{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:53:10Z","timestamp":1767858790940,"version":"3.49.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The pregnancy-induced rapid degeneration of the adrenergic nerves innervating the uterus is a well-known but poorly understood phenomenon. Since most of the published investigations were carried out by histological assay, our aim was to describe the loss of the adrenergic function during pregnancy and the reinnervational procedure in the postpartum period. Myometrial and cervical samples from rats were loaded with [3H]noradrenaline and then transferred into a chamber for superfusion. After a wash-out period, fractions were collected. The fifth and fifteenth fraction tissues were stimulated with an electric field. The [3H]noradrenaline contents of the fractions were determined, together with the amount remaining in the tissue. The myometrial [3H]noradrenaline release was substantially decreased in early pregnancy, and absent in the late stage. Differences in release profile were detected between the implantation sites and the interimplantation areas. As a refinement of the results of previous histochemical studies, the noradrenergic functions of the cervix were found to be deeply affected in the early postpartum period. The pregnancy-induced denervational procedure can be followed by means of a superfusional technique after [3H]noradrenaline loading. As our technique is considered to be similar in sensitivity to histological methods, superfusion can be regarded as a model for functional investigations of pregnancy-induced denervation.<\/jats:p>","DOI":"10.1530\/rep.1.00811","type":"journal-article","created":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T15:37:48Z","timestamp":1130859468000},"page":"743-749","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":10,"title":["A rat model for functional characterization of pregnancy-induced denervation and postpartum reinnervation in the myometrium and cervix: a superfusion study"],"prefix":"10.1093","volume":"130","author":[{"given":"I","family":"Zupko\u0301","sequence":"first","affiliation":[{"name":"Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Csonka","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Falkay","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,11,1]]},"reference":[{"key":"2026010713033013100_ADHAM-AND-SCHENK-1969","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S0002-9378(16)34239-9","volume":"104","year":"1969","journal-title":"American Journal of Obstetrics & Gynecology"},{"key":"2026010713033013100_ALM-ETAL-1979","doi-asserted-by":"crossref","first-page":"C277","DOI":"10.1152\/ajpcell.1979.236.5.C277","volume":"236","year":"1979","journal-title":"American Journal of Physiology Cell Physiology"},{"key":"2026010713033013100_BELL-1972","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0031-6997(25)06932-7","volume":"24","year":"1972","journal-title":"Pharmacological Reviews"},{"key":"2026010713033013100_BELL-AND-MALCOLM-1978","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1530\/jrf.0.0530051","volume":"53","year":"1978","journal-title":"Journal of Reproduction and Fertility"},{"key":"2026010713033013100_BRAUER-ETAL-1992","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0165-1838(92)90249-G","volume":"39","year":"1992","journal-title":"Journal of the Autonomic Nervous System"},{"key":"2026010713033013100_BRAUER-ETAL-1998","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1046\/j.1469-7580.1998.19340509.x","volume":"193","year":"1998","journal-title":"Journal of Anatomy"},{"key":"2026010713033013100_BRAUER-ETAL-2000","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0165-1838(99)00094-6","volume":"79","year":"2000","journal-title":"Journal of the Autonomic Nervous System"},{"key":"2026010713033013100_BRYMAN-ETAL-1987","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000298782","volume":"24","year":"1987","journal-title":"Gynecologic and Obstetric Investigation"},{"key":"2026010713033013100_ENGSTROM-ETAL-1997","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1677\/joe.0.1530393","volume":"153","year":"1997","journal-title":"Journal of Endocrinology"},{"key":"2026010713033013100_FRIED-ETAL-1985","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1748-1716.1985.tb07593.x","volume":"123","year":"1985","journal-title":"Acta Physiologica Scandinavica"},{"key":"2026010713033013100_HAASE-ETAL-1997","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s004410050815","volume":"288","year":"1997","journal-title":"Cell & Tissue Research"},{"key":"2026010713033013100_HERVONEN-ETAL-1973","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1748-1716.1973.tb05392.x","volume":"87","year":"1973","journal-title":"Acta Physiologica Scandinavica"},{"key":"2026010713033013100_JUORIO-ETAL-1989","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/BF00964810","volume":"14","year":"1989","journal-title":"Neurochemical Research"},{"key":"2026010713033013100_KLUKOVITS-ETAL-2002","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1095\/biolreprod.101.002287","volume":"67","year":"2002","journal-title":"Biology of Reproduction"},{"key":"2026010713033013100_KORSCHING-AND-THOENEN-1983","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1073\/pnas.80.11.3513","volume":"80","year":"1983","journal-title":"PNAS"},{"key":"2026010713033013100_LEGRAND-ETAL-1993","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0022-3565(25)38303-5","volume":"266","year":"1993","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"2026010713033013100_LUNDBERG-ETAL-1987","first-page":"241","volume":"250","year":"1987","journal-title":"Cell & Tissue Research"},{"key":"2026010713033013100_MHAOUTY-ETAL-1995","doi-asserted-by":"crossref","first-page":"11012","DOI":"10.1074\/jbc.270.18.11012","volume":"270","year":"1995","journal-title":"Journal of Biological Chemistry"},{"key":"2026010713033013100_MIONE-AND-GABELLA-1991","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1097\/00001756-199109000-00010","volume":"2","year":"1991","journal-title":"Neuroreport"},{"key":"2026010713033013100_MOUSTAFA-1988","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1159\/000146593","volume":"132","year":"1988","journal-title":"Acta Anatomy (Basel)"},{"key":"2026010713033013100_NORSTROM-AND-BRYMAN-1989","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000293610","volume":"27","year":"1989","journal-title":"Gynecologic and Obstetric Investigation"},{"key":"2026010713033013100_OWMAN-1981","first-page":"252","volume":"83","year":"1981","journal-title":"Ciba Foundation Symposium"},{"key":"2026010713033013100_OWMAN-ETAL-1980","first-page":"313","volume":"25","year":"1980","journal-title":"Advances in Biochemistry & Psychopharmacology"},{"key":"2026010713033013100_PAPKA-ETAL-1985","first-page":"475","volume":"242","year":"1985","journal-title":"Cell & Tissue Research"},{"key":"2026010713033013100_TAMMELA-ETAL-1990","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/BF00300785","volume":"18","year":"1990","journal-title":"Urology Research"},{"key":"2026010713033013100_THORBERT-ETAL-1979","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0002-9378(79)90348-X","volume":"135","year":"1979","journal-title":"American Journal of Obstetrics & Gynecology"},{"key":"2026010713033013100_VAN-ORDEN-ETAL-1980","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1210\/endo-106-5-1650","volume":"106","year":"1980","journal-title":"Endocrinology"},{"key":"2026010713033013100_VAROL-ETAL-2000","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0304-3940(00)01533-0","volume":"294","year":"2000","journal-title":"Neuroscience Letters"},{"key":"2026010713033013100_WIKLAND-ETAL-1984","first-page":"503","volume":"64","year":"1984","journal-title":"Obstetrics & Gynecology"},{"key":"2026010713033013100_ZOUBINA-AND-SMITH-2001","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0306-4522(00)00549-2","volume":"103","year":"2001","journal-title":"Neuroscience"}],"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rep.bioscientifica.com\/view\/journals\/rep\/130\/5\/1300743.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/130\/5\/743\/64607622\/1300743.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/130\/5\/743\/64607622\/1300743.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T18:15:40Z","timestamp":1767809740000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/130\/5\/743\/8252290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,1]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,11,1]]}},"URL":"https:\/\/doi.org\/10.1530\/rep.1.00811","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2005,11,1]]},"published":{"date-parts":[[2005,11,1]]}}}