{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:32:58Z","timestamp":1789410778239,"version":"build-2803163510"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:title>\u2003<\/jats:title>\n                  <jats:sec>\n                    <jats:title>In brief<\/jats:title>\n                    <jats:p>SORBS2, an RNA-binding protein, is identified as a regulator of aerobic glycolysis, which is essential for trophoblast migration and placental development. Reduced SORBS2 expression in preeclampsia may impair trophoblast migration by affecting mRNA stability and glycolysis, suggesting its role in the disease\u2019s pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Insufficient trophoblast migration and impaired uterine spiral artery remodeling are implicated in the pathogenesis of preeclampsia, contributing to inadequate placentation. However, the molecular mechanism underlying this process remains unclear. Aerobic glycolysis, which produces substantial lactate, is crucial for establishing a favorable microenvironment for early uterine preparation and supporting embryo implantation and trophoblast migration. In the present study, we have demonstrated that SORBS2, an RNA-binding protein, regulated aerobic glycolysis and significantly improved trophoblast migration in vitro. Our results showed that SORBS2 expression was significantly reduced in human PE placentas and trophoblasts during hypoxia. Overexpression of SORBS2 enhanced cell proliferation and migration, whereas knockdown of SORBS2 decreased these functions in HTR-8\/SVneo cells. Mechanistic studies have demonstrated that SORBS2 directly interacts with the 3\u2032 untranslated regions (UTRs) of key glycolysis-related genes, specifically HK2. This interaction results in enhanced stability of HK2 and activation of glycolysis. Moreover, silencing HK2 abrogated the enhancement of proliferation and migration of HTR-8\/SVneo cells induced by SORBS2. In conclusion, our findings suggest that the downregulation of SORBS2 may contribute to the pathogenesis of preeclampsia by regulating mRNA stability and inhibiting trophoblast migration during placentation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/rep-24-0093","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T12:38:33Z","timestamp":1720787913000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":7,"title":["RNA-binding protein SORBS2 increases human trophoblast cell migration via stabilizing HK2 mRNA in preeclampsia"],"prefix":"10.1093","volume":"168","author":[{"given":"Limin","family":"Song","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology , The Second Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Hemodialysis , Beidahuang Group General Hospital, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , The Second Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , The Second Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , The Second Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianxiu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , The Second Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijing","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , The Second Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , The Second Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihai","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , The Second Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodan","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , The Second Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0703-488X","authenticated-orcid":false,"given":"Man","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , The Second Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,14]]},"reference":[{"key":"2026010712103204400_bib1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14102172","article-title":"The relationship between angiogenic factors and energy metabolism in preeclampsia","volume":"14","author":"Abascal-Saiz","year":"2022","journal-title":"Nutrients"},{"key":"2026010712103204400_bib2","doi-asserted-by":"publisher","first-page":"2744","DOI":"10.1172\/JCI116515","article-title":"Pre-eclampsia is associated with an increase in trophoblast glycogen content and glycogen synthase activity, similar to that found in hydatidiform moles","volume":"91","author":"Arkwright","year":"1993","journal-title":"Journal of Clinical Investigation"},{"issue":"Supplement","key":"2026010712103204400_bib3","doi-asserted-by":"publisher","first-page":"S32","DOI":"10.1016\/j.placenta.2013.11.013","article-title":"Review: maternal and placental antioxidant response to preeclampsia - impact on vasoactive eicosanoids","volume":"35","author":"Bilodeau","year":"2014","journal-title":"Placenta"},{"key":"2026010712103204400_bib4","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41572-023-00417-6","article-title":"Pre-eclampsia","volume":"9","author":"Dimitriadis","year":"2023","journal-title":"Nature Reviews. 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