1074\/jbc.M207217200","article-title":"Topology of superoxide production from different sites in the mitochondrial electron transport chain","volume":"277","author":"St-Pierre","year":"2002","journal-title":"Journal of Biological Chemistry"},{"key":"2026010712104478300_bib116","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/2046-2395-3-4","article-title":"A midlife crisis for the mitochondrial free radical theory of aging","volume":"3","author":"Stuart","year":"2014","journal-title":"Longevity and Healthspan"},{"key":"2026010712104478300_bib117","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1007\/s10815-023-02779-y","article-title":"Morphokinetic parameters of mouse oocyte meiotic maturation and cumulus expansion are not affected by reproductive age or ploidy status","volume":"40","author":"Suebthawinkul","year":"2023","journal-title":"Journal of Assisted Reproduction and Genetics"},{"key":"2026010712104478300_bib118","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1101\/gad.605910","article-title":"Rec8-containing cohesin maintains bivalents without turnover during the growing phase of mouse oocytes","volume":"24","author":"Tachibana-Konwalski","year":"2010","journal-title":"Genes and Development"},{"key":"2026010712104478300_bib119","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1007\/s10815-016-0716-2","article-title":"Dynamic changes in mitochondrial distribution in human oocytes during meiotic maturation","volume":"33","author":"Takahashi","year":"2016","journal-title":"Journal of Assisted Reproduction and Genetics"},{"key":"2026010712104478300_bib120","doi-asserted-by":"publisher","first-page":"15812","DOI":"10.1074\/jbc.M114.632141","article-title":"Inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, leads to altered carbohydrate metabolism in cancer cells","volume":"290","author":"Tan","year":"2015","journal-title":"Journal of Biological Chemistry"},{"key":"2026010712104478300_bib121","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1042\/BST20200043","article-title":"Aneuploidy in human eggs: contributions of the meiotic spindle","volume":"49","author":"Thomas","year":"2021","journal-title":"Biochemical Society Transactions"},{"key":"2026010712104478300_bib122","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1111\/jog.12938","article-title":"Moderate increase of reactive oxygen species triggers meiotic resumption in rat follicular oocytes","volume":"42","author":"Tiwari","year":"2016","journal-title":"Journal of Obstetrics and Gynaecology Research"},{"key":"2026010712104478300_bib123","doi-asserted-by":"publisher","first-page":"e1002161","DOI":"10.1371\/journal.pgen.1002161","article-title":"Telomere DNA deficiency is associated with development of human embryonic aneuploidy","volume":"7","author":"Treff","year":"2011","journal-title":"PLoS Genetics"},{"key":"2026010712104478300_bib124","first-page":"491","article-title":"Mitochondria DNA deletion and copy numbers of cumulus cells associated with in vitro fertilization outcomes","volume":"55","author":"Tsai","year":"2010","journal-title":"Journal of Reproductive Medicine"},{"key":"2026010712104478300_bib125","doi-asserted-by":"publisher","first-page":"eabn4564","DOI":"10.1126\/sciadv.abn4564","article-title":"Female reproductive life span is extended by targeted removal of fibrotic collagen from the mouse ovary","volume":"8","author":"Umehara","year":"2022","journal-title":"Science Advances"},{"key":"2026010712104478300_bib126","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1002\/aja.1001710309","article-title":"Mitochondrial reorganization during resumption of arrested meiosis in the mouse oocyte","volume":"171","author":"Van Blerkom","year":"1984","journal-title":"American Journal of Anatomy"},{"key":"2026010712104478300_bib127","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1093\/humrep\/der030","article-title":"Defective deacetylation of histone 4 K12 in human oocytes is associated with advanced maternal age and chromosome misalignment","volume":"26","author":"Van Den Berg","year":"2011","journal-title":"Human Reproduction"},{"key":"2026010712104478300_bib128","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1038\/s41467-018-04003-3","article-title":"Proteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress","volume":"9","author":"Van Der Reest","year":"2018","journal-title":"Nature Communications"},{"key":"2026010712104478300_bib129","doi-asserted-by":"publisher","first-page":"101378","DOI":"10.1016\/j.arr.2021.101378","article-title":"Mitochondria: their relevance during oocyte ageing","volume":"70","author":"Van Der Reest","year":"2021","journal-title":"Ageing Research Reviews"},{"key":"2026010712104478300_bib130","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1002\/mrd.23437","article-title":"Sirtuins in female meiosis and in reproductive longevity","volume":"87","author":"Vazquez","year":"2020","journal-title":"Molecular Reproduction and Development"},{"key":"2026010712104478300_bib131","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1016\/S0006-3495(9778782-4","article-title":"Thermodynamic and structural analysis of microtubule assembly: the role of GTP hydrolysis","volume":"72","author":"Vulevic","year":"1997","journal-title":"Biophysical Journal"},{"key":"2026010712104478300_bib132","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.cell.2020.01.009","article-title":"Single-cell transcriptomic atlas of primate ovarian aging","volume":"180","author":"Wang","year":"2020","journal-title":"Cell"},{"key":"2026010712104478300_bib133","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23052880","article-title":"Chromosome segregation in the oocyte: what goes wrong during aging","volume":"23","author":"Wasielak-Politowska","year":"2022","journal-title":"International Journal of Molecular Sciences"},{"key":"2026010712104478300_bib134","doi-asserted-by":"publisher","first-page":"3393","DOI":"10.1038\/s41467-020-17088-6","article-title":"Nampt-mediated spindle sizing secures a post-anaphase increase in spindle speed required for extreme asymmetry","volume":"11","author":"Wei","year":"2020","journal-title":"Nature Communications"},{"key":"2026010712104478300_bib135","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1093\/humrep\/16.5.909","article-title":"Mitochondrial aggregation patterns and activity in human oocytes and preimplantation embryos","volume":"16","author":"Wilding","year":"2001","journal-title":"Human Reproduction"},{"key":"2026010712104478300_bib136","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1093\/humrep\/deaa128","article-title":"The PARP inhibitor, olaparib, depletes the ovarian reserve in mice: implications for fertility preservation","volume":"35","author":"Winship","year":"2020","journal-title":"Human Reproduction"},{"key":"2026010712104478300_bib137","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/s41422-018-0009-7","article-title":"Poly(ADP-ribose) mediates asymmetric division of mouse oocyte","volume":"28","author":"Xie","year":"2018","journal-title":"Cell Research"},{"key":"2026010712104478300_bib138","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/1477-7827-11-108","article-title":"Age-associated telomere shortening in mouse oocytes","volume":"11","author":"Yamada-Fukunaga","year":"2013","journal-title":"Reproductive Biology and Endocrinology: RB&E"},{"key":"2026010712104478300_bib139","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2020.05.003","article-title":"Increasing ovarian NAD(+) levels improve mitochondrial functions and reverse ovarian aging","volume":"156","author":"Yang","year":"2020","journal-title":"Free Radical Biology and Medicine"},{"key":"2026010712104478300_bib140","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1007\/s43032-021-00532-3","article-title":"The ratio of mitochondrial DNA to genomic DNA copy number in cumulus cell may serve as a biomarker of embryo quality in IVF cycles","volume":"28","author":"Yang","year":"2021","journal-title":"Reproductive Sciences"},{"key":"2026010712104478300_bib141","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.4161\/cc.28897","article-title":"Reduced ability to recover from spindle disruption and loss of kinetochore spindle assembly checkpoint proteins in oocytes from aged mice","volume":"13","author":"Yun","year":"2014","journal-title":"Cell Cycle"},{"key":"2026010712104478300_bib142","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1038\/sj.cr.7310095","article-title":"Deficit of mitochondria-derived ATP during oxidative stress impairs mouse MII oocyte spindles","volume":"16","author":"Zhang","year":"2006","journal-title":"Cell Research"},{"key":"2026010712104478300_bib143","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/S0967199420000192","article-title":"Dynamic alterations in H4K12 acetylation during meiotic maturation and after parthenogenetic activation of mouse oocytes","author":"Zhang","year":"2020","journal-title":"Zygote"},{"key":"2026010712104478300_bib144","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/s41420-023-01539-2","article-title":"Aging-related aneuploidy is associated with mitochondrial imbalance and failure of spindle assembly","volume":"9","author":"Zhang","year":"2023","journal-title":"Cell Death Discovery"},{"key":"2026010712104478300_bib145","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1038\/s43587-023-00498-8","article-title":"Polyamine metabolite spermidine rejuvenates oocyte quality by enhancing mitophagy during female reproductive aging","volume":"3","author":"Zhang","year":"2023","journal-title":"Nature Aging"},{"key":"2026010712104478300_bib146","doi-asserted-by":"publisher","first-page":"4411","DOI":"10.1093\/emboj\/cdf445","article-title":"A mitochondrial specific stress response in mammalian cells","volume":"21","author":"Zhao","year":"2002","journal-title":"EMBO Journal"},{"key":"2026010712104478300_bib147","doi-asserted-by":"publisher","first-page":"e11389","DOI":"10.7554\/eLife.11389","article-title":"Sister kinetochore splitting and precocious disintegration of bivalents could explain the maternal age effect","volume":"4","author":"Zielinska","year":"2015","journal-title":"eLife"}],"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rep.bioscientifica.com\/view\/journals\/rep\/168\/2\/REP-23-0510.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rep.bioscientifica.com\/downloadpdf\/journals\/rep\/168\/2\/REP-23-0510.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/168\/2\/e230510\/64911382\/rep-23-0510.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/168\/2\/e230510\/64911382\/rep-23-0510.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T17:10:48Z","timestamp":1767805848000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/doi\/10.1530\/REP-23-0510\/8217316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,28]]},"references-count":147,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,8,1]]}},"URL":"https:\/\/doi.org\/10.1530\/rep-23-0510","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,6,28]]},"published":{"date-parts":[[2024,6,28]]},"article-number":"e230510"}}