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A decrease in glucose transport during preimplantation development has been linked to the early steps of programmed cell death in these embryos. Decreased glucose transport is not thought to be simply a consequence of cell death, rather it is thought to be a trigger that can initiate the apoptotic cascade. Extensive apoptosis during the preimplantation period may manifest later in pregnancy as a malformation \u2013 or miscarriage, if cell loss is excessive. Phosphatidylinositol 3-kinase (PI3-K) is a known regulator of a number of physiologic responses including cellular proliferation, growth, and survival as well as glucose metabolism. Studies performed in other cell systems have demonstrated that the PI3-K pathway plays a critical role in maintaining glucose transport and metabolism. This review will present the current evidence that suggests that PI3-K is vital for preimplantation embryo survival and development. In addition, data demonstrating that PI3-K activity is important for glucose metabolism during this early developmental period will be discussed.<\/jats:p>","DOI":"10.1530\/rep.1.00645","type":"journal-article","created":{"date-parts":[[2006,5,3]],"date-time":"2006-05-03T12:59:14Z","timestamp":1146661154000},"page":"823-835","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":56,"title":["Glucose utilization and the PI3-K pathway: mechanisms for cell survival in preimplantation embryos"],"prefix":"10.1093","volume":"131","author":[{"given":"Joan K","family":"Riley","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Washington University School of Medicine, 4911 Barnes-Jewish Hospital Plaza, St Louis, Missouri 63110, USA"},{"name":"Department of Cell Biology and Physiology, Washington University School of Medicine, 4911 Barnes-Jewish Hospital Plaza, St Louis, Missouri 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelle H","family":"Moley","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Washington University School of Medicine, 4911 Barnes-Jewish Hospital Plaza, St Louis, Missouri 63110, USA"},{"name":"Department of Cell Biology and Physiology, Washington University School of Medicine, 4911 Barnes-Jewish Hospital Plaza, St Louis, Missouri 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,5,1]]},"reference":[{"key":"2026010713104094300_ADJAYE-ETAL-2005","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1634\/stemcells.2005-0113","volume":"23","year":"2005","journal-title":"Stem 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