{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:09:24Z","timestamp":1791994164670,"version":"4.4.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"2","funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"crossref","award":["PI1801122, PI2100116"],"award-info":[{"award-number":["PI1801122, PI2100116"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6,24]]},"abstract":"<jats:sec>\n                    <jats:title>In brief<\/jats:title>\n                    <jats:p>Cardiometabolic risk factors may cluster in women with polycystic ovary syndrome (PCOS) from early ages. This narrative review suggests that the long-term prognosis of PCOS is better than expected from these associations, provided that obesity is avoided and the disorder is properly managed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Polycystic ovary syndrome (PCOS) is a widespread condition, with reported prevalences ranging from 5 to 20% in premenopausal women worldwide. Being a chronic hyperandrogenic condition, cardiovascular risk factors cluster even in young adult women with the syndrome because its pathophysiology also involves dysfunctional adipose tissue, chronic low-grade subclinical inflammation and\/or insulin resistance. Recent systematic reviews and meta-analyses of available studies suggest that middle-aged and postmenopausal women with PCOS might present with an increased risk of cardiovascular events, namely myocardial infarction and stroke, when compared with non-hyperandrogenic women from the general population. Hyperandrogenic and metabolic complaints of PCOS also have a negative impact on the mental health of this broad segment of the population. However, obesity played a major role in these associations: when comparing populations matched for weight, the cardiovascular risk of women with PCOS appears to be similar to that of women without this condition, even though postmenopausal patients retain their hyperandrogenic features. Importantly, recent results from a longitudinal prospective cohort study failed to demonstrate increased cardiovascular events during the late reproductive or early postmenopausal period of Caucasian patients with PCOS after 10 years of follow-up, even though cardiovascular risk factors were very frequent in these patients. Hence, current evidence indicates that the long-term prognosis of PCOS is somehow better than that expected from their cardiometabolic associations, which are largely driven by the association of PCOS with obesity. Nevertheless, physicians attending these women must still be aware of the potential health consequences of PCOS during their late reproductive years and beyond menopause, in order to identify and properly manage these high-risk patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/rep-25-0118","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T16:32:30Z","timestamp":1752165150000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":12,"title":["POLYCYSTIC OVARY SYNDROME: ORIGINS AND IMPLICATIONS: Long-term health outcomes in polycystic ovary syndrome"],"prefix":"10.1093","volume":"170","author":[{"given":"Anuja","family":"Dokras","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Luque-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Diabetes, Obesity and Human Reproduction Research Group, University of Alcal\u00e1 & Hospital Universitario Ram\u00f3n y Cajal & Centro de Investigaci\u00f3n Biom\u00e9dica en Red Diabetes y Enfermedades Metab\u00f3licas Asociadas CIBERDEM & Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria IRYCIS, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6890-1644","authenticated-orcid":true,"given":"H\u00e9ctor F","family":"Escobar-Morreale","sequence":"additional","affiliation":[{"name":"Diabetes, Obesity and Human Reproduction Research Group, University of Alcal\u00e1 & Hospital Universitario Ram\u00f3n y Cajal & Centro de Investigaci\u00f3n Biom\u00e9dica en Red Diabetes y Enfermedades Metab\u00f3licas Asociadas CIBERDEM & Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria IRYCIS, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"bib1","series-title":"Arch Intern Med","first-page":"2081","article-title":"Prevalence and characteristics of the polycystic ovary syndrome in overweight and obese women","volume":"166","author":"\u00c1lvarez-Blasco F","year":"2006","unstructured":"\u00c1lvarez-Blasco F\n, \nBotella-Carretero JI\n, \nSan Millan JL\n, et al.\n 2006 Prevalence and characteristics of the polycystic ovary syndrome in overweight and obese women. Arch Intern Med 166 2081\u20132086. (https:\/\/doi.org\/10.1001\/archinte.166.19.2081)"},{"key":"bib2","series-title":"Horm Metab Res","first-page":"22","article-title":"Relationships between biochemical markers of hyperandrogenism and metabolic parameters in women with polycystic ovary syndrome: a systematic review and meta-analysis","volume":"51","author":"Amiri M","year":"2019","unstructured":"Amiri M\n, \nTehrani FR\n, \nBidhendi-Yarandi R\n, et al.\n 2019 Relationships between biochemical markers of hyperandrogenism and metabolic parameters in women with polycystic ovary syndrome: a systematic review and meta-analysis. Horm Metab Res 51 22\u201334. (https:\/\/doi.org\/10.1055\/a-0806-8281)"},{"key":"bib3","series-title":"Menopause","first-page":"130","article-title":"A prospective study on the relationship between polycystic ovary syndrome and age at natural menopause","volume":"31","author":"Amiri M","year":"2024","unstructured":"Amiri M\n, \nRahmati M\n, \nFirouzi F\n, et al.\n 2024 A prospective study on the relationship between polycystic ovary syndrome and age at natural menopause. Menopause 31 130\u2013137. (https:\/\/doi.org\/10.1097\/gme.0000000000002213)"},{"key":"bib4","series-title":"Hum Reprod Update","first-page":"501","article-title":"Prevalence of PCOS and related hyperandrogenic traits in premenopausal women with type 1 diabetes: a systematic review and meta-analysis","volume":"28","author":"Bayona A","year":"2022","unstructured":"Bayona A\n, \nMartinez-Vaello V\n, \nZamora J\n, et al.\n 2022 Prevalence of PCOS and related hyperandrogenic traits in premenopausal women with type 1 diabetes: a systematic review and meta-analysis. Hum Reprod Update 28 501\u2013517. (https:\/\/doi.org\/10.1093\/humupd\/dmac011)"},{"key":"bib5","series-title":"Endocrine","first-page":"318","article-title":"Psychiatric disorders in women with polycystic ovary syndrome: a systematic review and meta-analysis","volume":"62","author":"Brutocao C","year":"2018","unstructured":"Brutocao C\n, \nZaiem F\n, \nAlsawas M\n, et al.\n 2018 Psychiatric disorders in women with polycystic ovary syndrome: a systematic review and meta-analysis. Endocrine 62 318\u2013325. (https:\/\/doi.org\/10.1007\/s12020-018-1692-3)"},{"key":"bib6","series-title":"Obstet Gynecol","first-page":"263","article-title":"A 20-year follow-up of young women with polycystic ovary syndrome","volume":"119","author":"Carmina E","year":"2012","unstructured":"Carmina E\n, \nCampagna AM\n & \nLobo RA\n\n 2012 A 20-year follow-up of young women with polycystic ovary syndrome. Obstet Gynecol 119 263\u2013269. (https:\/\/doi.org\/10.1097\/aog.0b013e31823f7135)"},{"key":"bib7","series-title":"Hum Reprod","first-page":"1075","article-title":"High prevalence of moderate and severe depressive and anxiety symptoms in polycystic ovary syndrome: a systematic review and meta-analysis","volume":"32","author":"Cooney LG","year":"2017","unstructured":"Cooney LG\n, \nLee I\n, \nSammel MD\n, et al.\n 2017 High prevalence of moderate and severe depressive and anxiety symptoms in polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod 32 1075\u20131091. (https:\/\/doi.org\/10.1093\/humrep\/dex044)"},{"key":"bib8","series-title":"Fertil Steril","first-page":"1444","article-title":"Cardiovascular and metabolic profiles amongst different polycystic ovary syndrome phenotypes: who is really at risk?","volume":"102","author":"Daan NM","year":"2014","unstructured":"Daan NM\n, \nLouwers YV\n, \nKoster MP\n, et al.\n 2014 Cardiovascular and metabolic profiles amongst different polycystic ovary syndrome phenotypes: who is really at risk? Fertil Steril 102 1444\u20131451 e3. (https:\/\/doi.org\/10.1016\/j.fertnstert.2014.08.001)"},{"key":"bib9","series-title":"BMC Med","first-page":"151","article-title":"Back to the basics of ovarian aging: a population-based study on longitudinal anti-Mullerian hormone decline","volume":"14","author":"de Kat AC","year":"2016","unstructured":"de Kat AC\n, \nVan Der Schouw YT\n, \nEijkemans MJ\n, et al.\n 2016 Back to the basics of ovarian aging: a population-based study on longitudinal anti-Mullerian hormone decline. BMC Med 14 151. (https:\/\/doi.org\/10.1186\/s12916-016-0699-y)"},{"key":"bib10","series-title":"Fertil Steril","first-page":"885","article-title":"Heart health in polycystic ovary syndrome: time to act on the data","volume":"117","author":"Dokras A","year":"2022","unstructured":"Dokras A\n\n 2022 Heart health in polycystic ovary syndrome: time to act on the data. Fertil Steril 117 885\u2013886. (https:\/\/doi.org\/10.1016\/j.fertnstert.2022.03.014)"},{"key":"bib11","series-title":"Nat Rev Endocrinol","first-page":"10","article-title":"Reproductive endocrinology: menstrual dysfunction \u2013 a proxy for insulin resistance in PCOS?","volume":"10","author":"Escobar-Morreale HF","year":"2014","unstructured":"Escobar-Morreale HF\n\n 2014 Reproductive endocrinology: menstrual dysfunction \u2013 a proxy for insulin resistance in PCOS? Nat Rev Endocrinol 10 10\u201311. (https:\/\/doi.org\/10.1038\/nrendo.2013.232)"},{"key":"bib12","series-title":"Nat Rev Endocrinologyl","first-page":"270","article-title":"Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment","volume":"14","author":"Escobar-Morreale HF","year":"2018","unstructured":"Escobar-Morreale HF\n\n 2018 Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinologyl 14 270\u2013284. (https:\/\/doi.org\/10.1038\/nrendo.2018.24)"},{"key":"bib15","series-title":"Trends Endocrinol Metab","first-page":"266","article-title":"Abdominal adiposity and the polycystic ovary syndrome","volume":"18","author":"Escobar-Morreale HF","year":"2007","unstructured":"Escobar-Morreale HF\n & \nMill\u00e1n JLS\n\n 2007 Abdominal adiposity and the polycystic ovary syndrome. Trends Endocrinol Metab 18 266\u2013272. (https:\/\/doi.org\/10.1016\/j.tem.2007.07.003)"},{"key":"bib13","series-title":"Diabetes Care","first-page":"2042","article-title":"Body iron stores are increased in overweight and obese women with polycystic ovary syndrome","volume":"28","author":"Escobar-Morreale HF","year":"2005a","unstructured":"Escobar-Morreale HF\n, \nLuque-Ramirez M\n, \nAlvarez-Blasco F\n, et al.\n 2005a Body iron stores are increased in overweight and obese women with polycystic ovary syndrome. Diabetes Care 28 2042\u20132044. (https:\/\/doi.org\/10.2337\/diacare.28.8.2042)"},{"key":"bib14","series-title":"Endocr Rev","first-page":"251","article-title":"The molecular-genetic basis of functional hyperandrogenism and the polycystic ovary syndrome","volume":"26","author":"Escobar-Morreale HF","year":"2005b","unstructured":"Escobar-Morreale HF\n, \nLuque-Ramirez M\n & \nSan Millan JL\n\n 2005b The molecular-genetic basis of functional hyperandrogenism and the polycystic ovary syndrome. Endocr Rev 26 251\u2013282. (https:\/\/doi.org\/10.1210\/er.2004-0004)"},{"key":"bib16","series-title":"Hum Reprod Update","first-page":"390","article-title":"Prevalence of \u2018obesity-associated gonadal dysfunction\u2019 in severely obese men and women and its resolution after bariatric surgery: a systematic review and meta-analysis","volume":"23","author":"Escobar-Morreale HF","year":"2017","unstructured":"Escobar-Morreale HF\n, \nSantacruz E\n, \nLuque-Ramirez M\n, et al.\n 2017 Prevalence of \u2018obesity-associated gonadal dysfunction\u2019 in severely obese men and women and its resolution after bariatric surgery: a systematic review and meta-analysis. Hum Reprod Update 23 390\u2013408. (https:\/\/doi.org\/10.1093\/humupd\/dmx012)"},{"key":"bib17","series-title":"Int J Obes Relat Metab Disord","first-page":"883","article-title":"Obesity and the polycystic ovary syndrome","volume":"26","author":"Gambineri A","year":"2002","unstructured":"Gambineri A\n, \nPelusi C\n, \nVicennati V\n, et al.\n 2002 Obesity and the polycystic ovary syndrome. Int J Obes Relat Metab Disord 26 883\u2013896."},{"key":"bib18","series-title":"J Clin Endocrinol Metab","first-page":"3970","article-title":"Treatment with flutamide, metformin, and their combination added to a hypocaloric diet in overweight-obese women with polycystic ovary syndrome: a randomized, 12-month, placebo-controlled study","volume":"91","author":"Gambineri A","year":"2006","unstructured":"Gambineri A\n, \nPatton L\n, \nVaccina A\n, et al.\n 2006 Treatment with flutamide, metformin, and their combination added to a hypocaloric diet in overweight-obese women with polycystic ovary syndrome: a randomized, 12-month, placebo-controlled study. J Clin Endocrinol Metab 91 3970\u20133980. (https:\/\/doi.org\/10.1210\/jc.2005-2250)"},{"key":"bib19","series-title":"Eur J Endocrinol","first-page":"210","article-title":"Evolution of cardiovascular risk factors and the risk for cardiovascular events in a Caucasian population with polycystic ovary syndrome","volume":"192","author":"Gambineri A","year":"2025","unstructured":"Gambineri A\n, \nRosa S\n, \nPandurevic S\n, et al.\n 2025 Evolution of cardiovascular risk factors and the risk for cardiovascular events in a Caucasian population with polycystic ovary syndrome. Eur J Endocrinol 192 210\u2013219. (https:\/\/doi.org\/10.1093\/ejendo\/lvaf027)"},{"key":"bib20","series-title":"J Clin Endocrinol Metab","first-page":"2809","article-title":"Depression over the lifespan in a population-based cohort of women with polycystic ovary syndrome: longitudinal analysis","volume":"104","author":"Greenwood EA","year":"2019","unstructured":"Greenwood EA\n, \nYaffe K\n, \nWellons MF\n, et al.\n 2019 Depression over the lifespan in a population-based cohort of women with polycystic ovary syndrome: longitudinal analysis. J Clin Endocrinol Metab 104 2809\u20132819. (https:\/\/doi.org\/10.1210\/jc.2019-00234)"},{"key":"bib21","series-title":"Fertil Steril","first-page":"843","article-title":"Executive summary of the stages of reproductive aging workshop + 10: addressing the unfinished agenda of staging reproductive aging","volume":"97","author":"Harlow SD","year":"2012","unstructured":"Harlow SD\n, \nGass M\n, \nHall JE\n, et al.\n 2012 Executive summary of the stages of reproductive aging workshop + 10: addressing the unfinished agenda of staging reproductive aging. Fertil Steril 97 843\u2013851. (https:\/\/doi.org\/10.1016\/j.fertnstert.2012.01.128)"},{"key":"bib22","series-title":"PLoS One","article-title":"Risk of psychiatric disorders following polycystic ovary syndrome: a nationwide population-based cohort study","volume":"9","author":"Hung JH","year":"2014","unstructured":"Hung JH\n, \nHu LY\n, \nTsai SJ\n, et al.\n 2014 Risk of psychiatric disorders following polycystic ovary syndrome: a nationwide population-based cohort study. PLoS One 9 e97041. (https:\/\/doi.org\/10.1371\/journal.pone.0097041)"},{"key":"bib23","series-title":"Hum Reprod Update","first-page":"455","article-title":"Ethnicity, obesity and the prevalence of impaired glucose tolerance and type 2 diabetes in PCOS: a systematic review and meta-regression","volume":"24","author":"Kakoly NS","year":"2018","unstructured":"Kakoly NS\n, \nKhomami MB\n, \nJoham AE\n, et al.\n 2018 Ethnicity, obesity and the prevalence of impaired glucose tolerance and type 2 diabetes in PCOS: a systematic review and meta-regression. Hum Reprod Update 24 455\u2013467. (https:\/\/doi.org\/10.1093\/humupd\/dmy007)"},{"key":"bib24","series-title":"J Clin Endocrinol Metab","first-page":"1861","article-title":"Psychological distress is more prevalent in fertile age and premenopausal women with PCOS symptoms: 15-year follow-up","volume":"102","author":"Karjula S","year":"2017","unstructured":"Karjula S\n, \nMorin-Papunen L\n, \nAuvinen J\n, et al.\n 2017 Psychological distress is more prevalent in fertile age and premenopausal women with PCOS symptoms: 15-year follow-up. J Clin Endocrinol Metab 102 1861\u20131869. (https:\/\/doi.org\/10.1210\/jc.2016-3863)"},{"key":"bib25","series-title":"J Clin Endocrinol Metab","first-page":"1814","article-title":"Population-based data at ages 31 and 46 show decreased HRQoL and life satisfaction in women with PCOS symptoms","volume":"105","author":"Karjula S","year":"2020","unstructured":"Karjula S\n, \nMorin-Papunen L\n, \nFranks S\n, et al.\n 2020 Population-based data at ages 31 and 46 show decreased HRQoL and life satisfaction in women with PCOS symptoms. J Clin Endocrinol Metab 105 1814\u20131826. (https:\/\/doi.org\/10.1210\/clinem\/dgz256)"},{"key":"bib26","series-title":"J Clin Endocrinol Metab","first-page":"e750","article-title":"Depression, anxiety, and risk of metabolic syndrome in women with polycystic ovary syndrome: a longitudinal study","volume":"110","author":"Lee IT","year":"2025","unstructured":"Lee IT\n, \nRees J\n, \nKing S\n, et al.\n 2025 Depression, anxiety, and risk of metabolic syndrome in women with polycystic ovary syndrome: a longitudinal study. J Clin Endocrinol Metab 110 e750\u2013e756. (https:\/\/doi.org\/10.1210\/clinem\/dgae256)"},{"key":"bib27","series-title":"Cochrane Database Syst Rev","article-title":"Lifestyle changes in women with polycystic ovary syndrome","volume":"3","author":"Lim SS","year":"2019","unstructured":"Lim SS\n, \nHutchison SK\n, \nVan Ryswyk E\n, et al.\n 2019 Lifestyle changes in women with polycystic ovary syndrome. Cochrane Database Syst Rev 3 CD007506. (https:\/\/doi.org\/10.1002\/14651858.cd007506.pub4)"},{"key":"bib28","series-title":"Hum Reprod Update","first-page":"741","article-title":"PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis","volume":"29","author":"Millan-De-Meer M","year":"2023","unstructured":"Millan-De-Meer M\n, \nLuque-Ramirez M\n, \nNattero-Chavez L\n, et al.\n 2023 PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis. Hum Reprod Update 29 741\u2013772. (https:\/\/doi.org\/10.1093\/humupd\/dmad015)"},{"key":"bib29","series-title":"J Clin Endocrinol Metab","first-page":"139","article-title":"Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: a randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation","volume":"85","author":"Moghetti P","year":"2000","unstructured":"Moghetti P\n, \nCastello R\n, \nNegri C\n, et al.\n 2000 Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: a randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation. J Clin Endocrinol Metab 85 139\u2013146. (https:\/\/doi.org\/10.1210\/jcem.85.1.6293)"},{"key":"bib30","series-title":"Hum Reprod","first-page":"86","article-title":"Clinical presentation of PCOS following development of an insulinoma: case report","volume":"15","author":"Murray RD","year":"2000","unstructured":"Murray RD\n, \nDavison RM\n, \nRussell RC\n, et al.\n 2000 Clinical presentation of PCOS following development of an insulinoma: case report. Hum Reprod 15 86\u201388. (https:\/\/doi.org\/10.1093\/humrep\/15.1.86)"},{"key":"bib31","series-title":"Eur J Endocrinol","first-page":"96","article-title":"Women with PCOS have an increased risk for cardiovascular disease regardless of diagnostic criteria-a prospective population-based cohort study","volume":"189","author":"Ollila MM","year":"2023","unstructured":"Ollila MM\n, \nArffman RK\n, \nKorhonen E\n, et al.\n 2023 Women with PCOS have an increased risk for cardiovascular disease regardless of diagnostic criteria-a prospective population-based cohort study. Eur J Endocrinol 189 96\u2013105. (https:\/\/doi.org\/10.1093\/ejendo\/lvad077)"},{"key":"bib32","series-title":"J Wom Health","first-page":"762","article-title":"A systematic review and meta-analysis of the association between polycystic ovary syndrome and coronary artery calcification","volume":"31","author":"Osibogun O","year":"2022","unstructured":"Osibogun O\n, \nOgunmoroti O\n, \nKolade OB\n, et al.\n 2022 A systematic review and meta-analysis of the association between polycystic ovary syndrome and coronary artery calcification. J Wom Health 31 762\u2013771. (https:\/\/doi.org\/10.1089\/jwh.2021.0608)"},{"key":"bib33","series-title":"Diabetes Care","first-page":"1050","article-title":"Prevalence of polycystic ovary syndrome among premenopausal women with type 2 diabetes","volume":"24","author":"Peppard HR","year":"2001","unstructured":"Peppard HR\n, \nMarfori J\n, \nIuorno MJ\n, et al.\n 2001 Prevalence of polycystic ovary syndrome among premenopausal women with type 2 diabetes. Diabetes Care 24 1050\u20131052. (https:\/\/doi.org\/10.2337\/diacare.24.6.1050)"},{"key":"bib34","series-title":"J Clin Endocrinol Metab","first-page":"3400","article-title":"Androgen profile through life in women with polycystic ovary syndrome: a nordic multicenter collaboration study","volume":"100","author":"Pinola P","year":"2015","unstructured":"Pinola P\n, \nPiltonen TT\n, \nPuurunen J\n, et al.\n 2015 Androgen profile through life in women with polycystic ovary syndrome: a nordic multicenter collaboration study. J Clin Endocrinol Metab 100 3400\u20133407. (https:\/\/doi.org\/10.1210\/jc.2015-2123)"},{"key":"bib35","series-title":"Hum Reprod","first-page":"1003","article-title":"Amelioration of insulin resistance in women with PCOS via reduced insulin receptor substrate-1 Ser312 phosphorylation following laparoscopic ovarian electrocautery","volume":"22","author":"Seow K-M","year":"2007","unstructured":"Seow K-M\n, \nJuan C-C\n, \nHsu Y-P\n, et al.\n 2007 Amelioration of insulin resistance in women with PCOS via reduced insulin receptor substrate-1 Ser312 phosphorylation following laparoscopic ovarian electrocautery. Hum Reprod 22 1003\u20131010. (https:\/\/doi.org\/10.1093\/humrep\/del466)"},{"key":"bib36","series-title":"J Intern Med","first-page":"484","article-title":"Insulinoma presenting with hyperandrogenism: a case report and a literature review","volume":"253","author":"Stanciu IN","year":"2003","unstructured":"Stanciu IN\n, \nPitale S\n, \nPrinz RA\n, et al.\n 2003 Insulinoma presenting with hyperandrogenism: a case report and a literature review. J Intern Med 253 484\u2013489. (https:\/\/doi.org\/10.1046\/j.1365-2796.2003.01132.x)"},{"key":"bib37","series-title":"J Am Heart Assoc","article-title":"2023 international evidence-based polycystic ovary syndrome guideline update: insights from a systematic review and meta-analysis on elevated clinical cardiovascular disease in polycystic ovary syndrome","volume":"13","author":"Tay CT","year":"2024","unstructured":"Tay CT\n, \nMousa A\n, \nVyas A\n, et al.\n 2024 2023 international evidence-based polycystic ovary syndrome guideline update: insights from a systematic review and meta-analysis on elevated clinical cardiovascular disease in polycystic ovary syndrome. J Am Heart Assoc 13 e033572. (https:\/\/doi.org\/10.1161\/jaha.123.033572)"},{"key":"bib38","series-title":"Hum Reprod","first-page":"1655","article-title":"Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"38","author":"Teede HJ","year":"2023","unstructured":"Teede HJ\n, \nTay CT\n, \nLaven J\n, et al.\n 2023 Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Hum Reprod 38 1655\u20131679. (https:\/\/doi.org\/10.1093\/humrep\/dead156)"},{"key":"bib39","series-title":"Trends Endocrinol Metab","first-page":"65","article-title":"Human ovarian theca cells in culture","volume":"17","author":"Wickenheisser JK","year":"2006","unstructured":"Wickenheisser JK\n, \nNelson-Degrave VL\n & \nMcallister JM\n\n 2006 Human ovarian theca cells in culture. Trends Endocrinol Metab 17 65\u201371. (https:\/\/doi.org\/10.1016\/j.tem.2006.01.003)"},{"key":"bib40","series-title":"J Clin Endocrinol Metab","first-page":"2038","article-title":"Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the androgen excess and polycystic ovary syndrome (AE-PCOS) society","volume":"95","author":"Wild RA","year":"2010","unstructured":"Wild RA\n, \nCarmina E\n, \nDiamanti-Kandarakis E\n, et al.\n 2010 Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the androgen excess and polycystic ovary syndrome (AE-PCOS) society. J Clin Endocrinol Metab 95 2038\u20132049. (https:\/\/doi.org\/10.1210\/jc.2009-2724)"},{"key":"bib41","series-title":"Fertil Steril","article-title":"Lipid levels in polycystic ovary syndrome: systematic review and meta-analysis","volume":"95","author":"Wild RA","year":"2011","unstructured":"Wild RA\n, \nRizzo M\n, \nClifton S\n, et al.\n 2011 Lipid levels in polycystic ovary syndrome: systematic review and meta-analysis. Fertil Steril 95 1073-9 e1-11. (https:\/\/doi.org\/10.1016\/j.fertnstert.2010.12.027)"},{"key":"bib42","series-title":"J Clin Endocrinol Metab","first-page":"302","article-title":"Modulation by insulin of follicle-stimulating hormone and luteinizing hormone actions in human granulosa cells of normal and polycystic ovaries","volume":"81","author":"Willis D","year":"1996","unstructured":"Willis D\n, \nMason H\n, \nGillingsmith C\n, et al.\n 1996 Modulation by insulin of follicle-stimulating hormone and luteinizing hormone actions in human granulosa cells of normal and polycystic ovaries. J Clin Endocrinol Metab 81 302\u2013309. 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