{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:26:30Z","timestamp":1771028790427,"version":"3.50.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Little is known about the first meiotic prophase stages in the human female because these occur during fetal life, and only a few studies have addressed aneuploid human oocytes. In this paper, the synaptic process in the meiotic prophase in three 47, XX + 18 cases is analyzed. A complete study of the dynamics of centromeres and telomeres, cohesin core and synapsis development in aneuploid female meiosis was performed. Investigation of chromosome dynamics in prophase of trisomy 18 oocytes show that these events follow the major patterns seen earlier in euploid oocytes. However, there is a significant delay in the resolution of bouquet topology which could relate to the presence of a surplus chromosome 18 axial element in zygotene oocytes. Pachytene oocytes displayed normal synapsis among the three chromosome 18s. However, in some oocytes the surplus chromosome 18 core was aligned to the bivalent 18. As ataxia telangiectasia and Rad3 related kinase (ATR) has been described as a marker for late-pairing chromosomes in mice, ATR distribution was analyzed in human meiocytes \u2013spermatocytes, euploid oocytes and trisomic oocytes. In contrast to the observations made in mice, no preferential staining for late-pairing chromosomes was observed in humans. In the cases studied, bivalent synapses progressed as in a normal ovary, contrasting with the hypothesis that a surplus chromosome can modify pairing of other chromosomes.<\/jats:p>","DOI":"10.1530\/rep.1.00568","type":"journal-article","created":{"date-parts":[[2005,4,26]],"date-time":"2005-04-26T17:18:29Z","timestamp":1114535909000},"page":"565-575","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":13,"title":["Chromosome 18 pairing behavior in human trisomic oocytes. Presence of an extra chromosome extends bouquet stage"],"prefix":"10.1093","volume":"129","author":[{"given":"I","family":"Roig","sequence":"first","affiliation":[{"name":"Departament de Biologia Cellular, Fisiologia i Immunologia, Universitat Auto\u0300noma de Barcelona, 08193-Bellaterra, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Robles","sequence":"additional","affiliation":[{"name":"Departament de Biologia Cellular, Fisiologia i Immunologia, Universitat Auto\u0300noma de Barcelona, 08193-Bellaterra, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Garcia","sequence":"additional","affiliation":[{"name":"Departament de Biologia Cellular, Fisiologia i Immunologia, Universitat Auto\u0300noma de Barcelona, 08193-Bellaterra, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Marti\u0301nez-Flores","sequence":"additional","affiliation":[{"name":"Departament de Biologia Cellular, Fisiologia i Immunologia, Universitat Auto\u0300noma de Barcelona, 08193-Bellaterra, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ll","family":"Cabero","sequence":"additional","affiliation":[{"name":"Servei de Ginecologia i Obstetri\u0301cia, Hospital Materno-infantil de la Vall d\u2019Hebron, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Egozcue","sequence":"additional","affiliation":[{"name":"Departament de Biologia Cellular, Fisiologia i Immunologia, Universitat Auto\u0300noma de Barcelona, 08193-Bellaterra, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Liebe","sequence":"additional","affiliation":[{"name":"Max-Planck-Institute for Molecular Genetics, Ihnestrasse 73, D-14195 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Scherthan","sequence":"additional","affiliation":[{"name":"Max-Planck-Institute for Molecular Genetics, Ihnestrasse 73, D-14195 Berlin, Germany"},{"name":"Institute of Radiation Biology Bw Neuherbergstr. 1180937, Mu\u0308nchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Garcia","sequence":"additional","affiliation":[{"name":"Departament de Biologia Cellular, Fisiologia i Immunologia, Universitat Auto\u0300noma de Barcelona, 08193-Bellaterra, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,5,1]]},"reference":[{"key":"2026010713011803200_BAART-ETAL-2000","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s004120050422","volume":"109","year":"2000","journal-title":"Chromosoma"},{"key":"2026010713011803200_BARLOW-AND-HULTEN-1997","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s004120050250","volume":"106","year":"1997","journal-title":"Chromosoma"},{"key":"2026010713011803200_BARLOW-ETAL-2002","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000063045","volume":"96","year":"2002","journal-title":"Cytogenetics and Genome Research"},{"key":"2026010713011803200_BOJKO-1983","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/BF02911920","volume":"48","year":"1983","journal-title":"Carlsberg Research Communications"},{"key":"2026010713011803200_CHENG-ETAL-1995","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1159\/000134034","volume":"70","year":"1995","journal-title":"Cytogenetics and Cell Genetics"},{"key":"2026010713011803200_CHENG-ETAL-1998","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1159\/000014956","volume":"80","year":"1998","journal-title":"Cytogenetics and Cell Genetics"},{"key":"2026010713011803200_COHEN-AND-POLLARD-2001","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1002\/bies.1145","volume":"23","year":"2001","journal-title":"Bioessays"},{"key":"2026010713011803200_EIJPE-ETAL-2000","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1242\/jcs.113.4.673","volume":"113","year":"2000","journal-title":"Journal of Cell Science"},{"key":"2026010713011803200_EIJPE-ETAL-2003","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1083\/jcb.200212080","volume":"160","year":"2003","journal-title":"Journal of Cell Biology"},{"key":"2026010713011803200_FAWCETT-1956","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1083\/jcb.2.4.403","volume":"2","year":"1956","journal-title":"Journal of Biophysical and Biochemical Cytology"},{"key":"2026010713011803200_GARCIA-ETAL-1987","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF00284474","volume":"77","year":"1987","journal-title":"Human Genetics"},{"key":"2026010713011803200_HARPER-ETAL-2004","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.1242\/jcs.01363","volume":"117","year":"2004","journal-title":"Journal of Cell Science"},{"key":"2026010713011803200_HASSOLD-AND-HUNT-2001","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/35066065","volume":"2","year":"2001","journal-title":"Nature Reviews. Genetics"},{"key":"2026010713011803200_HEYTING-1996","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0955-0674(96)80015-9","volume":"8","year":"1996","journal-title":"Current Opinion in Cell Biology"},{"key":"2026010713011803200_KEEGAN-ETAL-1996","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1101\/gad.10.19.2423","volume":"10","year":"1996","journal-title":"Genes and Development"},{"key":"2026010713011803200_KIM-ETAL-1999","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/70508","volume":"23","year":"1999","journal-title":"Nature Genetics"},{"key":"2026010713011803200_LAMMERS-ETAL-1994","first-page":"1137","volume":"14","year":"1994","journal-title":"Molecular and Cellular Biology"},{"key":"2026010713011803200_LENZI-ETAL-2005","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1086\/427268","volume":"76","year":"2005","journal-title":"American Journal of Human Genetics"},{"key":"2026010713011803200_LOIDL-1990","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1139\/g90-115","volume":"33","year":"1990","journal-title":"Genome"},{"key":"2026010713011803200_LUCIANI-ETAL-1976","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF00292913","volume":"57","year":"1976","journal-title":"Chromosoma"},{"key":"2026010713011803200_MAHADEVAIAH-ETAL-2001","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/85830","volume":"27","year":"2001","journal-title":"Nature Genetics"},{"key":"2026010713011803200_MARTINEZ-FLORES-ETAL-2001","first-page":"701","volume":"16","year":"2001","journal-title":"Histology and Histopathology"},{"key":"2026010713011803200_MARTINEZ-FLORES-ETAL-2003","first-page":"450","volume":"60","year":"2003","journal-title":"Microscopy: Research Techniques"},{"key":"2026010713011803200_MEUWISSEN-ETAL-1992","doi-asserted-by":"crossref","first-page":"5091","DOI":"10.1002\/j.1460-2075.1992.tb05616.x","volume":"11","year":"1992","journal-title":"EMBO Journal"},{"key":"2026010713011803200_MOENS-ETAL-1999","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s004120050356","volume":"108","year":"1999","journal-title":"Chromosoma"},{"key":"2026010713011803200_MOENS-ETAL-2001","first-page":"1611","volume":"115","year":"2001","journal-title":"Journal of Cell Science"},{"key":"2026010713011803200_MOSES-1968","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1146\/annurev.ge.02.120168.002051","volume":"2","year":"1968","journal-title":"Annual Review of Genetics"},{"key":"2026010713011803200_OFFENBERG-ETAL-1998","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1093\/nar\/26.11.2572","volume":"26","year":"1998","journal-title":"Nucleic Acids Research"},{"key":"2026010713011803200_PELTTARI-ETAL-2001","doi-asserted-by":"crossref","first-page":"5667","DOI":"10.1128\/MCB.21.16.5667-5677.2001","volume":"21","year":"2001","journal-title":"Molecular and Cellular Biology"},{"key":"2026010713011803200_PERERA-ETAL-2004","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1091\/mbc.e03-06-0444","volume":"15","year":"2004","journal-title":"Molecular Biology of the Cell"},{"key":"2026010713011803200_PEZZI-ETAL-2000","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1096\/fasebj.14.3.581","volume":"14","year":"2000","journal-title":"FASEB Journal"},{"key":"2026010713011803200_PFEIFER-ETAL-2001","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1159\/000057002","volume":"93","year":"2001","journal-title":"Cytogenetics and Cell Genetics"},{"key":"2026010713011803200_PFEIFER-ETAL-2003","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0012-1606(02)00093-3","volume":"255","year":"2003","journal-title":"Developmental Biology"},{"key":"2026010713011803200_PRIETO-ETAL-2001","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/35087082","volume":"3","year":"2001","journal-title":"Nature Cell Biology"},{"key":"2026010713011803200_PRIETO-ETAL-2002","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/embo-reports\/kvf108","volume":"3","year":"2002","journal-title":"EMBO Reports"},{"key":"2026010713011803200_PRIETO-ETAL-2004","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1023\/B:CHRO.0000021945.83198.0e","volume":"12","year":"2004","journal-title":"Chromosome Research"},{"key":"2026010713011803200_ROCKMILL-AND-ROEDER-1998","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1101\/gad.12.16.2574","volume":"12","year":"1998","journal-title":"Genes and Development"},{"key":"2026010713011803200_RODRIGUEZ-AND-BURGOYNE-2000","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1159\/000015559","volume":"89","year":"2000","journal-title":"Cytogenetics and Genome Research"},{"key":"2026010713011803200_ROEDER-AND-BAILIS-2000","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0168-9525(00)02080-1","volume":"16","year":"2000","journal-title":"Trends in Genetics"},{"key":"2026010713011803200_ROIG-ETAL-2003","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1023\/A:1024228932488","volume":"41","year":"2003","journal-title":"Cytotechnology"},{"key":"2026010713011803200_ROIG-ETAL-2004","first-page":"22","volume":"113","year":"2004","journal-title":"Chromosoma"},{"key":"2026010713011803200_SCHERTHAN-2001","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/35085086","volume":"2","year":"2001","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"2026010713011803200_SCHERTHAN-2003","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1159\/000076809","volume":"103","year":"2003","journal-title":"Cytogenetics and Genome Research"},{"key":"2026010713011803200_SCHERTHAN-ETAL-1996","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1083\/jcb.134.5.1109","volume":"134","year":"1996","journal-title":"Journal of Cell Biology"},{"key":"2026010713011803200_SCHMEKEL-AND-DANEHOLT-1995","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0962-8924(00)89017-0","volume":"5","year":"1995","journal-title":"Trends in Cell Biology"},{"key":"2026010713011803200_SOLARI-1980","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/BF00368145","volume":"81","year":"1980","journal-title":"Chromosoma"},{"key":"2026010713011803200_SPEED-1984","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/BF00286596","volume":"66","year":"1984","journal-title":"Human Genetics"},{"key":"2026010713011803200_WALLACE-AND-HULTEN-1983","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1469-1809.1983.tb00996.x","volume":"47","year":"1983","journal-title":"Annals of Human Genetics"},{"key":"2026010713011803200_WEIER-ETAL-1991","first-page":"489","volume":"87","year":"1991","journal-title":"Human Genetics"}],"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rep.bioscientifica.com\/view\/journals\/rep\/129\/5\/1290565.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/129\/5\/565\/64606738\/1290565.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/129\/5\/565\/64606738\/1290565.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T18:12:04Z","timestamp":1767809524000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/129\/5\/565\/8252136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5,1]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,5,1]]}},"URL":"https:\/\/doi.org\/10.1530\/rep.1.00568","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2005,5,1]]},"published":{"date-parts":[[2005,5,1]]}}}