{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T07:24:11Z","timestamp":1783754651874,"version":"3.55.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10,30]]},"abstract":"<jats:sec>\n                    <jats:title>In brief<\/jats:title>\n                    <jats:p>The brain-derived neurotrophic factor (BDNF) has been shown to regulate metabolism in zebrafish. This research shows that Bdnf is a regulator of female zebrafish reproduction and reproductive hormones.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      BDNF is a peptide widely known for its role in neurogenesis and synaptic plasticity. Its expression in non-neuronal tissues has been reported. In mammals, it is involved in ovarian development, follicle growth, oocyte maturation and early embryonic development. In zebrafish, it was demonstrated that Bdnf increases food intake and regulates metabolism. Reproduction and metabolism are tightly linked. We hypothesized that Bdnf modulates reproductive hormones and reproductive functions in zebrafish. This study aimed to determine Bdnf expression in the zebrafish reproductive axis and whether it modulates the reproductive endocrine milieu and oocyte biology in zebrafish. Our results show that\n                      <jats:italic>bdnf<\/jats:italic>\n                      and its receptor\n                      <jats:italic>trkb<\/jats:italic>\n                      and Bdnf-like immunoreactivity are present in zebrafish gonads and liver cells. This suggests Bdnf local production and possible actions within the gonads and liver. Intraperitoneal administration of 1, 10 or 100 ng\/g body weight BDNF significantly (ANOVA,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05) increased\n                      <jats:italic>sgnrh<\/jats:italic>\n                      \/\n                      <jats:italic>cgnrh-II<\/jats:italic>\n                      ,\n                      <jats:italic>kiss1<\/jats:italic>\n                      and\n                      <jats:italic>cyp19a1b<\/jats:italic>\n                      mRNAs in the zebrafish brain, steroidogenic enzymes (\n                      <jats:italic>star<\/jats:italic>\n                      and\n                      <jats:italic>cyp19a1a<\/jats:italic>\n                      ) and key receptors in the zebrafish gonads.\n                      <jats:italic>In vitro<\/jats:italic>\n                      incubation of zebrafish liver cells with BDNF significantly (ANOVA,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05) increased estrogen receptor mRNAs and vitellogenin concentrations (ELISA) in the cells. BDNF (100 ng\/mL) induced (ANOVA,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05) oocyte maturation\n                      <jats:italic>in vitro<\/jats:italic>\n                      at 24 h post-incubation and significantly upregulated cumulus-expansion-related genes (ANOVA,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05). Overall, our findings indicate a stimulatory role for Bdnf in the reproductive axis of zebrafish. This provides impetus for future research on its mechanism of action and potential practical applications to enhance reproduction in aquaculture.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/rep-24-0233","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T14:27:41Z","timestamp":1730298461000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":4,"title":["Brain-derived neurotrophic factor stimulates hypothalamic and gonadal reproductive hormones and oocyte maturation in zebrafish"],"prefix":"10.1093","volume":"169","author":[{"given":"Chinelo","family":"Uju","sequence":"first","affiliation":[{"name":"Laboratory of Integrative Neuroendocrinology, Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katayoon","family":"Karimzadeh","sequence":"additional","affiliation":[{"name":"Laboratory of Integrative Neuroendocrinology, Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada"},{"name":"Marine Biology Department, Islamic Azad University, Lahijan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2002-9893","authenticated-orcid":true,"given":"Suraj","family":"Unniappan","sequence":"additional","affiliation":[{"name":"Laboratory of Integrative Neuroendocrinology, Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"bib1","series-title":"J Neurosci Res","first-page":"525","article-title":"Mouse and ratBDNF gene structure and expression revisited","volume":"85","author":"Aid T","year":"2007","unstructured":"Aid T, Kazantseva A, Piirsoo M, et al. 2007 Mouse and ratBDNF gene structure and expression revisited. J Neurosci Res 85 525\u2013535. (https:\/\/doi.org\/10.1002\/jnr.21139)"},{"key":"bib2","series-title":"Nat Metab","first-page":"627","article-title":"Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis","volume":"4","author":"Ameroso D","year":"2022","unstructured":"Ameroso D, Meng A, Chen S, et al. 2022 Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis. Nat Metab 4 627\u2013643. (https:\/\/doi.org\/10.1038\/s42255-022-00566-0)"},{"key":"bib3","series-title":"Fertil Steril","first-page":"1394","article-title":"Brain-derived neurotrophic factor is a regulator of human oocyte maturation and early embryo development","volume":"93","author":"Anderson RA","year":"2010","unstructured":"Anderson RA, Bayne RAL, Gardner J, et al. 2010 Brain-derived neurotrophic factor is a regulator of human oocyte maturation and early embryo development. Fertil Steril 93 1394\u20131406. (https:\/\/doi.org\/10.1016\/j.fertnstert.2009.04.007)"},{"key":"bib4","series-title":"Int J Mol Sci","first-page":"2621","article-title":"The BDNF\/TrkB neurotrophin system in the sensory organs of zebrafish","volume":"23","author":"Aragona M","year":"2022","unstructured":"Aragona M, Porcino C, Guerrera MC, et al. 2022 The BDNF\/TrkB neurotrophin system in the sensory organs of zebrafish. Int J Mol Sci 23 2621. (https:\/\/doi.org\/10.3390\/ijms23052621)"},{"key":"bib5","series-title":"Androgens: Clin Res Ther","first-page":"189","article-title":"Aromatase in the human brain","volume":"2","author":"Azcoitia I","year":"2021","unstructured":"Azcoitia I, Mendez P & Garcia-Segura LM 2021 Aromatase in the human brain. Androgens: Clin Res Ther 2 189\u2013202. (https:\/\/doi.org\/10.1089\/andro.2021.0007)"},{"key":"bib6","series-title":"Sci Rep","first-page":"10727","article-title":"Feeding and food availability modulate brain-derived neurotrophic factor, an orexigen with metabolic roles in zebrafish","volume":"10","author":"Blanco AM","year":"2020","unstructured":"Blanco AM, Bertucci JI, Hatef A, et al. 2020 Feeding and food availability modulate brain-derived neurotrophic factor, an orexigen with metabolic roles in zebrafish. Sci Rep 10 10727. (https:\/\/doi.org\/10.1038\/s41598-020-67535-z)"},{"key":"bib7","series-title":"Biology and Physiology of Freshwater Neotropical Fish","first-page":"315","article-title":"The brain\u2013pituitary\u2013gonad axis and the gametogenesis","author":"Borella MI","year":"2020","unstructured":"Borella MI, Chehade C, Costa FG, et al. 2020 The brain\u2013pituitary\u2013gonad axis and the gametogenesis. In Biology and Physiology of Freshwater Neotropical Fish, B Baldisserotto, E C Urbinati, JEP Cyrino (eds). pp 315\u2013341. Elsevier. (https:\/\/doi.org\/10.1016\/B978-0-12-815872-2.00014-2)"},{"key":"bib9","series-title":"PLoS One","first-page":"e0158057","article-title":"BDNF expression in larval and adult zebrafish brain: distribution and cell identification","volume":"11","author":"Cacialli P","year":"2016","unstructured":"Cacialli P, Gueguen M-M, Coumailleau P, et al. 2016 BDNF expression in larval and adult zebrafish brain: distribution and cell identification. PLoS One 11 e0158057. (https:\/\/doi.org\/10.1371\/journal.pone.0158057)"},{"key":"bib8","series-title":"Anat Rec","first-page":"140","article-title":"Morpho-functional features of the gonads of Danio rerio: the role of brain-derived neurotrophic factor: BDNF in the gonads of zebrafish","volume":"301","author":"Cacialli P","year":"2018","unstructured":"Cacialli P, D\u2019Angelo L, de Girolamo P, et al. 2018 Morpho-functional features of the gonads of Danio rerio: the role of brain-derived neurotrophic factor: BDNF in the gonads of zebrafish. Anat Rec 301 140\u2013147. (https:\/\/doi.org\/10.1002\/ar.23702)"},{"key":"bib10","series-title":"Hum Reprod Update","first-page":"545","article-title":"Brain-derived neurotrophic factor (BDNF) expression and function in the mammalian reproductive tract","volume":"26","author":"Chow R","year":"2020","unstructured":"Chow R, Wessels JM & Foster WG 2020 Brain-derived neurotrophic factor (BDNF) expression and function in the mammalian reproductive tract. Hum Reprod Update 26 545\u2013564. (https:\/\/doi.org\/10.1093\/humupd\/dmaa008)"},{"key":"bib11","series-title":"Mol Cell Endocrinol","first-page":"42","article-title":"Endocrine\/paracrine control of zebrafish ovarian development","volume":"312","author":"Clelland E","year":"2009","unstructured":"Clelland E & Peng C 2009 Endocrine\/paracrine control of zebrafish ovarian development. Mol Cell Endocrinol 312 42\u201352. (https:\/\/doi.org\/10.1016\/j.mce.2009.04.009)"},{"key":"bib12","series-title":"BioRxiv","article-title":"Cholecystokinin gates reproduction in zebrafish by controlling gonadotropin secretion","author":"Cohen LH","year":"2023","unstructured":"Cohen LH, Cohen O, Shulman M, et al. 2023 Cholecystokinin gates reproduction in zebrafish by controlling gonadotropin secretion. BioRxiv. (https:\/\/doi.org\/10.1101\/2023.06.18.545454)"},{"key":"bib13","series-title":"Int J Mol Sci","first-page":"7777","article-title":"Neurotrophic factor BDNF, physiological functions and therapeutic potential in depression, neurodegeneration and brain cancer","volume":"21","author":"Colucci-D\u2019Amato L","year":"2020","unstructured":"Colucci-D\u2019Amato L, Speranza L & Volpicelli F 2020 Neurotrophic factor BDNF, physiological functions and therapeutic potential in depression, neurodegeneration and brain cancer. Int J Mol Sci 21 7777. (https:\/\/doi.org\/10.3390\/ijms21207777)"},{"key":"bib14","series-title":"Eur J Neurosci","first-page":"338","article-title":"Neurotrophic effects of BDNF on embryonic gonadotropin\u2010releasing hormone (GnRH) neurons","volume":"20","author":"Cronin AS","year":"2004","unstructured":"Cronin AS, Horan TL, Spergel DJ, et al. 2004 Neurotrophic effects of BDNF on embryonic gonadotropin\u2010releasing hormone (GnRH) neurons. Eur J Neurosci 20 338\u2013344. (https:\/\/doi.org\/10.1111\/j.1460-9568.2004.03490.x)"},{"key":"bib15","series-title":"Endocrinology","first-page":"980","article-title":"Nuclear androgen receptor regulates testes organization and oocyte maturation in zebrafish","volume":"159","author":"Crowder CM","year":"2018","unstructured":"Crowder CM, Lassiter CS & Gorelick DA 2018 Nuclear androgen receptor regulates testes organization and oocyte maturation in zebrafish. Endocrinology 159 980\u2013993. (https:\/\/doi.org\/10.1210\/en.2017-00617)"},{"key":"bib16","series-title":"iScience","first-page":"104054","article-title":"Loss of circadian rhythmicity in bdnf knockout zebrafish larvae","volume":"25","author":"D\u2019Agostino Y","year":"2022","unstructured":"D\u2019Agostino Y, Frigato E, Noviello TMR, et al. 2022 Loss of circadian rhythmicity in bdnf knockout zebrafish larvae. iScience 25 104054. (https:\/\/doi.org\/10.1016\/j.isci.2022.104054)"},{"key":"bib17","series-title":"J Comp Neurol","first-page":"1004","article-title":"Brain\u2010derived neurotrophic factor: mRNA expression and protein distribution in the brain of the teleost Nothobranchius furzeri","volume":"522","author":"D\u2019Angelo L","year":"2014","unstructured":"D\u2019Angelo L, De Girolamo P, Lucini C, et al. 2014 Brain\u2010derived neurotrophic factor: mRNA expression and protein distribution in the brain of the teleost Nothobranchius furzeri. J Comp Neurol 522 1004\u20131030. (https:\/\/doi.org\/10.1002\/cne.23457)"},{"key":"bib18","series-title":"Endocrinology","first-page":"5005","article-title":"Neurotrophins acting via TRKB receptors activate the JAGGED1-NOTCH2 cell\u2013cell communication pathway to facilitate early ovarian development","volume":"152","author":"Dorfman MD","year":"2011","unstructured":"Dorfman MD, Kerr B, Garcia-Rudaz C, et al. 2011 Neurotrophins acting via TRKB receptors activate the JAGGED1-NOTCH2 cell\u2013cell communication pathway to facilitate early ovarian development. Endocrinology 152 5005\u20135016. (https:\/\/doi.org\/10.1210\/en.2011-1465)"},{"key":"bib19","series-title":"Ann Anat - Anatomischer Anzeiger","first-page":"192","article-title":"Brain derived neurotrophic factor in the retina of the teleost N. furzeri","volume":"196","author":"Gatta C","year":"2014","unstructured":"Gatta C, Castaldo L, Cellerino A, et al. 2014 Brain derived neurotrophic factor in the retina of the teleost N. furzeri. Ann Anat - Anatomischer Anzeiger 196 192\u2013196. (https:\/\/doi.org\/10.1016\/j.aanat.2014.01.002)"},{"key":"bib20","series-title":"Endocrinology","first-page":"4158","article-title":"Morpholino-mediated knockdown of ER\u03b1, ER\u03b2a, and ER\u03b2b mRNAs in zebrafish (Danio rerio) embryos reveals differential regulation of estrogen-inducible genes","volume":"154","author":"Griffin LB","year":"2013","unstructured":"Griffin LB, January KE, Ho KW, et al. 2013 Morpholino-mediated knockdown of ER\u03b1, ER\u03b2a, and ER\u03b2b mRNAs in zebrafish (Danio rerio) embryos reveals differential regulation of estrogen-inducible genes. Endocrinology 154 4158\u20134169. (https:\/\/doi.org\/10.1210\/en.2013-1446)"},{"key":"bib21","series-title":"Trans Am Clin Climatol Assoc","first-page":"9","article-title":"Brain-derived neurotrophic factor: three ligands, many actions","volume":"126","author":"Hempstead BL","year":"2015","unstructured":"Hempstead BL 2015 Brain-derived neurotrophic factor: three ligands, many actions. Trans Am Clin Climatol Assoc 126 9\u201319."},{"key":"bib23","series-title":"J Exp Biol","first-page":"2087","article-title":"Expression and function of brain-derived neurotrophin factor and its receptor, TrkB, in ovarian follicles from the domestic hen (Gallus gallus domesticus)","volume":"204","author":"Jensen T","year":"2001","unstructured":"Jensen T & Johnson AL 2001 Expression and function of brain-derived neurotrophin factor and its receptor, TrkB, in ovarian follicles from the domestic hen (Gallus gallus domesticus). J Exp Biol 204 2087\u20132095. (https:\/\/doi.org\/10.1242\/jeb.204.12.2087)"},{"key":"bib24","series-title":"Handbook of Hormones","first-page":"471","article-title":"Neurotrophin family","author":"Kakizawa S","year":"2021","unstructured":"Kakizawa S 2021 Neurotrophin family. In Handbook of Hormones, H Ando, K Ukena, S Nagata (eds). pp 471\u2013473. Elsevier. (https:\/\/doi.org\/10.1016\/B978-0-12-820649-2.00120-0)"},{"key":"bib25","series-title":"Proc Natl Acad Sci","first-page":"9206","article-title":"Ovarian brain-derived neurotrophic factor (BDNF) promotes the development of oocytes into preimplantation embryos","volume":"102","author":"Kawamura K","year":"2005","unstructured":"Kawamura K, Kawamura N, Mulders SM, et al. 2005 Ovarian brain-derived neurotrophic factor (BDNF) promotes the development of oocytes into preimplantation embryos. Proc Natl Acad Sci 102 9206\u20139211. (https:\/\/doi.org\/10.1073\/pnas.0502442102)"},{"key":"bib26","series-title":"Reproduction","first-page":"131","article-title":"NTRK1 and NTRK2 receptors facilitate follicle assembly and early follicular development in the mouse ovary","volume":"138","author":"Kerr B","year":"2009","unstructured":"Kerr B, Garcia-Rudaz C, Dorfman M, et al. 2009 NTRK1 and NTRK2 receptors facilitate follicle assembly and early follicular development in the mouse ovary. Reproduction 138 131\u2013140. (https:\/\/doi.org\/10.1530\/REP-08-0474)"},{"key":"bib27","series-title":"Reproduction","first-page":"405","article-title":"Beneficial effects of brain-derived neurotropic factor on in vitro maturation of porcine oocytes","volume":"134","author":"Lee E","year":"2007","unstructured":"Lee E, Jeong YI, Park SM, et al. 2007 Beneficial effects of brain-derived neurotropic factor on in vitro maturation of porcine oocytes. Reproduction 134 405\u2013414. (https:\/\/doi.org\/10.1530\/REP-06-0288)"},{"key":"bib28","series-title":"Methods","first-page":"402","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak KJ","year":"2001","unstructured":"Livak KJ & Schmittgen TD 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method. Methods 25 402\u2013408. (https:\/\/doi.org\/10.1006\/meth.2001.1262)"},{"key":"bib29","series-title":"Int J Mol Sci","first-page":"3155","article-title":"BDNF, brain, and regeneration: insights from zebrafish","volume":"19","author":"Lucini C","year":"2018","unstructured":"Lucini C, D\u2019Angelo L, Cacialli P, et al. 2018 BDNF, brain, and regeneration: insights from zebrafish. Int J Mol Sci 19 3155. (https:\/\/doi.org\/10.3390\/ijms19103155)"},{"key":"bib30","series-title":"Endocrine","first-page":"7","article-title":"Role of the steroidogenic acute regulatory protein in health and disease","volume":"51","author":"Manna PR","year":"2016","unstructured":"Manna PR, Stetson CL, Slominski AT, et al. 2016 Role of the steroidogenic acute regulatory protein in health and disease. Endocrine 51 7\u201321. (https:\/\/doi.org\/10.1007\/s12020-015-0715-6)"},{"key":"bib31","series-title":"Diabetologia","first-page":"1409","article-title":"Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase","volume":"52","author":"Matthews VB","year":"2009","unstructured":"Matthews VB, \u00c5str\u00f6m M-B, Chan MHS, et al. 2009 Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase. Diabetologia 52 1409\u20131418. (https:\/\/doi.org\/10.1007\/s00125-009-1364-1)"},{"key":"bib32","series-title":"Scientific Rep","first-page":"16442","article-title":"Lower brain-derived neurotrophic factor levels are associated with age-related memory impairment in community-dwelling older adults: the Sefuri study","volume":"10","author":"Mizoguchi Y","year":"2020","unstructured":"Mizoguchi Y, Yao H, Imamura Y, et al. 2020 Lower brain-derived neurotrophic factor levels are associated with age-related memory impairment in community-dwelling older adults: the Sefuri study. Scientific Rep 10 16442. (https:\/\/doi.org\/10.1038\/s41598-020-73576-1)"},{"key":"bib33","series-title":"Dev Growth and Differ","first-page":"S195","article-title":"Regulation of oocyte maturation in fish: regulation of oocyte maturation in fish","volume":"50","author":"Nagahama Y","year":"2008","unstructured":"Nagahama Y & Yamashita M 2008 Regulation of oocyte maturation in fish: regulation of oocyte maturation in fish. Dev Growth and Differ 50 S195\u2013S219. (https:\/\/doi.org\/10.1111\/j.1440-169X.2008.01019.x)"},{"key":"bib34","series-title":"Andrologia","first-page":"e12601","article-title":"Effect of brain-derived neurotrophic factor on sperm function, oxidative stress and membrane integrity in human","volume":"49","author":"Najafi A","year":"2017","unstructured":"Najafi A, Amidi F, Sedighi Gilani MA, et al. 2017 Effect of brain-derived neurotrophic factor on sperm function, oxidative stress and membrane integrity in human. Andrologia 49 e12601. (https:\/\/doi.org\/10.1111\/and.12601)"},{"key":"bib35","series-title":"Mol Cell Endocrinol","first-page":"111401","article-title":"Nucleobindin-derived nesfatin-1 and nesfatin-1-like peptide stimulate pro-opiomelanocortin synthesis in murine AtT-20 corticotrophs through the cAMP\/PKA\/CREB signaling pathway","volume":"536","author":"Nasri A","year":"2021","unstructured":"Nasri A & Unniappan S 2021 Nucleobindin-derived nesfatin-1 and nesfatin-1-like peptide stimulate pro-opiomelanocortin synthesis in murine AtT-20 corticotrophs through the cAMP\/PKA\/CREB signaling pathway. Mol Cell Endocrinol 536 111401. (https:\/\/doi.org\/10.1016\/j.mce.2021.111401)"},{"key":"bib36","series-title":"Endocrinology","first-page":"1668","article-title":"Functional significance of nuclear estrogen receptor subtypes in the liver of goldfish","volume":"151","author":"Nelson ER","year":"2010","unstructured":"Nelson ER & Habibi HR 2010 Functional significance of nuclear estrogen receptor subtypes in the liver of goldfish. Endocrinology 151 1668\u20131676. (https:\/\/doi.org\/10.1210\/en.2009-1447)"},{"key":"bib37","series-title":"Biol Reprod","first-page":"376","article-title":"Kiss1 hexadecapeptide directly regulates gonadotropin-releasing hormone 1 in the scombroid fish, chub mackerel\u2020","volume":"96","author":"Ohga H","year":"2017","unstructured":"Ohga H, Adachi H, Kitano H, et al. 2017 Kiss1 hexadecapeptide directly regulates gonadotropin-releasing hormone 1 in the scombroid fish, chub mackerel\u2020. Biol Reprod 96 376\u2013388. (https:\/\/doi.org\/10.1095\/biolreprod.116.142083)"},{"key":"bib38","series-title":"Biol Reprod","first-page":"259","article-title":"Gonadotropin and activin enhance maturational competence of oocytes in the zebrafish (Danio rerio)1","volume":"66","author":"Pang Y","year":"2002","unstructured":"Pang Y & Ge W 2002 Gonadotropin and activin enhance maturational competence of oocytes in the zebrafish (Danio rerio)1. Biol Reprod 66 259\u2013265. (https:\/\/doi.org\/10.1095\/biolreprod66.2.259)"},{"key":"bib39","series-title":"Proc Natl Acad Sci","first-page":"12435","article-title":"Follicle-stimulating hormone\/cAMP regulation of aromatase gene expression requires \u03b2-catenin","volume":"103","author":"Parakh TN","year":"2006","unstructured":"Parakh TN, Hernandez JA, Grammer JC, et al. 2006 Follicle-stimulating hormone\/cAMP regulation of aromatase gene expression requires \u03b2-catenin. Proc Natl Acad Sci 103 12435\u201312440. (https:\/\/doi.org\/10.1073\/pnas.0603006103)"},{"key":"bib40","series-title":"Mol Cells","first-page":"360","article-title":"Temporal and spatial expression of neurotrophins and their receptors during male germ cell development","volume":"12","author":"Park C","year":"2001","unstructured":"Park C, Choi WS, Kwon H, et al. 2001 Temporal and spatial expression of neurotrophins and their receptors during male germ cell development. Mol Cells 12 360\u2013367. (https:\/\/doi.org\/10.1016\/S1016-8478(23)17109-3)"},{"key":"bib41","series-title":"Science","first-page":"682","article-title":"EGF-like growth factors as mediators of LH action in the ovulatory follicle","volume":"303","author":"Park J-Y","year":"2004","unstructured":"Park J-Y, Su Y-Q, Ariga M, et al. 2004 EGF-like growth factors as mediators of LH action in the ovulatory follicle. Science 303 682\u2013684. (https:\/\/doi.org\/10.1126\/science.1092463)"},{"key":"bib42","series-title":"Horm Behav","first-page":"104980","article-title":"Brain-derived neurotrophic factor (BDNF) affects the activity of the gonadotrophic axis in sheep","volume":"131","author":"Przyby\u0142 BJ","year":"2021","unstructured":"Przyby\u0142 BJ, Szlis M & W\u00f3jcik-G\u0142adysz A 2021 Brain-derived neurotrophic factor (BDNF) affects the activity of the gonadotrophic axis in sheep. Horm Behav 131 104980. (https:\/\/doi.org\/10.1016\/j.yhbeh.2021.104980)"},{"key":"bib43","series-title":"Sci Rep","first-page":"6264","article-title":"Phoenixin-20 stimulates mRNAs encoding hypothalamo-pituitary-gonadal hormones, is pro-vitellogenic, and promotes oocyte maturation in zebrafish","volume":"10","author":"Rajeswari JJ","year":"2020","unstructured":"Rajeswari JJ & Unniappan S 2020 Phoenixin-20 stimulates mRNAs encoding hypothalamo-pituitary-gonadal hormones, is pro-vitellogenic, and promotes oocyte maturation in zebrafish. Sci Rep 10 6264. (https:\/\/doi.org\/10.1038\/s41598-020-63226-x)"},{"key":"bib44","series-title":"Int J Mol Sci","first-page":"10110","article-title":"Actions and roles of FSH in germinative cells","volume":"22","author":"Recchia K","year":"2021","unstructured":"Recchia K, Jorge AS, Pess\u00f4a LVDF, et al. 2021 Actions and roles of FSH in germinative cells. Int J Mol Sci 22 10110. (https:\/\/doi.org\/10.3390\/ijms221810110)"},{"key":"bib45","series-title":"Endocrinology","first-page":"1485","article-title":"Nerve growth factor induces the expression of functional FSH receptors in newly formed follicles of the rat ovary","volume":"143","author":"Romero C","year":"2002","unstructured":"Romero C, Paredes A, Dissen GA, et al. 2002 Nerve growth factor induces the expression of functional FSH receptors in newly formed follicles of the rat ovary. Endocrinology 143 1485\u20131494. (https:\/\/doi.org\/10.1210\/endo.143.4.8711)"},{"key":"bib46","series-title":"Comp Biochem Physiol A: Mol and Integr Physiol","first-page":"111609","article-title":"Intraperitoneal administration of kisspeptin-10 modulates follicle maturation, gonadal steroids, calcium and metabolites in sterlet sturgeon, Acipenser ruthenus","volume":"292","author":"Roosta Z","year":"2024","unstructured":"Roosta Z, Unniappan S, Uju C, et al. 2024 Intraperitoneal administration of kisspeptin-10 modulates follicle maturation, gonadal steroids, calcium and metabolites in sterlet sturgeon, Acipenser ruthenus. Comp Biochem Physiol A: Mol and Integr Physiol 292 111609. (https:\/\/doi.org\/10.1016\/j.cbpa.2024.111609)"},{"key":"bib47","series-title":"Front Endocrinol","first-page":"1225199","article-title":"Mutation of brain aromatase disrupts spawning behavior and reproductive health in female zebrafish","volume":"14","author":"Shaw K","year":"2023","unstructured":"Shaw K, Therrien M, Lu C, et al. 2023 Mutation of brain aromatase disrupts spawning behavior and reproductive health in female zebrafish. Front Endocrinol 14 1225199. (https:\/\/doi.org\/10.3389\/fendo.2023.1225199)"},{"key":"bib48","series-title":"Neurotrophic Factors","first-page":"1","article-title":"Neurotrophic factors: an overview","volume":"1727","author":"Skaper SD","year":"2018","unstructured":"Skaper SD 2018 Neurotrophic factors: an overview. In Neurotrophic Factors, vol 1727, pp 1\u201317. Ed SD Skaper. New York: Springer. (https:\/\/doi.org\/10.1007\/978-1-4939-7571-6_1)"},{"key":"bib50","series-title":"Steroids","first-page":"473","article-title":"Aromatase expression in the ovary: hormonal and molecular regulation","volume":"73","author":"Stocco C","year":"2008","unstructured":"Stocco C 2008 Aromatase expression in the ovary: hormonal and molecular regulation. Steroids 73 473\u2013487. (https:\/\/doi.org\/10.1016\/j.steroids.2008.01.017)"},{"key":"bib51","series-title":"Nat Commun","first-page":"5342","article-title":"Identification of the FSH-RH as the other gonadotropin-releasing hormone","volume":"15","author":"Uehara SK","year":"2024","unstructured":"Uehara SK, Nishiike Y, Maeda K, et al. 2024 Identification of the FSH-RH as the other gonadotropin-releasing hormone. Nat Commun 15 5342. (https:\/\/doi.org\/10.1038\/s41467-024-49564-8)"},{"key":"bib52","series-title":"Mol Cell Endocrinol","first-page":"112091","article-title":"Growth factors and female reproduction in vertebrates","volume":"579","author":"Uju CN","year":"2024","unstructured":"Uju CN & Unniappan S 2024 Growth factors and female reproduction in vertebrates. Mol Cell Endocrinol 579 112091. (https:\/\/doi.org\/10.1016\/j.mce.2023.112091)"},{"key":"bib53","series-title":"Ital J Anat Embryol","first-page":"111","article-title":"Expression of brain derivated neurotrophic factor and of its receptors: TrKB and p75NT in normal and bile duct ligated rat liver [Application\/pdf]","volume":"119","author":"Vivacqua, G","year":"2014","unstructured":"Vivacqua, G, Renzi, A, Carpino, G, et al. 2014 Expression of brain derivated neurotrophic factor and of its receptors: TrKB and p75NT in normal and bile duct ligated rat liver [Application\/pdf]. Ital J Anat Embryol 119 111\u2013129. (https:\/\/doi.org\/10.13128\/IJAE-15138)"},{"key":"bib54","series-title":"Mol Cell Endocrinol","first-page":"110437","article-title":"Fish as models for understanding the vertebrate endocrine regulation of feeding and weight","volume":"497","author":"Volkoff H","year":"2019","unstructured":"Volkoff H 2019 Fish as models for understanding the vertebrate endocrine regulation of feeding and weight. Mol Cell Endocrinol 497 110437. (https:\/\/doi.org\/10.1016\/j.mce.2019.04.017)"},{"key":"bib55","series-title":"J Assisted Reprod Genet","first-page":"1053","article-title":"Brain-derived neurotrophic factor from follicular fluid is positively associated with rate of mature ooocytes collected and cleavage rate in intracytoplasmic sperm injection patients","volume":"28","author":"Wang X","year":"2011","unstructured":"Wang X, Sun Z, Zhen J, et al. 2011 Brain-derived neurotrophic factor from follicular fluid is positively associated with rate of mature ooocytes collected and cleavage rate in intracytoplasmic sperm injection patients. J Assisted Reprod Genet 28 1053\u20131058. (https:\/\/doi.org\/10.1007\/s10815-011-9635-4)"},{"key":"bib56","series-title":"Neurotrophic Factors","first-page":"67","article-title":"Neurotrophins: transcription and translation","volume":"220","author":"West AE","year":"2014","unstructured":"West AE, Pruunsild P & Timmusk T 2014 Neurotrophins: transcription and translation. In Neurotrophic Factors, vol 220, pp 67\u2013100. Eds GR Lewin & BD Carter. Berlin, Heidelberg: Springer. (https:\/\/doi.org\/10.1007\/978-3-642-45106-5_4)"},{"key":"bib57","series-title":"Sci Rep","first-page":"180","article-title":"Brain-derived neurotrophic factor promotes human granulosa-like tumor cell steroidogenesis and proliferation by activating the FSH receptor-mediated signaling pathway","volume":"7","author":"Xie M","year":"2017","unstructured":"Xie M, Li M, Zhou J, et al. 2017 Brain-derived neurotrophic factor promotes human granulosa-like tumor cell steroidogenesis and proliferation by activating the FSH receptor-mediated signaling pathway. Sci Rep 7 180. (https:\/\/doi.org\/10.1038\/s41598-017-00203-x)"},{"key":"bib59","series-title":"Hum Reprod","first-page":"2146","article-title":"Effects of combined epidermal growth factor, brain-derived neurotrophic factor and insulin-like growth factor-1 on human oocyte maturation and early fertilized and cloned embryo development","volume":"27","author":"Yu Y","year":"2012","unstructured":"Yu Y, Yan J, Li M, et al. 2012 Effects of combined epidermal growth factor, brain-derived neurotrophic factor and insulin-like growth factor-1 on human oocyte maturation and early fertilized and cloned embryo development. Hum Reprod 27 2146\u20132159. (https:\/\/doi.org\/10.1093\/humrep\/des099)"},{"key":"bib58","series-title":"Oncotarget","first-page":"24320","article-title":"Zebrafish androgen receptor is required for spermatogenesis and maintenance of ovarian function","volume":"9","author":"Yu G","year":"2018","unstructured":"Yu G, Zhang D, Liu W, et al. 2018 Zebrafish androgen receptor is required for spermatogenesis and maintenance of ovarian function. Oncotarget 9 24320\u201324334. (https:\/\/doi.org\/10.18632\/oncotarget.24407)"},{"key":"bib60","series-title":"Cell Tissue Res","first-page":"185","article-title":"BDNF signaling during the lifetime of dendritic spines","volume":"382","author":"Zagrebelsky M","year":"2020","unstructured":"Zagrebelsky M, Tacke C & Korte M 2020 BDNF signaling during the lifetime of dendritic spines. Cell Tissue Res 382 185\u2013199. (https:\/\/doi.org\/10.1007\/s00441-020-03226-5)"},{"key":"bib61","series-title":"Front Neurosci","first-page":"940","article-title":"The roles of the kisspeptin system in the reproductive physiology of the lined seahorse (Hippocampus erectus), an ovoviviparous fish with male pregnancy","volume":"12","author":"Zhang H","year":"2018","unstructured":"Zhang H, Zhang B, Qin G, et al. 2018 The roles of the kisspeptin system in the reproductive physiology of the lined seahorse (Hippocampus erectus), an ovoviviparous fish with male pregnancy. Front Neurosci 12 940. (https:\/\/doi.org\/10.3389\/fnins.2018.00940)"},{"key":"bib62","series-title":"Hum Reprod","first-page":"695","article-title":"Gonadotrophin-induced paracrine regulation of human oocyte maturation by BDNF and GDNF secreted by granulosa cells","volume":"26","author":"Zhao P","year":"2011","unstructured":"Zhao P, Qiao J, Huang S, et al. 2011 Gonadotrophin-induced paracrine regulation of human oocyte maturation by BDNF and GDNF secreted by granulosa cells. Hum Reprod 26 695\u2013702. (https:\/\/doi.org\/10.1093\/humrep\/deq390)"},{"key":"bib63","series-title":"Theriogenology","first-page":"79","article-title":"Brain-derived neurotrophic factor (BDNF) is expressed in buffalo (Bubalus bubalis) ovarian follicles and promotes oocyte maturation and early embryonic development","volume":"130","author":"Zhao X","year":"2019","unstructured":"Zhao X, Du F, Liu X, et al. 2019 Brain-derived neurotrophic factor (BDNF) is expressed in buffalo (Bubalus bubalis) ovarian follicles and promotes oocyte maturation and early embryonic development. Theriogenology 130 79\u201388. (https:\/\/doi.org\/10.1016\/j.theriogenology.2019.02.020)"},{"key":"bib64","series-title":"Clin Chim Acta","first-page":"44","article-title":"Expression of brain-derived neurotrophic factor in mature spermatozoa from fertile and infertile men","volume":"412","author":"Zheng L","year":"2011","unstructured":"Zheng L, Li C, Sun Y, et al. 2011 Expression of brain-derived neurotrophic factor in mature spermatozoa from fertile and infertile men. Clin Chim Acta 412 44\u201347. (https:\/\/doi.org\/10.1016\/j.cca.2010.08.045)"},{"key":"bib65","series-title":"Animals","first-page":"1115","article-title":"The mechanisms of BDNF promoting the proliferation of porcine follicular granulosa cells: role of miR-127 and involvement of the MAPK-ERK1\/2 pathway","volume":"13","author":"Zheng X","year":"2023","unstructured":"Zheng X, Chen L, Chen T, et al. 2023 The mechanisms of BDNF promoting the proliferation of porcine follicular granulosa cells: role of miR-127 and involvement of the MAPK-ERK1\/2 pathway. Animals 13 1115. (https:\/\/doi.org\/10.3390\/ani13061115)"}],"container-title":["Reproduction"],"original-title":[],"link":[{"URL":"https:\/\/rep.bioscientifica.com\/view\/journals\/rep\/169\/1\/REP-24-0233.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rep.bioscientifica.com\/downloadpdf\/journals\/rep\/169\/1\/REP-24-0233.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rep.bioscientifica.com\/downloadpdf\/journals\/rep\/169\/1\/REP-24-0233.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T23:03:35Z","timestamp":1767567815000},"score":1,"resource":{"primary":{"URL":"https:\/\/rep.bioscientifica.com\/view\/journals\/rep\/169\/1\/REP-24-0233.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,30]]},"references-count":63,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/rep-24-0233","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,30]]}}}