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This study shows that myricetin potently improves PCOS by activating brown adipose tissue (BAT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>PCOS is a complex endocrine disease characterized by hyperandrogenism, anovulation and polycystic ovary, and is often accompanied by metabolic disorder such as insulin resistance. BAT has been considered as a promising target for the treatment of obesity and other metabolic disease. In this study, we showed that 3 weeks of myricetin (a compound from natural product) treatment improved metabolic capacity and insulin sensitivity by activating BAT in dehydroepiandrosterone (DHEA)-induced PCOS mice. Furthermore, increased number of corpus luteum and decreased cystic formation were observed in PCOS mice. With the hormone levels such as luteinizing hormone (LH) were reversed, estrous cycle was also normalized after myricetin treatment. Eventually, myricetin markedly improved reproductive defects in PCOS mice. In short, our results suggest that myricetin treatment dramatically ameliorates ovarian dysfunction and metabolic disturbances in PCOS and provides a novel perspective for the treatment of PCOS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/rep-24-0034","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T12:30:26Z","timestamp":1711110626000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":15,"title":["Myricetin ameliorates polycystic ovary syndrome in mice by brown adipose tissue activation"],"prefix":"10.1093","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7025-7977","authenticated-orcid":false,"given":"Niuyi","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Anatomy , Basic Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China"},{"name":"Jiangsu Key Laboratory of Immunity and Metabolism , Department of Pathogen Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8220-1567","authenticated-orcid":false,"given":"Chaolong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anatomy , Basic Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China"},{"name":"Jiangsu Key Laboratory of Immunity and Metabolism , Department of Pathogen Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqiu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anatomy , Basic Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China"},{"name":"Jiangsu Key Laboratory of Immunity and Metabolism , Department of Pathogen Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Anatomy , Basic Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China"},{"name":"Jiangsu Key Laboratory of Immunity and Metabolism , Department of Pathogen Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1485-0084","authenticated-orcid":false,"given":"Tao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Anatomy , Basic Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China"},{"name":"Jiangsu Key Laboratory of Immunity and Metabolism , Department of Pathogen Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"key":"2026010712120044300_bib1","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/j.fertnstert.2006.12.055","article-title":"Role of insulin in the hyperandrogenemia of lean women with polycystic ovary syndrome and normal insulin sensitivity","volume":"88","author":"Baillargeon","year":"2007","journal-title":"Fertility and Sterility"},{"key":"2026010712120044300_bib2","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1007\/s43032-020-00279-3","article-title":"Environment, lifestyle, and female infertility","volume":"28","author":"Bala","year":"2021","journal-title":"Reproductive Sciences"},{"key":"2026010712120044300_bib3","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/nrendo.2013.204","article-title":"Adipose tissue browning and metabolic health","volume":"10","author":"Bartelt","year":"2014","journal-title":"Nature Reviews. 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