{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:01:57Z","timestamp":1791846117307,"version":"4.3.4"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013072","name":"Major Science and Technology project of Hainan Province","doi-asserted-by":"crossref","award":["ZDKJ2021037"],"award-info":[{"award-number":["ZDKJ2021037"]}],"id":[{"id":"10.13039\/501100013072","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82201874, 81960283"],"award-info":[{"award-number":["82201874, 81960283"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hainan Province","doi-asserted-by":"crossref","award":["822MS175"],"award-info":[{"award-number":["822MS175"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013142","name":"Key Research and Development Project of Hainan Province","doi-asserted-by":"crossref","award":["ZDYF2022SHFZ311"],"award-info":[{"award-number":["ZDYF2022SHFZ311"]}],"id":[{"id":"10.13039\/501100013142","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7,15]]},"abstract":"<jats:sec>\n                    <jats:title>In brief<\/jats:title>\n                    <jats:p>Preeclampsia is a severe pregnancy-related complication that can result in adverse maternal and fetal outcomes. Current therapeutic options for preeclampsia remain limited. This study demonstrates that epicatechin can inhibit pyroptosis in extravillous trophoblasts and block the activation of the NF-\u03baB signaling pathway, thereby offering a novel therapeutic approach for the management of preeclampsia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Preeclampsia (PE) is characterized as new-onset hypertension and proteinuria after 20 weeks of gestation, and affects 5\u20137% pregnant women globally. PE is associated with a systemic inflammatory status that is overly activated and contributes to dysregulated extravillous trophoblasts (EVTs) invasion and impaired spiral vessel remodeling. Recent studies showed that inhibition of systematic inflammatory response significantly ameliorates the PE-like symptoms, suggesting that anti-inflammation could be a potential PE treatment. However, few effective therapeutic strategies have been shown to control systemic inflammation in PE patients. In the current study, we investigated the protective effects of epicatechin (EC), a small molecule compound that exhibits excellent anti-inflammatory activity on HTR8\/SVneo cells and EVTs stimulated with lipopolysaccharide (LPS). Our results revealed that EC pretreatment significantly improved cellular viability and attenuated the inflammatory response of EVTs in response to LPS stimulation. Mechanistically, we found that EC significantly blocked the activation of the LPS-induced pyroptosis pathway of classical pyrin domain protein 3, cleaved caspase 1 and cleaved gasdermin D (NLRP3\/caspase-1\/GSDMD) in LPS-treated EVTs and inhibited interleukin-1\u03b2 (IL-1\u03b2) expression (a hallmark of pyroptosis) by suppressing the nuclear factor-\u03baB (NF-\u03baB) signaling. Our study demonstrates the protective effects of EC on LPS-stimulated inflammation and provides the direct evidence\n                      <jats:italic>in vitro<\/jats:italic>\n                      that EC may be a promising compound that mitigates the PE-associated systemic inflammation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/rep-24-0182","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T15:44:03Z","timestamp":1752594243000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":2,"title":["Epicatechin inhibits inflammatory injury in preeclampsia extravillous trophoblasts"],"prefix":"10.1093","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9144-6773","authenticated-orcid":true,"given":"Mengyongwei","family":"Li","sequence":"first","affiliation":[{"name":"Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, Hainan Provincial Clinical Research Center for Thalassemia, Department of Reproductive Medicine, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, Hainan, China"},{"name":"Key Laboratory of Reproductive Health Diseases Research and Translation (Hainan Medical University), Ministry of Education, Haikou, Hainan, China"},{"name":"Haikou Key Laboratory for Preservation of Human Genetic Resource, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6836-0016","authenticated-orcid":true,"given":"Mian","family":"Liu","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, Hainan Provincial Clinical Research Center for Thalassemia, Department of Reproductive Medicine, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, Hainan, China"},{"name":"Key Laboratory of Reproductive Health Diseases Research and Translation (Hainan Medical University), Ministry of Education, Haikou, Hainan, China"},{"name":"Haikou Key Laboratory for Preservation of Human Genetic Resource, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, Hainan, China"},{"name":"Department of Obstetrics and Gynecology, Reproductive Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7391-4049","authenticated-orcid":true,"given":"Jiaoqi","family":"Mei","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, Hainan Provincial Clinical Research Center for Thalassemia, Department of Reproductive Medicine, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, Hainan, China"},{"name":"Key Laboratory of Reproductive Health Diseases Research and Translation (Hainan Medical University), Ministry of Education, Haikou, Hainan, China"},{"name":"Haikou Key Laboratory for Preservation of Human Genetic Resource, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5422-8137","authenticated-orcid":true,"given":"Haofu","family":"Dai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Products Research and Development From Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7028-7858","authenticated-orcid":true,"given":"Huiqin","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Products Research and Development From Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1338-0888","authenticated-orcid":true,"given":"Qiuling","family":"Jie","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, Hainan Provincial Clinical Research Center for Thalassemia, Department of Reproductive Medicine, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, Hainan, China"},{"name":"Key Laboratory of Reproductive Health Diseases Research and Translation (Hainan Medical University), Ministry of Education, Haikou, Hainan, China"},{"name":"Haikou Key Laboratory for Preservation of Human Genetic Resource, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1483-2246","authenticated-orcid":true,"given":"Jingjing","family":"Mei","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, Hainan Provincial Clinical Research Center for Thalassemia, Department of Reproductive Medicine, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, Hainan, China"},{"name":"Key Laboratory of Reproductive Health Diseases Research and Translation (Hainan Medical University), Ministry of Education, Haikou, Hainan, China"},{"name":"Haikou Key Laboratory for Preservation of Human Genetic Resource, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2937-2276","authenticated-orcid":true,"given":"Xiaohui","family":"Yang","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, Hainan Provincial Clinical Research Center for Thalassemia, Department of Reproductive Medicine, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, Hainan, China"},{"name":"Key Laboratory of Reproductive Health Diseases Research and Translation (Hainan Medical University), Ministry of Education, Haikou, Hainan, China"},{"name":"Haikou Key Laboratory for Preservation of Human Genetic Resource, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7698-6309","authenticated-orcid":true,"given":"Jinyu","family":"Kang","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, Hainan Provincial Clinical Research Center for Thalassemia, Department of Reproductive Medicine, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, Hainan, China"},{"name":"Key Laboratory of Reproductive Health Diseases Research and Translation (Hainan Medical University), Ministry of Education, Haikou, Hainan, China"},{"name":"Haikou Key Laboratory for Preservation of Human Genetic Resource, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9668-0204","authenticated-orcid":true,"given":"Yanlin","family":"Ma","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, Hainan Provincial Clinical Research Center for Thalassemia, Department of Reproductive Medicine, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, Hainan, China"},{"name":"Key Laboratory of Reproductive Health Diseases Research and Translation (Hainan Medical University), Ministry of Education, Haikou, Hainan, China"},{"name":"Haikou Key Laboratory for Preservation of Human Genetic Resource, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4076-3497","authenticated-orcid":true,"given":"Wenli","family":"Mei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Products Research and Development From Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"bib1","series-title":"Food Funct","first-page":"8811","article-title":"(\u2212)-Epicatechin and the colonic metabolite 2,3-dihydroxybenzoic acid protect against high glucose and lipopolysaccharide-induced inflammation in renal proximal tubular cells through NOX-4\/p38 signalling","volume":"11","author":"\u00c1lvarez Cilleros D","year":"2020","unstructured":"\u00c1lvarez Cilleros D\n, \nL\u00f3pez-Oliva ME\n, \nMart\u00edn M\n, et al.\n 2020 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