{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T08:21:56Z","timestamp":1768810916595,"version":"3.49.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":555,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:title>\u2003<\/jats:title>\n                  <jats:sec>\n                    <jats:title>In brief<\/jats:title>\n                    <jats:p>Standard in vitro produced (IVP) bovine embryo culture media limit embryonic development. Culturing IVP bovine embryos in standard IVP bovine embryo culture media conditioned with oviduct and\/or endometrial cells improves blastocyst formation and reduces the time to formation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>In vitro embryo production in cattle greatly impacts blastomere biochemistry, embryo rate of development and pre- and post-transfer survival. In vivo, the bovine embryo migrates through the oviduct isthmus before entering the uterus on approximately day 4 of development where it remains unattached within the uterine lumen until day 20 of gestation. During this time, the embryo is sequentially exposed to oviduct followed by endometrial secretions that support embryonic development. Considering this, we tested the effect of culturing in vitro produced (IVP) bovine embryos sequentially in oviduct epithelial- (OEp; days 1\u20133) followed by endometrial epithelial- (EEp) or EEp and fibroblast cell (EEp\/F; days 4\u20138)-conditioned media on embryonic development using a time-lapse monitoring system. Compared to control, culturing IVP embryos in EEp- or EEp\/F-conditioned media without prior culture in OEp-conditioned media increased blastocyst formation (P &amp;lt; 0.05) and reduced the time to blastocyst formation (P &amp;lt; 0.05). Culturing IVP bovine embryos in OEp-conditioned media followed by EEp- or EEp\/F-conditioned media, however, had the greatest impact on embryo developmental kinetics and increased morula and blastocyst formation (P &amp;lt; 0.05) and reduced time to formation (P &amp;lt; 0.05). Day 8 blastocyst cell numbers, diameter and quality were not significantly different, although, blastocyst quality scores were less (indicative of better quality) for all cell-conditioned media compared to control. In conclusion, IVP bovine embryo development may be improved using a sequential embryo culture system involving bovine oviduct followed by endometrial cell-conditioned media.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/rep-24-0008","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T13:01:56Z","timestamp":1709816516000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":6,"title":["Oviduct and endometrial epithelium improve\n                    <i>in vitro<\/i>\n                    produced bovine embryo developmental kinetics"],"prefix":"10.1093","volume":"167","author":[{"given":"L Kirsten","family":"Senn","sequence":"first","affiliation":[{"name":"Department of Animal Science , University of Tennessee Institute of Agriculture, University of Tennessee, Knoxville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katheryn D","family":"Peterson","sequence":"additional","affiliation":[{"name":"Department of Animal Science , University of Tennessee Institute of Agriculture, University of Tennessee, Knoxville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J Lannett","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Animal Science , University of Tennessee Institute of Agriculture, University of Tennessee, Knoxville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca R","family":"Payton","sequence":"additional","affiliation":[{"name":"Department of Animal Science , University of Tennessee Institute of Agriculture, University of Tennessee, Knoxville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7351-3865","authenticated-orcid":false,"given":"Daniel J","family":"Mathew","sequence":"additional","affiliation":[{"name":"Department of Animal Science , University of Tennessee Institute of Agriculture, University of Tennessee, Knoxville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"2026010712112460900_bib1","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1093\/molehr\/gaq056","article-title":"Oviductal secretions: will they be key factors for the future ARTs?","volume":"16","author":"Avil\u00e9s","year":"2010","journal-title":"Molecular Human Reproduction"},{"key":"2026010712112460900_bib2","doi-asserted-by":"publisher","first-page":"14492","DOI":"10.1073\/pnas.1520945114","article-title":"Massive dysregulation of genes involved in cell signaling and placental development in cloned cattle conceptus and maternal endometrium","volume":"113","author":"Biase","year":"2016","journal-title":"PNAS"},{"key":"2026010712112460900_bib3","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1095\/biolreprod63.1.281","article-title":"Amino acids and preimplantation development of the mouse in protein-free potassium simplex optimized medium","volume":"63","author":"Biggers","year":"2000","journal-title":"Biology of Reproduction"},{"key":"2026010712112460900_bib4","first-page":"344","article-title":"Evaluation and classification of bovine embryos","volume":"10","author":"B\u00f3","year":"2013","journal-title":"Animal Reproduction"},{"key":"2026010712112460900_bib5","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1095\/biolreprod.116.141945","article-title":"Analysis of the uterine epithelial and conceptus transcriptome and luminal fluid proteome during the peri-implantation period of pregnancy in Sheep1","volume":"95","author":"Brooks","year":"2016","journal-title":"Biology of Reproduction"},{"key":"2026010712112460900_bib6","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1093\/biolre\/ioy011","article-title":"Progesterone effects on extracellular vesicles in the sheep uterus","volume":"98","author":"Burns","year":"2018","journal-title":"Biology of Reproduction"},{"key":"2026010712112460900_bib7","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1093\/biolre\/ioaa226","article-title":"Conceptus-induced, interferon tau-dependent gene expression in bovine endometrial epithelial and stromal cells\u2020","volume":"104","author":"Chaney","year":"2021","journal-title":"Biology of Reproduction"},{"key":"2026010712112460900_bib8","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1016\/j.fertnstert.2013.06.007","article-title":"Coculturing human endometrial epithelial cells and stromal fibroblasts alters cell-specific gene expression and cytokine production","volume":"100","author":"Chen","year":"2013","journal-title":"Fertility and Sterility"},{"key":"2026010712112460900_bib9","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1016\/j.theriogenology.2014.01.012","article-title":"Development rate and gene expression of IVP bovine embryos cocultured with bovine oviduct epithelial cells at early or late stage of preimplantation development","volume":"81","author":"Cordova","year":"2014","journal-title":"Theriogenology"},{"key":"2026010712112460900_bib10","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/1471-2164-13-118","article-title":"RNA-Seq analysis uncovers transcriptomic variations between morphologically similar in vivo- and in vitro-derived bovine blastocysts","volume":"13","author":"Driver","year":"2012","journal-title":"BMC Genomics"},{"key":"2026010712112460900_bib11","doi-asserted-by":"publisher","first-page":"2555","DOI":"10.1093\/jas\/skz116","article-title":"Board invited review: post-transfer consequences of in vitro-produced embryos in cattle","volume":"97","author":"Ealy","year":"2019","journal-title":"Journal of Animal Science"},{"key":"2026010712112460900_bib12","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1002\/(SICI)1098-2795(199702)46:2&lt;146::AID-MRD5&gt;3.0.CO;2-Q","article-title":"Modifications made to culture medium by bovine oviduct epithelial cells: changes to carbohydrates stimulate bovine embryo development","volume":"46","author":"Edwards","year":"1997","journal-title":"Molecular Reproduction and Development"},{"key":"2026010712112460900_bib13","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1530\/jrf.0.0850715","article-title":"Co-culture of early cattle embryos to the blastocyst stage with oviducal tissue or in conditioned medium","volume":"85","author":"Eyestone","year":"1989","journal-title":"Journal of Reproduction and Fertility"},{"key":"2026010712112460900_bib14","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1095\/biolreprod.112.099697","article-title":"Molecular mechanisms and pathways involved in bovine embryonic genome activation and their regulation by alternative in vivo and in vitro culture conditions","volume":"87","author":"Gad","year":"2012","journal-title":"Biology of Reproduction"},{"key":"2026010712112460900_bib15","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1530\/REP-16-0654","article-title":"Bovine embryo-oviduct interaction in vitro reveals an early cross talk mediated by BMP signaling","volume":"153","author":"Garc\u00eda","year":"2017","journal-title":"Reproduction"},{"key":"2026010712112460900_bib16","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1071\/RD14421","article-title":"Blastocyst metabolism","volume":"27","author":"Gardner","year":"2015","journal-title":"Reproduction, Fertility, and Development"},{"key":"2026010712112460900_bib17","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1095\/biolreprod64.6.1608","article-title":"Endometrial glands are required for preimplantation conceptus elongation and survival","volume":"64","author":"Gray","year":"2001","journal-title":"Biology of Reproduction"},{"key":"2026010712112460900_bib18","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1071\/RD17286","article-title":"Bovine oviductal and uterine fluid support in vitro embryo development","volume":"30","author":"Hamdi","year":"2018","journal-title":"Reproduction, Fertility, and Development"},{"key":"2026010712112460900_bib19","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1095\/biolreprod.106.058826","article-title":"Regulation of gene expression in bovine blastocysts in response to oxygen and the iron chelator desferrioxamine","volume":"77","author":"Harvey","year":"2007","journal-title":"Biology of Reproduction"},{"key":"2026010712112460900_bib20","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1530\/rep.0.1230553","article-title":"Kinetics of early in vitro development of bovine in vivo- and in vitro-derived zygotes produced and\/or cultured in chemically defined or serum-containing media","volume":"123","author":"Holm","year":"2002","journal-title":"Reproduction"},{"key":"2026010712112460900_bib21","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.ydbio.2003.07.014","article-title":"Na+, K+, ATPase activity in the human and bovine preimplantation embryo","volume":"263","author":"Houghton","year":"2003","journal-title":"Developmental Biology"},{"key":"2026010712112460900_bib22","doi-asserted-by":"publisher","first-page":"155","DOI":"10.3168\/jds.S0022-0302(8082901-8","article-title":"Accuracy of predicting stages of bovine estrous cycle by gross appearance of the corpus luteum","volume":"63","author":"Ireland","year":"1980","journal-title":"Journal of Dairy Science"},{"key":"2026010712112460900_bib23","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1530\/jrf.0.0900279","article-title":"Morphology and proportion of inner cell mass of bovine blastocysts fertilized in vitro and in vivo","volume":"90","author":"Iwasaki","year":"1990","journal-title":"Journal of Reproduction and Fertility"},{"key":"2026010712112460900_bib24","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.21451\/1984-3143-AR987","article-title":"Leptin and IGF-I improve bovine embryo quality in vitro","volume":"14","author":"Kaya","year":"2017","journal-title":"Animal Reproduction"},{"key":"2026010712112460900_bib25","doi-asserted-by":"publisher","first-page":"811","DOI":"10.2527\/jas1982.544811x","article-title":"Observations on the development of bovine morulae on various cellular and noncellular substrata","volume":"54","author":"Kuzan","year":"1982","journal-title":"Journal of Animal Science"},{"key":"2026010712112460900_bib26","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.theriogenology.2022.02.016","article-title":"Impact of uterine epithelial cells and its conditioned medium on the in vitro embryo production in buffalo (Bubalus bubalis)","volume":"183","author":"Lakshmi Devi","year":"2022","journal-title":"Theriogenology"},{"key":"2026010712112460900_bib27","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s40104-022-00763-7","article-title":"Extracellular vesicles from oviductal and uterine fluids supplementation in sequential in vitro culture improves bovine embryo quality","volume":"13","author":"Leal","year":"2022","journal-title":"Journal of Animal Science and Biotechnology"},{"key":"2026010712112460900_bib28","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1080\/14647270600636467","article-title":"Gamete\/embryo - oviduct interactions: implications on in vitro culture","volume":"9","author":"Lee","year":"2006","journal-title":"Human Fertility"},{"key":"2026010712112460900_bib30","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.theriogenology.2007.09.007","article-title":"In vitro-produced bovine embryos: dealing with the warts","volume":"69","author":"Lonergan","year":"2008","journal-title":"Theriogenology"},{"key":"2026010712112460900_bib29","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1530\/jrf.0.1170159","article-title":"Effect of time interval from insemination to first cleavage on the developmental characteristics, sex ratio and pregnancy rate after transfer of bovine embryos","volume":"117","author":"Lonergan","year":"1999","journal-title":"Journal of Reproduction and Fertility"},{"key":"2026010712112460900_bib31","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1046\/j.1439-0531.2003.00437.x","article-title":"Oocyte and embryo quality: effect of origin, culture conditions and gene expression patterns","volume":"38","author":"Lonergan","year":"2003","journal-title":"Reproduction in Domestic Animals"},{"key":"2026010712112460900_bib32","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1071\/RD15238","article-title":"Effect of bovine oviductal fluid on development and quality of bovine embryos produced in vitro","volume":"29","author":"Lopera-Vasquez","year":"2017","journal-title":"Reproduction, Fertility, and Development"},{"key":"2026010712112460900_bib33","doi-asserted-by":"publisher","first-page":"5687","DOI":"10.1073\/pnas.0812722106","article-title":"Endometrium as an early sensor of in vitro embryo manipulation technologies","volume":"106","author":"Mansouri-Attia","year":"2009","journal-title":"PNAS"},{"key":"2026010712112460900_bib34","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1051\/rnd:19890505","article-title":"In vitro culture of bovine egg fertilized either in vivo or in vitro","volume":"29","author":"Marquant-Le Guienne","year":"1989","journal-title":"Reproduction, Nutrition, Development"},{"key":"2026010712112460900_bib35","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/biolre\/ioy199","article-title":"Interferon tau-dependent and independent effects of the bovine conceptus on the endometrial transcriptome\u2020","volume":"100","author":"Mathew","year":"2019","journal-title":"Biology of Reproduction"},{"key":"2026010712112460900_bib36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/jas\/skac123","article-title":"Ruminant conceptus-maternal interactions: interferon-tau and beyond","volume":"100","author":"Mathew","year":"2022","journal-title":"Journal of Animal Science"},{"key":"2026010712112460900_bib37","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/s0093-691x(9700277-x","article-title":"Stimulation of the development of bovine embryos by insulin and insulin-like growth factor-I (IGF-I) is mediated through the IGF-I receptor","volume":"48","author":"Matsui","year":"1997","journal-title":"Theriogenology"},{"key":"2026010712112460900_bib38","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1095\/biolreprod49.3.582","article-title":"Characterization of the embryotrophic activity of exogenous protein-free oviduct-conditioned medium used in culture of cattle Embryos1","volume":"49","author":"Mermillod","year":"1993","journal-title":"Biology of Reproduction"},{"key":"2026010712112460900_bib39","doi-asserted-by":"publisher","first-page":"107264","DOI":"10.1016\/j.anireprosci.2023.107264","article-title":"Progesterone-stimulated endometrial cell conditioned media increases in vitro produced bovine embryo blastocyst formation","volume":"254","author":"Oliver","year":"2023","journal-title":"Animal Reproduction Science"},{"key":"2026010712112460900_bib40","doi-asserted-by":"publisher","DOI":"10.3390\/ani13010098","article-title":"Gene expression of aquaporins (AQPs) in cumulus oocytes complex and embryo of cattle","volume":"13","author":"Petano-Duque","year":"2022","journal-title":"Animals"},{"key":"2026010712112460900_bib41","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1530\/rep.0.1230859","article-title":"Expression of the insulin-like growth factor (IGF) system in the bovine oviduct at oestrus and during early pregnancy","volume":"123","author":"Pushpakumara","year":"2002","journal-title":"Reproduction"},{"key":"2026010712112460900_bib42","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1071\/rd9920547","article-title":"Developmentally related changes in the uptake and metabolism of glucose, glutamine and pyruvate by cattle embryos produced in vitro","volume":"4","author":"Rieger","year":"1992","journal-title":"Reproduction, Fertility, and Development"},{"key":"2026010712112460900_bib43","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1530\/REP-11-0032","article-title":"Disparate consequences of heat stress exposure during meiotic maturation: embryo development after chemical activation vs fertilization of bovine oocytes","volume":"142","author":"Rispoli","year":"2011","journal-title":"Reproduction"},{"key":"2026010712112460900_bib44","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1002\/mrd.1153","article-title":"Consequences of bovine oocyte maturation, fertilization or early embryo development in vitro versus in vivo: implications for blastocyst yield and blastocyst quality","volume":"61","author":"Rizos","year":"2002","journal-title":"Molecular Reproduction and Development"},{"issue":"Supplement 4","key":"2026010712112460900_bib45","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1111\/j.1439-0531.2008.01230.x","article-title":"Consequences of in vitro culture conditions on embryo development and quality","volume":"43","author":"Rizos","year":"2008","journal-title":"Reproduction in Domestic Animals"},{"key":"2026010712112460900_bib46","doi-asserted-by":"publisher","first-page":"4297","DOI":"10.3168\/jds.2007-0002","article-title":"Early in vitro fertilization improves development of bovine ova heat stressed during in vitro maturation","volume":"90","author":"Schrock","year":"2007","journal-title":"Journal of Dairy Science"},{"key":"2026010712112460900_bib47","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1530\/REP-20-0344","article-title":"Molecular interactions at the bovine embryo\u2013endometrial epithelium interface","volume":"160","author":"Sponchiado","year":"2020","journal-title":"Reproduction"},{"key":"2026010712112460900_bib48","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1071\/rd06101","article-title":"Interactions of spermatozoa with the female reproductive tract: inspiration for assisted reproduction","volume":"19","author":"Suarez","year":"2007","journal-title":"Reproduction, Fertility, and Development"},{"key":"2026010712112460900_bib49","doi-asserted-by":"publisher","first-page":"7850","DOI":"10.1038\/s41598-018-26224-8","article-title":"Oviduct epithelium induces interferon-tau in bovine day-4 embryos, which generates an anti-inflammatory response in immune cells","volume":"8","author":"Talukder","year":"2018","journal-title":"Scientific Reports"},{"key":"2026010712112460900_bib50","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1530\/jrf.0.0830487","article-title":"Zona pellucida resistance to sperm penetration before the completion of human oocyte maturation","volume":"83","author":"Tesar\u00edk","year":"1988","journal-title":"Journal of Reproduction and Fertility"},{"key":"2026010712112460900_bib51","first-page":"18","article-title":"2021 Statistics of embryo production and transfer in domestic farm animals","volume":"40","author":"Viana","year":"2022","journal-title":"Embryo Technology Newsletter"},{"key":"2026010712112460900_bib52","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0093-691x(8590218-3","article-title":"Use of a uterine-cell monolayer culture system for micromanipulated bovine embryos","volume":"24","author":"Voelkel","year":"1985","journal-title":"Theriogenology"},{"key":"2026010712112460900_bib53","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.anireprosci.2008.09.019","article-title":"Expression of IGF receptors and its ligands in bovine oocytes and preimplantation embryos","volume":"114","author":"Wang","year":"2009","journal-title":"Animal Reproduction Science"},{"key":"2026010712112460900_bib54","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s10616-011-9402-5","article-title":"Knockdown of IGF-IR by siRNA injection during bovine preimplantation embryonic development","volume":"64","author":"Wang","year":"2012","journal-title":"Cytotechnology"},{"key":"2026010712112460900_bib55","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1530\/REP-19-0286","article-title":"Interleukin-6 requires JAK to stimulate inner cell mass expansion in bovine embryos","volume":"158","author":"Wooldridge","year":"2019","journal-title":"Reproduction"},{"key":"2026010712112460900_bib56","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1071\/RD15226","article-title":"Combinatorial effects of epidermal growth factor, fibroblast growth factor 2 and insulin-like growth factor 1 on trophoblast cell proliferation and embryogenesis in cattle","volume":"29","author":"Xie","year":"2017","journal-title":"Reproduction, Fertility, and Development"}],"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rep.bioscientifica.com\/view\/journals\/rep\/167\/5\/REP-24-0008.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rep.bioscientifica.com\/downloadpdf\/journals\/rep\/167\/5\/REP-24-0008.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/167\/5\/e240008\/64910931\/rep-24-0008.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/167\/5\/e240008\/64910931\/rep-24-0008.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T17:11:31Z","timestamp":1767805891000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/doi\/10.1530\/REP-24-0008\/8217351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,17]]},"references-count":56,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5,1]]}},"URL":"https:\/\/doi.org\/10.1530\/rep-24-0008","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,4,17]]},"published":{"date-parts":[[2024,4,17]]},"article-number":"e240008"}}