{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T02:09:25Z","timestamp":1767838165162,"version":"3.49.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Histological and steroidogenic changes within dominant ovarian follicles (DFs) undergoing atresia following systemic administration of oestradiol benzoate (ODB) were characterized in beef heifers. At 5.6 \u00b1 0.1 days after the onset of oestrus, heifers received 1 mg ODB i.m.\/500 kg body weight (ODB; n = 15) or served as controls (n = 15). Timing of treatment initiation was designated as hour (h) 0 on day (d) 0, and coincided with the presence of the DF of the first follicular wave (DF1). Within treatments, the DF1 was collected following ovariectomy in four animals at h 12, h 36 or after ultrasonic detection of a new wave (NW) of ovarian follicular development. In heifers of the NW groups (n = 7 per treatment), blood samples were collected at intervals of 20 min for 12 h beginning at h \u2212 12, 0, 24 and 48 to characterize circulating LH patterns. Administration of ODB suppressed (P &amp;lt; 0.01) mean concentrations of LH at h 24 and h 48 by preventing (P &amp;lt; 0.05) the increase in LH pulse amplitude observed in controls, but had no effect on FSH. Follicular fluid (FF) concentrations of androgens and oestradiol were reduced at h 36 in the ODB-treated group. The diameter of the DF1 and the number of granulosa cell layers were also reduced in ODB-treated as compared with control heifers. Treatment differences were not observed in the proportion of apoptotic granulosa cells as assessed using the TUNEL assay method, and timing of a new wave of follicular development (d 4.6 \u00b1 0.2) was similar (P &amp;gt; 0.1) among treatments. A prominent characteristic of oestradiol-induced atresia of the DF1 of the oestrous cycle in heifers was a loss in oestrogenic function associated with reduced LH support. However, the timing of new follicular development may be influenced by a factor(s) other than the status of the DF undergoing oestradiol-induced atresia.<\/jats:p>","DOI":"10.1530\/rep.1.00384","type":"journal-article","created":{"date-parts":[[2005,4,26]],"date-time":"2005-04-26T17:18:29Z","timestamp":1114535909000},"page":"611-620","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":11,"title":["Histological and steroidogenic changes in dominant ovarian follicles during oestradiol-induced atresia in heifers"],"prefix":"10.1093","volume":"129","author":[{"given":"Christopher R","family":"Burke","sequence":"first","affiliation":[{"name":"Department of Animal Sciences, The Ohio State University, Columbus, Ohio 43210, USA"},{"name":"Dexcel Ltd, Private Bag 3221, Hamilton, New 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