{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T15:03:42Z","timestamp":1781967822513,"version":"3.54.5"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"4","funder":[{"DOI":"10.13039\/501100006447","name":"Universit\u00e4t Z\u00fcrich","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006447","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,3,14]]},"abstract":"<jats:sec>\n                    <jats:title>In brief<\/jats:title>\n                    <jats:p>\n                      The role of inflammation in the regulation of pregnancy remains poorly understood in dogs. Findings from this study propose the involvement of IL1\u03b2 signaling during early embryo-maternal interactions in the dog, while\n                      <jats:italic>in vitro<\/jats:italic>\n                      effects suggest it may disrupt decidual cell function in the canine mature placenta.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Although implantation and parturition are associated with pro-inflammatory signals, inflammatory responses in the mature placenta frequently lead to pregnancy loss. Indeed, uterine inflammatory\/infectious diseases are major causes of infertility and pregnancy loss in dogs. The pro-inflammatory interleukin (IL)-1\u03b2 is increased during canine placentation and downregulated in mature placentae during healthy pregnancies but is enriched in the placenta during infectious events. Furthermore, canine pregnancy success is linked with decidual cells, the only placental cells expressing the nuclear progesterone receptor. This study assessed utero-placental abundance of IL1\u03b2 receptor 1 (IL1R1) throughout canine pregnancy and possible modulatory effects of IL1\u03b2 on decidualization. The mRNA levels of\n                      <jats:italic>IL1R1<\/jats:italic>\n                      were increased in mature mid-gestation placentae and at term (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05). Immunohistochemistry co-localized IL1\u03b2 and IL1R1 in the trophoblast during early placentation, implicating IL1\u03b2-signaling in early embryo-maternal communication. In the mature placenta, IL1R1 was localized, i.a. in decidual cells.\n                      <jats:italic>In vitro<\/jats:italic>\n                      , IL1\u03b2 had low modulatory effects on PGE2- and\/or P4-stimulated dog uterine stromal (DUS) cells, implying a relatively weak impact of this interleukin in the decidualization process. However, in DUS cells decidualized with cAMP, IL1\u03b2 decreased transcriptional amounts of selected decidualization markers\n                      <jats:italic>IGF1<\/jats:italic>\n                      ,\n                      <jats:italic>PTGS2<\/jats:italic>\n                      and\n                      <jats:italic>PTGES<\/jats:italic>\n                      , as well as\n                      <jats:italic>ECM1<\/jats:italic>\n                      and\n                      <jats:italic>TIMP2<\/jats:italic>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). Transcriptional and protein availabilities of CX43, a gap junction component, were also decreased by IL1\u03b2 (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). These findings support a dual role for IL1\u03b2 in canine pregnancy: involvement in early embryo-maternal communication during its establishment and disturbing placental homeostasis by disrupting decidual cell function in fully developed placenta.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/rep-24-0470","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T09:34:17Z","timestamp":1741944857000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":2,"title":["Placental interleukin 1\u03b2 signaling in canine pregnancy: differential effects during and after decidualization in vitro"],"prefix":"10.1093","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0537-5675","authenticated-orcid":true,"given":"Miguel","family":"Tavares Pereira","sequence":"first","affiliation":[{"name":"Institute of Veterinary Anatomy, Vetsuisse Faculty, University of Zurich (UZH), Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selim","family":"Aslan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Near East University, Nicosia, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Payan-Carreira","sequence":"additional","affiliation":[{"name":"School of Science and Technology, Department of Veterinary Medicine, University of \u00c9vora, \u00c9vora, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris M","family":"Reichler","sequence":"additional","affiliation":[{"name":"Clinic for Reproductive Medicine, Vetsuisse Faculty, University of Zurich (UZH), Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Reynaud","sequence":"additional","affiliation":[{"name":"\u00c9cole Nationale V\u00e9t\u00e9rinaire d'Alfort, EnvA, Maisons-Alfort, France"},{"name":"Physiologie de la Reproduction et des Comportements, CNRS, IFCE, INRAE, Universit\u00e9 de Tours, PRC, Nouzilly, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4565-7714","authenticated-orcid":true,"given":"Mariusz P","family":"Kowalewski","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Anatomy, Vetsuisse Faculty, University of Zurich (UZH), Zurich, Switzerland"},{"name":"Center for Clinical Studies (ZKS), Vetsuisse Faculty, University of Zurich (UZH), Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"bib1","series-title":"Marshall's Physiology of Reproduction","article-title":"Placentation","author":"Amoroso EC","year":"1952","unstructured":"Amoroso EC\n\n 1952 Placentation. 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