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The results are coherent with the mass of information which was accumulated previously, primarily on the basis of studies of selected critical factors. They highlight the activation of precise signaling pathways, some of which may have been previously under evaluated. The remodelling and maturation processes that the myometrium undergoes in pregnancy appear clearly as phenomena which last during the full course of gestation. Comparatively, the onset of labor is perhaps the phenomenon which remains the least well described by these methods of analysis. Nevertheless, genomic studies constitute a necessary first step of orientation and help establishing new links between the generic signaling pathways that are activated during the normal or pathological gestation. These studies also represent an indicative step that will have to be paralleled, in the future, with the results of the systematic proteomic analysis of the myometrium.<\/jats:p>","DOI":"10.1530\/rep.1.00725","type":"journal-article","created":{"date-parts":[[2006,5,3]],"date-time":"2006-05-03T12:59:14Z","timestamp":1146661154000},"page":"837-850","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":49,"title":["Gene and protein expression in the myometrium in pregnancy and labor"],"prefix":"10.1093","volume":"131","author":[{"given":"Michelle","family":"Breuiller-Fouche","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 767, Paris, F-75014, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Germain","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Agronomique, Biologie du 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