{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T23:19:06Z","timestamp":1767568746774,"version":"3.48.0"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11,24]]},"abstract":"<jats:sec>\n                    <jats:title>In brief<\/jats:title>\n                    <jats:p>Ovarian differentiation in tammar wallabies begins after birth, allowing direct experimental manipulation during the period of differentiation. Using this unique model, we demonstrate that the environmental endocrine-disrupting chemical bisphenol A (BPA) interferes with normal morphological development and gene expression in the developing ovary.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      BPA, an environmental endocrine disruptor, is used widely in the manufacturing of various plastics. While BPA can have detrimental effects on fertility and reproductive health, the effects of BPA on early ovarian differentiation in mammals remain unclear. Marsupials have undifferentiated gonads at birth, so this study investigated the gross morphology, protein localisation of\n                      <jats:italic>FOXL2<\/jats:italic>\n                      and\n                      <jats:italic>FST<\/jats:italic>\n                      and the expression profile of key ovarian differentiating genes\n                      <jats:italic>FOXL2<\/jats:italic>\n                      ,\n                      <jats:italic>WNT4<\/jats:italic>\n                      ,\n                      <jats:italic>FST<\/jats:italic>\n                      ,\n                      <jats:italic>ESR1<\/jats:italic>\n                      and\n                      <jats:italic>ESR2<\/jats:italic>\n                      every 2 days from the day of birth to day 10 postpartum (pp) in the marsupial tammar wallaby. A second group of newborn female pouch young were treated with 50 \u03bcg\/kg of BPA daily from day 0 to day 10 pp, and the morphology and gene expression were examined at day 10 pp. Ovigerous cords in tammar ovaries were first formed between day 2 and day 4 pp.\n                      <jats:italic>FOXL2<\/jats:italic>\n                      localisation became nuclear by day 4 in pre-granulosa cells.\n                      <jats:italic>FST<\/jats:italic>\n                      was initially in the cytoplasm of pre-granulosa cells at day 2 pp but was then secreted into the extracellular matrix in ovaries by day 10 pp.\n                      <jats:italic>FOXL2<\/jats:italic>\n                      ,\n                      <jats:italic>FST<\/jats:italic>\n                      ,\n                      <jats:italic>ESR1<\/jats:italic>\n                      and\n                      <jats:italic>ESR2<\/jats:italic>\n                      mRNA were upregulated in ovaries around day 2\u20134 pp, indicating that ovarian differentiation in the tammar begins from day 2 to day 4 pp. Interestingly, BPA treatment from day 0 to day 10 pp blocked the morphological differentiation of the cortex and medulla and ovigerous cord formation and downregulated the expression of\n                      <jats:italic>FST<\/jats:italic>\n                      and\n                      <jats:italic>FOXL2<\/jats:italic>\n                      at day 10 pp.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/rep-24-0259","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T08:24:47Z","timestamp":1732177487000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":0,"title":["Early ovarian differentiation in the tammar wallaby and the effects of exposure to bisphenol A"],"prefix":"10.1093","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5031-6416","authenticated-orcid":true,"given":"Mario T","family":"Peiris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3948-0788","authenticated-orcid":true,"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7421-7136","authenticated-orcid":true,"given":"Geoff","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4589-0436","authenticated-orcid":true,"given":"Marilyn B","family":"Renfree","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"bib1","series-title":"Reproduction","first-page":"319","article-title":"Germ cell development in female pouch young of the tammar wallaby (Macropus eugenii)","volume":"67","author":"Alcorn G","year":"1983","unstructured":"Alcorn G & Robinson E 1983 Germ cell development in female pouch young of the tammar wallaby (Macropus eugenii). 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