{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:36:03Z","timestamp":1790044563960,"version":"4.0.1"},"reference-count":175,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10,13]]},"abstract":"\n In brief<\/jats:title>\n Early clinical manifestations of PCOS may begin during puberty. This paper reviews the initial characteristics of PCOS in the adolescent girl.<\/jats:p>\n <\/jats:sec>\n \n Abstract<\/jats:title>\n Polycystic ovary syndrome (PCOS) is a heterogeneous multi-factorial familial disorder characterized by androgen excess, irregular menses, and chronic anovulation. The key features, hyperandrogenism, insulin resistance, and hyperinsulinemia, can be identified in peripubertal girls. From a pediatric\/adolescent point of view, the ability to identify girls with PCOS or those \u2018at-risk for PCOS\u2019 is crucial to target educational and medical resources to promote healthy lifestyle interventions for these girls to minimize progression to PCOS and curtail the associated comorbidities.<\/jats:p>\n <\/jats:sec>","DOI":"10.1530\/rep-25-0115","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T10:44:07Z","timestamp":1760352247000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":4,"title":["POLYCYSTIC OVARY SYNDROME: ORIGINS AND IMPLICATIONS: PCOS in adolescents: ontogeny of neuroendocrine and metabolic disturbances"],"prefix":"10.1093","volume":"170","author":[{"given":"Hala","family":"Tfayli","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Division of Pediatric Endocrinology, American University of Beirut, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silva","family":"Arslanian","sequence":"additional","affiliation":[{"name":"Center for Pediatric Research in Obesity and Metabolism and Division of Pediatric Endocrinology, UPMC Children\u2019s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA"},{"name":"Division of Pediatric Endocrinology, UPMC Children\u2019s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5178-5897","authenticated-orcid":true,"given":"Selma Feldman","family":"Witchel","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, UPMC Children\u2019s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"bib1","series-title":"Expert Rev Endocrinol Metab","first-page":"131","article-title":"Hyperandrogenic origins of polycystic ovary syndrome \u2013 implications for pathophysiology and therapy","volume":"14","author":"Abbott DH","year":"2019","unstructured":"Abbott DH\n, \nDumesic DA\n & \nLevine JE\n\n 2019 Hyperandrogenic origins of polycystic ovary syndrome \u2013 implications for pathophysiology and therapy. 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