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Fetal death was the only indication for labour induction centuries ago, while this is now a very rare indication, with prolonged pregnancy and maternal hypertensive disorders being the major indications for the last 50\u201360 years. Techniques for inducing labour have also changed from dietary delicacies and verbal threats giving way to physical stimulation mainly achieved by cervical stretching and amniotomy and more recently to sophisticated pharmacological manipulation using oxytocin and prostaglandins, based on our expanding knowledge of the physiological processes involved in spontaneous parturition. Relaxin, antiprogestins, nitric oxide as well as complementary medicines have also been explored in recent years. Successful induction is, however, still not guaranteed and there has been increasing emphasis during the past decade on exploring strategies for identifying the probability of success. Measurement of fetal fibronectin in cervical mucus, maternal serum nitrite\/nitrate concentrations, ultrasound delineation of cervical form and electrical impedance measurements across the cervix are all being investigated. Safety, success, and patient satisfaction continue to be the major objectives with economic evaluations now becoming a significant factor in the search for the ideal induction method.<\/jats:p>","DOI":"10.1530\/rep.1.00709","type":"journal-article","created":{"date-parts":[[2006,5,30]],"date-time":"2006-05-30T18:02:57Z","timestamp":1149012177000},"page":"989-998","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":65,"title":["Induction of labour at the start of the new millennium"],"prefix":"10.1093","volume":"131","author":[{"given":"I Z","family":"MacKenzie","sequence":"first","affiliation":[{"name":"Reader in Obstetrics & Gynaecology University of Oxford, John Radcliffe Hospital, Oxford, OX3 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