{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T01:10:07Z","timestamp":1769908207516,"version":"3.49.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7,11]]},"abstract":"<jats:sec>\n                    <jats:title>In brief<\/jats:title>\n                    <jats:p>\n                      Elephants have an expanded family of\n                      <jats:italic>TP53<\/jats:italic>\n                      retrogenes that have been interpreted as an anti-cancer adaptation. This point of view suggests an alternative explanation and argues that reproduction is often sidelined in discussions of pleiotropic gene function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Expansion of the elephant\n                      <jats:italic>TP53<\/jats:italic>\n                      retrogene family has been proposed to contribute to cancer prevention in this large, long-lived species, consistent with Peto\u2019s paradox. However, the P53 protein acts in several physiological contexts, and the exclusive focus on cancer exemplifies the marginalisation of reproduction in studies of pleiotropic gene function.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/rep-25-0254","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T18:09:00Z","timestamp":1752516540000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":1,"title":["Peto\u2019s paradox and elephant TP53 retrogenes: cancer or reproduction?"],"prefix":"10.1093","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9712-9625","authenticated-orcid":true,"given":"Tom","family":"Moore","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"bib1","series-title":"JAMA","first-page":"1850","article-title":"Potential mechanisms for cancer resistance in elephants and comparative cellular response to DNA damage in humans","volume":"314","author":"Abegglen LM","year":"2015","unstructured":"Abegglen LM\n, \nCaulin AF\n, \nChan A\n, et al.\n 2015 Potential mechanisms for cancer resistance in elephants and comparative cellular response to DNA damage in humans. 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