{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:14:20Z","timestamp":1789733660584,"version":"4.0.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"2","funder":[{"name":"Shandong Postdoctoral Science Foundation, China","award":["SDCX-ZG-202303066"],"award-info":[{"award-number":["SDCX-ZG-202303066"]}]},{"name":"Shandong Provincial Natural Science Foundation, China","award":["ZR2020MH068"],"award-info":[{"award-number":["ZR2020MH068"]}]}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7,7]]},"abstract":"<jats:sec>\n                    <jats:title>In brief<\/jats:title>\n                    <jats:p>There is no ideal animal model of adenomyosis, which reflects the imperfect understanding of complex human pathogenesis. In this study, we successfully induced adenomyosis in a mouse model via sharp-blunt trauma, which more closely mimics clinical observations in humans than previous models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Adenomyosis is a common gynecological disease in women of reproductive. To date, a satisfactory animal model of adenomyosis has not been established. In this study, 51 female mice were divided into four groups: negative control, an abdominal skin incision was made and sutured without uterine injury; puncture, the uterine horn was punctured using a needle; dilation &amp; curettage, a self-made curette was used to simulate D&amp;C; puncture + dilation &amp; curettage, the uterine horn was punctured, and dilation &amp; curettage were performed. The mice were euthanized 2 weeks, 1 month, or 2 months post-surgery, and the uteruses were harvested. Validity was assessed by histopathological examination. The levels of EMT markers were also detected among the groups. The success rate of adenomyosis induction was higher in the Punct + D&amp;C group than in other groups at all three time points. The highest success rate was observed in the Punct + D&amp;C group 2 months post-surgery. Significantly increased VIM expression was observed in ectopic lesions compared with eutopic endometrium in the Punct + D&amp;C group 2 weeks post-surgery. In addition, VIM expression in eutopic endometrium in the Punct + D&amp;C group was significantly higher than that in the sham group 2 months post-surgery. CDH1 expression was downregulated in the Punct + D&amp;C group compared with the sham group at 2 weeks and 2 months post-surgery. In this study, we successfully established a mouse model of adenomyosis based on invagination theory, which is low cost, quick to establish, and does not interfere with hormone secretion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/rep-25-0158","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T11:22:04Z","timestamp":1751887324000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of three modified mouse models of adenomyosis based on invagination theory"],"prefix":"10.1093","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0677-5427","authenticated-orcid":true,"given":"Song","family":"Guo","sequence":"first","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine, Jinan, China"},{"name":"Department of Obstetrics and Gynecology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shandong Provincial Third Hospital, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Guo","sequence":"additional","affiliation":[{"name":"Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China"},{"name":"Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxia","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China"},{"name":"Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuewen","family":"Zhao","sequence":"additional","affiliation":[{"name":"CReATe Fertility Centre, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Reproduction and Genetics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"bib1","series-title":"Vet Pathol","first-page":"572","article-title":"Endometrial hyperplasia, polyps, and adenomyosis associated with unopposed estrogen in rhesus monkeys (Macaca mulatta)","volume":"39","author":"Baskin GB","year":"2002","unstructured":"Baskin GB\n, \nSmith SM\n & \nMarx PA\n\n 2002 Endometrial hyperplasia, polyps, and adenomyosis associated with unopposed estrogen in rhesus monkeys (Macaca mulatta). 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