{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:25:51Z","timestamp":1777350351125,"version":"3.51.4"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,3,20]]},"abstract":"<jats:sec>\n                    <jats:title>In brief<\/jats:title>\n                    <jats:p>NAD+ levels were reduced in streptozotocin (STZ)-induced diabetic mice, but nicotinamide riboside (NR) supplementation improved these levels in diabetic ovaries and oocytes, enhancing oocyte quality and early embryo development by improving mitochondrial function and lowering reactive oxygen species (ROS) levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Diabetes mellitus is strongly correlated with a decline in oocyte quality; however, noninvasive and effective methods to improve this issue have yet to be fully development. Here, we demonstrate that\n                      <jats:italic>in vivo<\/jats:italic>\n                      supplementation with NR 400 mg\/kg\/day for 14 days effectively enhances the quality of oocytes from diabetic mice induced by streptozocin 190 mg\/kg by restoring nicotinamide adenine dinucleotide (NAD+) levels. NR supplementation not only improved superovulation function of diabetic mice but also improved their oocyte quality and embryonic development potential after fertilization by maintaining normal spindle structure and alleviating mitochondrial dysfunction. In addition, NR supplementation reduced ROS levels in oocytes from diabetic mice. Overall, our findings suggest that dietary NR supplementation is a viable strategy to protect oocytes from diabetes-related deterioration, thereby enhancing reproductive outcomes in maternal diabetes and improving the efficacy of assisted reproductive technology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/rep-24-0350","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T07:53:30Z","timestamp":1742457210000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":2,"title":["Nicotinamide riboside supplementation protects against maternal diabetes-associated decline in oocyte quality"],"prefix":"10.1093","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1801-7113","authenticated-orcid":true,"given":"Chenlu","family":"Wei","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"},{"name":"Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"},{"name":"Henan Provincial Obstetrical and Gynecological Diseases (Reproductive Medicine) Clinical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5960-6881","authenticated-orcid":true,"given":"Xinxin","family":"Zeng","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"},{"name":"Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"},{"name":"Henan Provincial Obstetrical and Gynecological Diseases (Reproductive Medicine) Clinical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keer","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"},{"name":"Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"},{"name":"Henan Provincial Obstetrical and Gynecological Diseases (Reproductive Medicine) Clinical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengchen","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"},{"name":"Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"},{"name":"Henan Provincial Obstetrical and Gynecological Diseases (Reproductive Medicine) Clinical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Lei","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"},{"name":"Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"},{"name":"Henan Provincial Obstetrical and Gynecological Diseases (Reproductive Medicine) Clinical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenye","family":"Zhu","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"},{"name":"Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"},{"name":"Henan Provincial Obstetrical and Gynecological Diseases (Reproductive Medicine) Clinical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yining","family":"Xu","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"},{"name":"Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"},{"name":"Henan Provincial Obstetrical and Gynecological Diseases (Reproductive Medicine) Clinical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"},{"name":"Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"},{"name":"Henan Provincial Obstetrical and Gynecological Diseases (Reproductive Medicine) Clinical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9187-7961","authenticated-orcid":true,"given":"Qingling","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"},{"name":"Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"},{"name":"Henan Provincial Obstetrical and Gynecological Diseases (Reproductive Medicine) Clinical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3783-6509","authenticated-orcid":true,"given":"Yingpu","family":"Sun","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"},{"name":"Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"},{"name":"Henan Provincial Obstetrical and Gynecological Diseases (Reproductive Medicine) Clinical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"bib1","series-title":"Circulation","first-page":"1795","article-title":"NAD(+) metabolism in cardiac health, aging, and disease","volume":"144","author":"Abdellatif M","year":"2021","unstructured":"Abdellatif M\n, \nSedej S\n & \nKroemer G\n\n 2021 NAD(+) metabolism in cardiac health, aging, and disease. Circulation 144 1795\u20131817. (https:\/\/doi.org\/10.1161\/circulationaha.121.056589)"},{"key":"bib2","series-title":"Curr Nutr Rep","first-page":"445","article-title":"NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR): potential dietary contribution to health","volume":"12","author":"Alegre GFS","year":"2023","unstructured":"Alegre GFS\n & \nPastore GM\n\n 2023 NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR): potential dietary contribution to health. Curr Nutr Rep 12 445\u2013464. (https:\/\/doi.org\/10.1007\/s13668-023-00475-y)"},{"key":"bib3","series-title":"Hum Reprod","first-page":"2217","article-title":"Influence of maternal age on meiotic spindle assembly in oocytes from naturally cycling women","volume":"11","author":"Battaglia DE","year":"1996","unstructured":"Battaglia DE\n, \nGoodwin P\n, \nKlein NA\n, et al.\n 1996 Influence of maternal age on meiotic spindle assembly in oocytes from naturally cycling women. Hum Reprod 11 2217\u20132222. (https:\/\/doi.org\/10.1093\/oxfordjournals.humrep.a019080)"},{"key":"bib4","series-title":"Science","first-page":"2122","article-title":"Role of brain insulin receptor in control of body weight and reproduction","volume":"289","author":"Br\u00fcning JC","year":"2000","unstructured":"Br\u00fcning JC\n, \nGautam D\n, \nBurks DJ\n, et al.\n 2000 Role of brain insulin receptor in control of body weight and reproduction. Science 289 2122\u20132125. (https:\/\/doi.org\/10.1126\/science.289.5487.2122)"},{"key":"bib5","series-title":"PLoS One","article-title":"Mouse estrous cycle identification tool and images","volume":"7","author":"Byers SL","year":"2012","unstructured":"Byers SL\n, \nWiles MV\n, \nDunn SL\n, et al.\n 2012 Mouse estrous cycle identification tool and images. PLoS One 7 e35538. (https:\/\/doi.org\/10.1371\/journal.pone.0035538)"},{"key":"bib6","series-title":"Cell Metab","first-page":"838","article-title":"The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity","volume":"15","author":"Canto C","year":"2012","unstructured":"Canto C\n, \nHoutkooper RH\n, \nPirinen E\n, et al.\n 2012 The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab 15 838\u2013847. (https:\/\/doi.org\/10.1016\/j.cmet.2012.04.022)"},{"key":"bib7","series-title":"Diabetes","first-page":"2602","article-title":"Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats","volume":"55","author":"Castellano JM","year":"2006","unstructured":"Castellano JM\n, \nNavarro VM\n, \nFern\u00e1ndez-Fern\u00e1ndez R\n, et al.\n 2006 Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats. Diabetes 55 2602\u20132610. (https:\/\/doi.org\/10.2337\/db05-1584)"},{"key":"bib8","series-title":"Endocrinology","first-page":"784","article-title":"Alterations in hypothalamic KiSS-1 system in experimental diabetes: early changes and functional consequences","volume":"150","author":"Castellano JM","year":"2009","unstructured":"Castellano JM\n, \nNavarro VM\n, \nRoa J\n, et al.\n 2009 Alterations in hypothalamic KiSS-1 system in experimental diabetes: early changes and functional consequences. Endocrinology 150 784\u2013794. (https:\/\/doi.org\/10.1210\/en.2008-0849)"},{"key":"bib9","series-title":"Int J Mol Sci","first-page":"4887","article-title":"NAD(+) precursors repair mitochondrial function in diabetes and prevent experimental diabetic neuropathy","volume":"23","author":"Chandrasekaran K","year":"2022","unstructured":"Chandrasekaran K\n, \nNajimi N\n, \nSagi AR\n, et al.\n 2022 NAD(+) precursors repair mitochondrial function in diabetes and prevent experimental diabetic neuropathy. Int J Mol Sci 23 4887. (https:\/\/doi.org\/10.3390\/ijms23094887)"},{"key":"bib10","series-title":"Taiwan J Obstet Gynecol","first-page":"877","article-title":"Elevated serum levels of galectin-3 binding protein are associated with insulin resistance in non-diabetic women after menopause","volume":"59","author":"Chen Y","year":"2020","unstructured":"Chen Y\n, \nDas S\n, \nZhuo G\n, et al.\n 2020 Elevated serum levels of galectin-3 binding protein are associated with insulin resistance in non-diabetic women after menopause. Taiwan J Obstet Gynecol 59 877\u2013881. (https:\/\/doi.org\/10.1016\/j.tjog.2020.09.014)"},{"key":"bib11","series-title":"Circ Heart Fail","article-title":"NAD(+) redox imbalance in the heart exacerbates diabetic cardiomyopathy","volume":"14","author":"Chiao YA","year":"2021","unstructured":"Chiao YA\n, \nChakraborty AD\n, \nLight CM\n, et al.\n 2021 NAD(+) redox imbalance in the heart exacerbates diabetic cardiomyopathy. Circ Heart Fail 14 e008170. (https:\/\/doi.org\/10.1161\/circheartfailure.120.008170)"},{"key":"bib12","series-title":"Hum Reprod Update","first-page":"568","article-title":"Female reproduction and type 1 diabetes: from mechanisms to clinical findings","volume":"18","author":"Codner E","year":"2012","unstructured":"Codner E\n, \nMerino PM\n & \nTena-Sempere M\n\n 2012 Female reproduction and type 1 diabetes: from mechanisms to clinical findings. Hum Reprod Update 18 568\u2013585. (https:\/\/doi.org\/10.1093\/humupd\/dms024)"},{"key":"bib13","series-title":"Hum Reprod","first-page":"2397","article-title":"Meiotic spindle location and identification and its effect on embryonic cleavage plane and early development","volume":"18","author":"Cooke S","year":"2003","unstructured":"Cooke S\n, \nTyler JP\n & \nDriscoll GL\n\n 2003 Meiotic spindle location and identification and its effect on embryonic cleavage plane and early development. Hum Reprod 18 2397\u20132405. (https:\/\/doi.org\/10.1093\/humrep\/deg447)"},{"key":"bib14","series-title":"Nat Rev Mol Cell Biol","first-page":"119","article-title":"NAD(+) metabolism and its roles in cellular processes during ageing","volume":"22","author":"Covarrubias AJ","year":"2021","unstructured":"Covarrubias AJ\n, \nPerrone R\n, \nGrozio A\n, et al.\n 2021 NAD(+) metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol 22 119\u2013141. (https:\/\/doi.org\/10.1038\/s41580-020-00313-x)"},{"key":"bib15","series-title":"Cell Cycle","first-page":"491","article-title":"NAD(+) in DNA repair and mitochondrial maintenance","volume":"16","author":"Croteau DL","year":"2017","unstructured":"Croteau DL\n, \nFang EF\n, \nNilsen H\n, et al.\n 2017 NAD(+) in DNA repair and mitochondrial maintenance. Cell Cycle 16 491\u2013492. (https:\/\/doi.org\/10.1080\/15384101.2017.1285631)"},{"key":"bib16","series-title":"Histochem Cell Biol","first-page":"581","article-title":"Immunohistochemical localization of advanced glycation end-products (AGEs) and their receptor (RAGE) in polycystic and normal ovaries","volume":"127","author":"Diamanti-Kandarakis E","year":"2007","unstructured":"Diamanti-Kandarakis E\n, \nPiperi C\n, \nPatsouris E\n, et al.\n 2007 Immunohistochemical localization of advanced glycation end-products (AGEs) and their receptor (RAGE) in polycystic and normal ovaries. Histochem Cell Biol 127 581\u2013589. (https:\/\/doi.org\/10.1007\/s00418-006-0265-3)"},{"key":"bib17","series-title":"J Reprod Fertil","first-page":"1","article-title":"Effects of streptozotocin- and alloxan-induced diabetes mellitus on mouse follicular and early embryo development","volume":"86","author":"Diamond MP","year":"1989","unstructured":"Diamond MP\n, \nMoley KH\n, \nPellicer A\n, et al.\n 1989 Effects of streptozotocin- and alloxan-induced diabetes mellitus on mouse follicular and early embryo development. J Reprod Fertil 86 1\u201310. (https:\/\/doi.org\/10.1530\/jrf.0.0860001)"},{"key":"bib18","series-title":"Metabolism","first-page":"566","article-title":"Dose-response effects of glucose, insulin, and glucagon on mouse pre-embryo development","volume":"40","author":"Diamond MP","year":"1991","unstructured":"Diamond MP\n, \nPettway ZY\n, \nLogan J\n, et al.\n 1991 Dose-response effects of glucose, insulin, and glucagon on mouse pre-embryo development. Metabolism 40 566\u2013570. (https:\/\/doi.org\/10.1016\/0026-0495(91)90045-x)"},{"key":"bib19","series-title":"Diabetes","first-page":"2228","article-title":"AMP kinase activation increases glucose uptake, decreases apoptosis, and improves pregnancy outcome in embryos exposed to high IGF-I concentrations","volume":"56","author":"Eng GS","year":"2007","unstructured":"Eng GS\n, \nSheridan RA\n, \nWyman A\n, et al.\n 2007 AMP kinase activation increases glucose uptake, decreases apoptosis, and improves pregnancy outcome in embryos exposed to high IGF-I concentrations. Diabetes 56 2228\u20132234. (https:\/\/doi.org\/10.2337\/db07-0074)"},{"key":"bib20","series-title":"J Clin Endocrinol Metab","first-page":"4182","article-title":"High prevalence of the polycystic ovary syndrome and hirsutism in women with type 1 diabetes mellitus","volume":"85","author":"Escobar-Morreale HF","year":"2000","unstructured":"Escobar-Morreale HF\n, \nRoldan B\n, \nBarrio R\n, et al.\n 2000 High prevalence of the polycystic ovary syndrome and hirsutism in women with type 1 diabetes mellitus. J Clin Endocrinol Metab 85 4182\u20134187. (https:\/\/doi.org\/10.1210\/jc.85.11.4182)"},{"key":"bib21","series-title":"Front Cell Dev Biol","article-title":"Loss of PDK1 induces meiotic defects in oocytes from diabetic mice","volume":"9","author":"Ge J","year":"2021","unstructured":"Ge J\n, \nZhang N\n, \nTang S\n, et al.\n 2021 Loss of PDK1 induces meiotic defects in oocytes from diabetic mice. Front Cell Dev Biol 9 793389. (https:\/\/doi.org\/10.3389\/fcell.2021.793389)"},{"key":"bib22","series-title":"Cell Mol Life Sci","first-page":"251","article-title":"Metabolic control of oocyte development: linking maternal nutrition and reproductive outcomes","volume":"72","author":"Gu L","year":"2015","unstructured":"Gu L\n, \nLiu H\n, \nGu X\n, et al.\n 2015 Metabolic control of oocyte development: linking maternal nutrition and reproductive outcomes. Cell Mol Life Sci 72 251\u2013271. (https:\/\/doi.org\/10.1007\/s00018-014-1739-4)"},{"key":"bib23","series-title":"Hum Reprod Update","first-page":"583","article-title":"Evaluating interventions and adjuncts to optimize pregnancy outcomes in subfertile women: an overview review","volume":"28","author":"Holt-Kentwell A","year":"2022","unstructured":"Holt-Kentwell A\n, \nGhosh J\n, \nDevall A\n, et al.\n 2022 Evaluating interventions and adjuncts to optimize pregnancy outcomes in subfertile women: an overview review. Hum Reprod Update 28 583\u2013600. (https:\/\/doi.org\/10.1093\/humupd\/dmac001)"},{"key":"bib24","series-title":"Front Cell Dev Biol","first-page":"246","article-title":"Nicotinamide mononucleotide: a promising molecule for therapy of diverse diseases by targeting NAD+ metabolism","volume":"8","author":"Hong W","year":"2020","unstructured":"Hong W\n, \nMo F\n, \nZhang Z\n, et al.\n 2020 Nicotinamide mononucleotide: a promising molecule for therapy of diverse diseases by targeting NAD+ metabolism. Front Cell Dev Biol 8 246. (https:\/\/doi.org\/10.3389\/fcell.2020.00246)"},{"key":"bib25","series-title":"Cell Physiol Biochem","first-page":"2320","article-title":"Effect of type I diabetes on the proteome of mouse oocytes","volume":"39","author":"Jiang G","year":"2016","unstructured":"Jiang G\n, \nZhang G\n, \nAn T\n, et al.\n 2016 Effect of type I diabetes on the proteome of mouse oocytes. Cell Physiol Biochem 39 2320\u20132330. (https:\/\/doi.org\/10.1159\/000447924)"},{"key":"bib26","series-title":"Pharmacol Res","first-page":"274","article-title":"NAD(+) salvage pathway in cancer metabolism and therapy","volume":"114","author":"Kennedy BE","year":"2016","unstructured":"Kennedy BE\n, \nSharif T\n, \nMartell E\n, et al.\n 2016 NAD(+) salvage pathway in cancer metabolism and therapy. Pharmacol Res 114 274\u2013283. (https:\/\/doi.org\/10.1016\/j.phrs.2016.10.027)"},{"key":"bib27","series-title":"J Clin Endocrinol Metab","first-page":"524","article-title":"Epidemiology of menarche and menstrual disturbances in an unselected group of women with insulin-dependent diabetes mellitus compared to controls","volume":"75","author":"Kjaer K","year":"1992","unstructured":"Kjaer K\n, \nHagen C\n, \nSando SH\n, et al.\n 1992 Epidemiology of menarche and menstrual disturbances in an unselected group of women with insulin-dependent diabetes mellitus compared to controls. J Clin Endocrinol Metab 75 524\u2013529. (https:\/\/doi.org\/10.1210\/jc.75.2.524)"},{"key":"bib28","series-title":"Cell Metab","first-page":"630","article-title":"NAD(+) in brain aging and neurodegenerative disorders","volume":"30","author":"Lautrup S","year":"2019","unstructured":"Lautrup S\n, \nSinclair DA\n, \nMattson MP\n, et al.\n 2019 NAD(+) in brain aging and neurodegenerative disorders. Cell Metab 30 630\u2013655. (https:\/\/doi.org\/10.1016\/j.cmet.2019.09.001)"},{"key":"bib29","series-title":"Yonsei Med J","first-page":"667","article-title":"Poorly-Controlled type 1 diabetes mellitus impairs LH-LHCGR signaling in the ovaries and decreases female fertility in mice","volume":"60","author":"Lee J","year":"2019","unstructured":"Lee J\n, \nLee HC\n, \nKim SY\n, et al.\n 2019 Poorly-Controlled type 1 diabetes mellitus impairs LH-LHCGR signaling in the ovaries and decreases female fertility in mice. Yonsei Med J 60 667\u2013678. (https:\/\/doi.org\/10.3349\/ymj.2019.60.7.667)"},{"key":"bib30","series-title":"Free Radic Biol Med","first-page":"386","article-title":"Melatonin protects against maternal diabetes-associated meiotic defects by maintaining mitochondrial function","volume":"188","author":"Li XQ","year":"2022","unstructured":"Li XQ\n, \nWang Y\n, \nYang SJ\n, et al.\n 2022 Melatonin protects against maternal diabetes-associated meiotic defects by maintaining mitochondrial function. Free Radic Biol Med 188 386\u2013394. (https:\/\/doi.org\/10.1016\/j.freeradbiomed.2022.06.243)"},{"key":"bib31","series-title":"Reproduction","first-page":"103","article-title":"Nicotinamide riboside supplementation ameliorated post-ovulatory oocyte quality decline","volume":"165","author":"Li H","year":"2023","unstructured":"Li H\n, \nWang H\n, \nXu J\n, et al.\n 2023 Nicotinamide riboside supplementation ameliorated post-ovulatory oocyte quality decline. Reproduction 165 103\u2013111. (https:\/\/doi.org\/10.1530\/rep-22-0095)"},{"key":"bib32","series-title":"Food Funct","first-page":"5396","article-title":"Tea polyphenols alleviate the adverse effects of diabetes on oocyte quality","volume":"13","author":"Lu J","year":"2022","unstructured":"Lu J\n, \nZhao SX\n, \nZhang MY\n, et al.\n 2022 Tea polyphenols alleviate the adverse effects of diabetes on oocyte quality. Food Funct 13 5396\u20135405. (https:\/\/doi.org\/10.1039\/d1fo03770f)"},{"key":"bib33","series-title":"Cell Metab","first-page":"795","article-title":"Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice","volume":"24","author":"Mills KF","year":"2016","unstructured":"Mills KF\n, \nYoshida S\n, \nStein LR\n, et al.\n 2016 Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metab 24 795\u2013806. (https:\/\/doi.org\/10.1016\/j.cmet.2016.09.013)"},{"key":"bib34","series-title":"Cell Metab","first-page":"667","article-title":"Nicotinamide improves aspects of healthspan, but not lifespan, in mice","volume":"27","author":"Mitchell SJ","year":"2018","unstructured":"Mitchell SJ\n, \nBernier M\n, \nAon MA\n, et al.\n 2018 Nicotinamide improves aspects of healthspan, but not lifespan, in mice. Cell Metab 27 667\u2013676 e4. (https:\/\/doi.org\/10.1016\/j.cmet.2018.02.001)"},{"key":"bib35","series-title":"Am J Physiol","first-page":"E38","article-title":"Maternal hyperglycemia alters glucose transport and utilization in mouse preimplantation embryos","volume":"275","author":"Moley KH","year":"1998","unstructured":"Moley KH\n, \nChi MM\n & \nMueckler MM\n\n 1998 Maternal hyperglycemia alters glucose transport and utilization in mouse preimplantation embryos. Am J Physiol 275 E38\u2013E47. (https:\/\/doi.org\/10.1152\/ajpendo.1998.275.1.e38)"},{"key":"bib36","series-title":"Elife","article-title":"A single-cell atlas of the cycling murine ovary","volume":"11","author":"Morris ME","year":"2022","unstructured":"Morris ME\n, \nMeinsohn MC\n, \nChauvin M\n, et al.\n 2022 A single-cell atlas of the cycling murine ovary. Elife 11 e77239. (https:\/\/doi.org\/10.7554\/elife.77239)"},{"key":"bib37","series-title":"Circ Res","first-page":"114","article-title":"Nampt potentiates antioxidant defense in diabetic cardiomyopathy","volume":"129","author":"Oka SI","year":"2021","unstructured":"Oka SI\n, \nByun J\n, \nHuang CY\n, et al.\n 2021 Nampt potentiates antioxidant defense in diabetic cardiomyopathy. Circ Res 129 114\u2013130. (https:\/\/doi.org\/10.1161\/circresaha.120.317943)"},{"key":"bib38","series-title":"Vet Sci","first-page":"439","article-title":"Importance of antioxidant supplementation during in vitro maturation of mammalian oocytes","volume":"9","author":"Rakha SI","year":"2022","unstructured":"Rakha SI\n, \nElmetwally MA\n, \nEl-Sheikh Ali H\n, et al.\n 2022 Importance of antioxidant supplementation during in vitro maturation of mammalian oocytes. Vet Sci 9 439. (https:\/\/doi.org\/10.3390\/vetsci9080439)"},{"key":"bib39","series-title":"Hum Reprod Update","first-page":"553","article-title":"Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells","volume":"15","author":"Ramalho-Santos J","year":"2009","unstructured":"Ramalho-Santos J\n, \nVarum S\n, \nAmaral S\n, et al.\n 2009 Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells. Hum Reprod Update 15 553\u2013572. (https:\/\/doi.org\/10.1093\/humupd\/dmp016)"},{"key":"bib40","series-title":"Front Endocrinol","article-title":"The impact of maternal diabetes on the future health and neurodevelopment of the offspring: a review of the evidence","volume":"14","author":"Rodolaki K","year":"2023","unstructured":"Rodolaki K\n, \nPergialiotis V\n, \nIakovidou N\n, et al.\n 2023 The impact of maternal diabetes on the future health and neurodevelopment of the offspring: a review of the evidence. Front Endocrinol 14 1125628. (https:\/\/doi.org\/10.3389\/fendo.2023.1125628)"},{"key":"bib41","series-title":"Antioxidants","first-page":"1939","article-title":"Therapeutic potential of emerging NAD+-Increasing strategies for cardiovascular diseases","volume":"10","author":"Rotllan N","year":"2021","unstructured":"Rotllan N\n, \nCamacho M\n, \nTondo M\n, et al.\n 2021 Therapeutic potential of emerging NAD+-Increasing strategies for cardiovascular diseases. Antioxidants 10 1939. (https:\/\/doi.org\/10.3390\/antiox10121939)"},{"key":"bib42","series-title":"mSystems","article-title":"Metabolic disease, NAD metabolism, nicotinamide riboside, and the gut microbiome: connecting the dots from the gut to physiology","volume":"7","author":"Sauve AA","year":"2022","unstructured":"Sauve AA\n\n 2022 Metabolic disease, NAD metabolism, nicotinamide riboside, and the gut microbiome: connecting the dots from the gut to physiology. mSystems 7 e0122321. (https:\/\/doi.org\/10.1128\/msystems.01223-21)"},{"key":"bib43","series-title":"Reprod Biol Endocrinol","first-page":"111","article-title":"The impact of mitochondrial function\/dysfunction on IVF and new treatment possibilities for infertility","volume":"12","author":"Schatten H","year":"2014","unstructured":"Schatten H\n, \nSun QY\n & \nPrather R\n\n 2014 The impact of mitochondrial function\/dysfunction on IVF and new treatment possibilities for infertility. Reprod Biol Endocrinol 12 111. (https:\/\/doi.org\/10.1186\/1477-7827-12-111)"},{"key":"bib44","series-title":"Diabetologia","first-page":"78","article-title":"Fertility in people with childhood-onset type 1 diabetes","volume":"56","author":"Sjoberg L","year":"2013","unstructured":"Sjoberg L\n, \nPitkaniemi J\n, \nHaapala L\n, et al.\n 2013 Fertility in people with childhood-onset type 1 diabetes. Diabetologia 56 78\u201381. (https:\/\/doi.org\/10.1007\/s00125-012-2731-x)"},{"key":"bib45","series-title":"J Assist Reprod Genet","first-page":"929","article-title":"Dynamic changes in mitochondrial distribution in human oocytes during meiotic maturation","volume":"33","author":"Takahashi Y","year":"2016","unstructured":"Takahashi Y\n, \nHashimoto S\n, \nYamochi T\n, et al.\n 2016 Dynamic changes in mitochondrial distribution in human oocytes during meiotic maturation. J Assist Reprod Genet 33 929\u2013938. (https:\/\/doi.org\/10.1007\/s10815-016-0716-2)"},{"key":"bib46","series-title":"Lancet Diabetes Endocrinol","first-page":"134","article-title":"Diabetes: a metabolic and reproductive disorder in women","volume":"8","author":"Thong EP","year":"2020","unstructured":"Thong EP\n, \nCodner E\n, \nLaven JSE\n, et al.\n 2020 Diabetes: a metabolic and reproductive disorder in women. Lancet Diabetes Endocrinol 8 134\u2013149. (https:\/\/doi.org\/10.1016\/s2213-8587(19)30345-6)"},{"key":"bib47","series-title":"Mol Hum Reprod","first-page":"759","article-title":"Mitochondrial signaling and fertilization","volume":"13","author":"Van Blerkom J","year":"2007","unstructured":"Van Blerkom J\n & \nDavis P\n\n 2007 Mitochondrial signaling and fertilization. Mol Hum Reprod 13 759\u2013770. (https:\/\/doi.org\/10.1093\/molehr\/gam068)"},{"key":"bib48","series-title":"J Reprod Fertil","first-page":"561","article-title":"Effects of healthy pseudopregnant milieu on development of two-cell subdiabetic mouse embryos","volume":"100","author":"Vesela J","year":"1994","unstructured":"Vesela J\n, \nRehak P\n, \nBaran V\n, et al.\n 1994 Effects of healthy pseudopregnant milieu on development of two-cell subdiabetic mouse embryos. J Reprod Fertil 100 561\u2013565. (https:\/\/doi.org\/10.1530\/jrf.0.1000561)"},{"key":"bib49","series-title":"Mol Endocrinol","first-page":"1603","article-title":"Maternal diabetes causes mitochondrial dysfunction and meiotic defects in murine oocytes","volume":"23","author":"Wang Q","year":"2009","unstructured":"Wang Q\n, \nRatchford AM\n, \nChi MM\n, et al.\n 2009 Maternal diabetes causes mitochondrial dysfunction and meiotic defects in murine oocytes. Mol Endocrinol 23 1603\u20131612. (https:\/\/doi.org\/10.1210\/me.2009-0033)"},{"key":"bib50","series-title":"Endocrinology","first-page":"1984","article-title":"Live imaging reveals the link between decreased glucose uptake in ovarian cumulus cells and impaired oocyte quality in female diabetic mice","volume":"153","author":"Wang Q","year":"2012","unstructured":"Wang Q\n, \nChi MM\n & \nMoley KH\n\n 2012 Live imaging reveals the link between decreased glucose uptake in ovarian cumulus cells and impaired oocyte quality in female diabetic mice. Endocrinology 153 1984\u20131989. (https:\/\/doi.org\/10.1210\/en.2011-1815)"},{"key":"bib51","series-title":"Endocrinology","first-page":"466","article-title":"One-cell zygote transfer from diabetic to nondiabetic mouse results in congenital malformations and growth retardation in offspring","volume":"149","author":"Wyman A","year":"2008","unstructured":"Wyman A\n, \nPinto AB\n, \nSheridan R\n, et al.\n 2008 One-cell zygote transfer from diabetic to nondiabetic mouse results in congenital malformations and growth retardation in offspring. Endocrinology 149 466\u2013469. (https:\/\/doi.org\/10.1210\/en.2007-1273)"},{"key":"bib52","series-title":"Signal Transduct Target Ther","first-page":"227","article-title":"NAD(+) metabolism: pathophysiologic mechanisms and therapeutic potential","volume":"5","author":"Xie N","year":"2020","unstructured":"Xie N\n, \nZhang L\n, \nGao W\n, et al.\n 2020 NAD(+) metabolism: pathophysiologic mechanisms and therapeutic potential. Signal Transduct Target Ther 5 227. (https:\/\/doi.org\/10.1038\/s41392-020-00311-7)"},{"key":"bib53","series-title":"Cell Prolif","article-title":"Involvement of SIRT3-GSK3beta deacetylation pathway in the effects of maternal diabetes on oocyte meiosis","volume":"54","author":"Xin Y","year":"2021","unstructured":"Xin Y\n, \nJin Y\n, \nGe J\n, et al.\n 2021 Involvement of SIRT3-GSK3beta deacetylation pathway in the effects of maternal diabetes on oocyte meiosis. Cell Prolif 54 e12940. (https:\/\/doi.org\/10.1111\/cpr.12940)"},{"key":"bib54","series-title":"Ageing Res Rev","first-page":"1","article-title":"NAD metabolism: implications in aging and longevity","volume":"47","author":"Yaku K","year":"2018","unstructured":"Yaku K\n, \nOkabe K\n & \nNakagawa T\n\n 2018 NAD metabolism: implications in aging and longevity. Ageing Res Rev 47 1\u201317. (https:\/\/doi.org\/10.1016\/j.arr.2018.05.006)"},{"key":"bib55","series-title":"Free Radic Biol Med","first-page":"1","article-title":"Increasing ovarian NAD(+) levels improve mitochondrial functions and reverse ovarian aging","volume":"156","author":"Yang Q","year":"2020","unstructured":"Yang Q\n, \nCong L\n, \nWang Y\n, et al.\n 2020 Increasing ovarian NAD(+) levels improve mitochondrial functions and reverse ovarian aging. Free Radic Biol Med 156 1\u201310. (https:\/\/doi.org\/10.1016\/j.freeradbiomed.2020.05.003)"},{"key":"bib56","series-title":"Clin Transl Med","article-title":"NAD(+) repletion attenuates obesity-induced oocyte mitochondrial dysfunction and offspring metabolic abnormalities via a SIRT3-dependent pathway","volume":"11","author":"Yang Q","year":"2021","unstructured":"Yang Q\n, \nWang Y\n, \nWang H\n, et al.\n 2021 NAD(+) repletion attenuates obesity-induced oocyte mitochondrial dysfunction and offspring metabolic abnormalities via a SIRT3-dependent pathway. Clin Transl Med 11 e628. (https:\/\/doi.org\/10.1002\/ctm2.628)"},{"key":"bib62","series-title":"Aging Cell","first-page":"e13904","article-title":"Deletion of enzymes for de novo NAD(+) biosynthesis accelerated ovarian aging.","volume":"22","author":"Yang QL","year":"2023","unstructured":"Yang QL\n, \nLi H\n, \nWang H\n, et al\n. 2023 Deletion of enzymes for de novo NAD(+) biosynthesis accelerated ovarian aging. Aging Cell 22 e13904. (https:\/\/doi.org\/10.1111\/acel.13904)"},{"key":"bib57","series-title":"Cell Metab","first-page":"528","article-title":"Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice","volume":"14","author":"Yoshino J","year":"2011","unstructured":"Yoshino J\n, \nMills KF\n, \nYoon MJ\n, et al.\n 2011 Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab 14 528\u2013536. (https:\/\/doi.org\/10.1016\/j.cmet.2011.08.014)"},{"key":"bib60","series-title":"Reprod Biol Endocrinol","first-page":"27","article-title":"Effects of adverse fertility-related factors on mitochondrial DNA in the oocyte: a comprehensive review","volume":"21","author":"Zhang W","year":"2023","unstructured":"Zhang W\n & \nWu F\n\n 2023 Effects of adverse fertility-related factors on mitochondrial DNA in the oocyte: a comprehensive review. Reprod Biol Endocrinol 21 27. (https:\/\/doi.org\/10.1186\/s12958-023-01078-6)"},{"key":"bib58","series-title":"Reprod Biol Endocrinol","first-page":"31","article-title":"Maternal diabetes causes abnormal dynamic changes of endoplasmic reticulum during mouse oocyte maturation and early embryo development","volume":"11","author":"Zhang CH","year":"2013","unstructured":"Zhang CH\n, \nQian WP\n, \nQi ST\n, et al.\n 2013 Maternal diabetes causes abnormal dynamic changes of endoplasmic reticulum during mouse oocyte maturation and early embryo development. Reprod Biol Endocrinol 11 31. (https:\/\/doi.org\/10.1186\/1477-7827-11-31)"},{"key":"bib59","series-title":"Reprod Biomed Online","article-title":"Poorly controlled type 1 diabetes mellitus seriously impairs female reproduction via immune and metabolic disorders","volume":"48","author":"Zhang S","year":"2024","unstructured":"Zhang S\n, \nLiu Q\n, \nYang C\n, et al.\n 2024 Poorly controlled type 1 diabetes mellitus seriously impairs female reproduction via immune and metabolic disorders. Reprod Biomed Online 48 103727. (https:\/\/doi.org\/10.1016\/j.rbmo.2023.103727)"},{"key":"bib61","series-title":"Sci Rep","article-title":"Maternal diabetes causes developmental delay and death in early-somite mouse embryos","volume":"7","author":"Zhao J","year":"2017","unstructured":"Zhao J\n, \nHakvoort TBM\n, \nRuijter JM\n, et al.\n 2017 Maternal diabetes causes developmental delay and death in early-somite mouse embryos. Sci Rep 7 11714. 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