{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:02:53Z","timestamp":1792270973744,"version":"4.4.0"},"reference-count":92,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"<jats:title>\u2003<\/jats:title>\n                  <jats:sec>\n                    <jats:title>In brief<\/jats:title>\n                    <jats:p>This review article highlights the associations between endocrine-disrupting chemicals, reproductive aging, and menopause. Collectively, the current literature indicates that phthalates, bisphenols, parabens, per- and poly-fluoroalkyl substances, polychlorinated biphenyls, dioxins, and pesticides are associated with reproductive aging in women and animal models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Menopause marks the end of a woman\u2019s reproductive lifetime and can have a significant effect on a woman\u2019s quality of life. Menopause naturally occurs at 51 years of age on average, but recent literature suggests that endocrine-disrupting chemicals (EDCs) in our environment can accelerate reproductive aging, causing women to reach menopause at earlier ages. This is concerning as menopause can significantly alter a woman\u2019s quality of life and is associated with increased risks of conditions such as depression, osteoporosis, and cardiovascular disease. EDC exposures have also been associated with more intense menopausal symptoms, making the menopausal transition more difficult for some women. This review highlights the associations between EDC exposure, early menopause, and reproductive aging, using both epidemiological and experimental studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/rep-24-0113","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T13:55:10Z","timestamp":1725285310000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":15,"title":["Impact of Real-life Environmental Exposures on Reproduction: Endocrine-disrupting chemicals, reproductive aging, and menopause"],"prefix":"10.1093","volume":"168","author":[{"given":"Zane Cutright","family":"Inman","sequence":"first","affiliation":[{"name":"Department of Comparative Biosciences , College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5579-9268","authenticated-orcid":false,"given":"Jodi A","family":"Flaws","sequence":"additional","affiliation":[{"name":"Department of Comparative Biosciences , College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"2026010712102584800_bib2","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1080\/15287390490483845","article-title":"Age at natural menopause and exposure to organochlorine pesticides in Hispanic women","volume":"67","author":"Akkina","year":"2004","journal-title":"Journal of Toxicology and Environmental Health. 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