{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:54:51Z","timestamp":1790639691142,"version":"4.1.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Siberian hamster reproduction is mediated by photoperiod-induced changes in gonadal activity. However, little is known about how photoperiod induces cellular changes in ovarian function. We hypothesized that exposing female hamsters to short (inhibitory) as opposed to long (control) photoperiods would induce an apoptosis-mediated disruption of ovarian function. Ovaries and plasma from hamsters exposed to either long (LD, 16 h light:8 h darkness) or short (SD, 8 h light:16 h darkness) days were collected during diestrus II after 3, 6, 9 and 12 weeks and processed for histology or RIA respectively. Apoptosis was assessed by in situ TUNEL and active caspase-3 protein immunolabeling. No significant differences were observed among LD hamsters for any parameter; therefore, these control data were pooled. SD exposure induced a decline in preantral follicles (P &amp;lt; 0.05), early antral\/antral follicles (P &amp;lt; 0.01) and corpora lutea (P &amp;lt; 0.01) by week 12 as compared with LD. Terminal atretic follicles appeared by SD week 9; by week 12, these had become the predominant ovarian structures. Estradiol concentrations decreased by weeks 9 and 12 SD when compared with both LD and week-3 SD hamsters (P &amp;lt; 0.05); however, no changes were observed for progesterone. TUNEL-positive follicles in SD ovaries increased at week 3 and subsequently declined by week 12 as compared with LD ovaries (P &amp;lt; 0.01). Active capsase-3 protein immunostaining peaked at SD week 3 as compared with all other groups (P &amp;lt; 0.01). TUNEL and capsase-3 immunolabeling were localized to granulosa cells of late-preantral and early-antral\/antral follicles. These data indicate that SD exposure rapidly induces follicular apoptosis in Siberian hamsters, which ultimately disrupts both estradiol secretion and folliculogenesis, resulting in the seasonal loss of ovarian function.<\/jats:p>","DOI":"10.1530\/rep.1.00870","type":"journal-article","created":{"date-parts":[[2006,4,4]],"date-time":"2006-04-04T14:33:09Z","timestamp":1144161189000},"page":"771-782","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":48,"title":["Short photoperiod-induced ovarian regression is mediated by apoptosis in Siberian hamsters (\n                    <i>Phodopus sungorus<\/i>\n                    )"],"prefix":"10.1093","volume":"131","author":[{"given":"C S","family":"Moffatt-Blue","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, California State University Long Beach, Long Beach, CA 90840, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J J","family":"Sury","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, California State University Long Beach, Long Beach, CA 90840, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly A","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, California State University Long Beach, Long Beach, CA 90840, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,4,1]]},"reference":[{"key":"2026010713101943900_ANZICK-ETAL-1997","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1126\/science.277.5328.965","volume":"277","year":"1997","journal-title":"Science"},{"key":"2026010713101943900_BEASLEY-ETAL-1981","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1095\/biolreprod24.5.962","volume":"24","year":"1981","journal-title":"Biology of Reproduction"},{"key":"2026010713101943900_BERGMANN-1987","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-642-71930-1_1","volume":"105","year":"1987","journal-title":"Advances in Anatomy, Embryology, and Cell Biology"},{"key":"2026010713101943900_BRAW-AND-TSAFIRI-1980","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1530\/jrf.0.0590259","volume":"59","year":"1980","journal-title":"Journal of Reproduction and Fertility"},{"key":"2026010713101943900_BRONSON-1989","year":"1989"},{"key":"2026010713101943900_BUCHANAN-AND-YELLON-1991","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1159\/000125857","volume":"54","year":"1991","journal-title":"Neuroendocrinology"},{"key":"2026010713101943900_CARROLL-ETAL-2000","first-page":"3570","volume":"6","year":"2000","journal-title":"Clinical Cancer Research"},{"key":"2026010713101943900_CHUN-ETAL-1994","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1210\/endo.135.5.7525255","volume":"135","year":"1994","journal-title":"Endocrinology"},{"key":"2026010713101943900_CLARKE-AND-SUTHERLAND-1990","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1210\/edrv-11-2-266","volume":"11","year":"1990","journal-title":"Endocrine Reviews"},{"key":"2026010713101943900_CONDON-ETAL-2003","doi-asserted-by":"crossref","first-page":"9518","DOI":"10.1073\/pnas.1633616100","volume":"100","year":"2003","journal-title":"PNAS"},{"key":"2026010713101943900_COUCOUVANIS-ETAL-1993","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1006\/excr.1993.1307","volume":"209","year":"1993","journal-title":"Experimental Cell Research"},{"key":"2026010713101943900_DODGE-AND-BADURA-2002A","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0006-8993(02)02874-3","volume":"946","year":"2002","journal-title":"Brain Research"},{"key":"2026010713101943900_DODGE-ETAL-2002B","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0031-9384(02)00851-X","volume":"77","year":"2002","journal-title":"Physiological Behaviour"},{"key":"2026010713101943900_FENWICK-AND-HURST-2002","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1530\/rep.0.1240659","volume":"124","year":"2002","journal-title":"Reproduction"},{"key":"2026010713101943900_FURUTA-ETAL-1994","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1095\/biolreprod51.6.1315","volume":"51","year":"1994","journal-title":"Biology of Reproduction"},{"key":"2026010713101943900_GLASS-1986","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1095\/biolreprod35.3.733","volume":"35","year":"1986","journal-title":"Biology of Reproduction"},{"key":"2026010713101943900_GUO-ETAL-1998","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1095\/biolreprod58.3.739","volume":"58","year":"1998","journal-title":"Biology of Reproduction"},{"key":"2026010713101943900_HOFFMANN-1979","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0079-6123(08)62946-5","volume":"52","year":"1979","journal-title":"Progress in Brain Research"},{"key":"2026010713101943900_HOFFMANN-AND-ILLNEROVA-1986","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1159\/000124562","volume":"43","year":"1986","journal-title":"Neuroendocrinology"},{"key":"2026010713101943900_HORWITZ-ETAL-1996","first-page":"1167","volume":"10","year":"1996","journal-title":"Molecular Endocrinology"},{"key":"2026010713101943900_HSUEH-ETAL-1996","first-page":"433","volume":"51","year":"1996","journal-title":"Recent Progress in Hormone Research"},{"key":"2026010713101943900_HUGHES-JR-AND-GOROSPE-1991","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1210\/endo-129-5-2415","volume":"129","year":"1991","journal-title":"Endocrinology"},{"key":"2026010713101943900_JOHNSON-2003","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0378-4320(03)00090-3","volume":"78","year":"2003","journal-title":"Animal Reproduction Science"},{"key":"2026010713101943900_KNIGGE-AND-LEATHEM-1956","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/ar.1091240406","volume":"124","year":"1956","journal-title":"Anatomy Records"},{"key":"2026010713101943900_KNOPPER-AND-BOILY-2000","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1086\/317730","volume":"73","year":"2000","journal-title":"Physiological and Biochemical Zoology"},{"key":"2026010713101943900_LUO-ETAL-1997","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/(SICI)1097-0215(19971104)73:3<381::AID-IJC13>3.0.CO;2-G","volume":"73","year":"1997","journal-title":"International Journal of Cancer"},{"key":"2026010713101943900_MATIKAINEN-ETAL-2001","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1210\/endo.142.6.8078","volume":"142","year":"2001","journal-title":"Endocrinology"},{"key":"2026010713101943900_MORITA-AND-TILLY-1999","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/dbio.1999.9344","volume":"213","year":"1999","journal-title":"Developmental Biology"},{"key":"2026010713101943900_OHNO-AND-SMITH-1964","first-page":"324","volume":"13","year":"1964","journal-title":"Cytogenetics"},{"key":"2026010713101943900_PALUMBO-AND-YEH-1994","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1095\/biolreprod51.5.888","volume":"51","year":"1994","journal-title":"Biology of Reproduction"},{"key":"2026010713101943900_PRENDERGAST-AND-NELSON-2001","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1098\/rspb.2001.1784","volume":"268","year":"2001","journal-title":"Proceedings in Biological Science"},{"key":"2026010713101943900_PYTER-ETAL-2005","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1530\/rep.1.00448","volume":"129","year":"2005","journal-title":"Reproduction"},{"key":"2026010713101943900_REBURN-AND-WYNNE-EDWARDS-1996","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1095\/biolreprod54.4.819","volume":"54","year":"1996","journal-title":"Biology of Reproduction"},{"key":"2026010713101943900_ROUGHTON-ETAL-1999","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1095\/biolreprod60.4.797","volume":"60","year":"1999","journal-title":"Biology of Reproduction"},{"key":"2026010713101943900_SCHLATT-ETAL-1993","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1095\/biolreprod49.2.243","volume":"49","year":"1993","journal-title":"Biology of Reproduction"},{"key":"2026010713101943900_SCHMIDT-AND-KELLEY-2001","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/1097-010X(20010101\/31)289:1<66::AID-JEZ7>3.0.CO;2-Q","volume":"289","year":"2001","journal-title":"Journal of Experimental Zoology"},{"key":"2026010713101943900_SNELL-1941","year":"1941"},{"key":"2026010713101943900_TERRANOVA-1981","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1210\/endo-108-5-1885","volume":"108","year":"1981","journal-title":"Endocrinology"},{"key":"2026010713101943900_TILLY-ETAL-1991","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1210\/endo-129-5-2799","volume":"129","year":"1991","journal-title":"Endocrinology"},{"key":"2026010713101943900_UILENBROEK-ETAL-1980","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1095\/biolreprod23.1.219","volume":"23","year":"1980","journal-title":"Biology of Reproduction"},{"key":"2026010713101943900_VAN-DEN-HURK-ETAL-2002","first-page":"701","volume":"147","year":"2002","journal-title":"European Journal of Endocrinology"},{"key":"2026010713101943900_VAUGHAN-ETAL-1994","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3181\/00379727-205-43714","volume":"205","year":"1994","journal-title":"Proceedings of the Society of Experimental Biology and Medicine"},{"key":"2026010713101943900_VAUX-AND-STRASSER-1996","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1073\/pnas.93.6.2239","volume":"93","year":"1996","journal-title":"PNAS"},{"key":"2026010713101943900_WEST-ETAL-1978","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1210\/endo-103-5-1732","volume":"103","year":"1978","journal-title":"Endocrinology"},{"key":"2026010713101943900_WYNNE-EDWARDS-ETAL-1987","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1210\/endo-120-4-1308","volume":"120","year":"1987","journal-title":"Endocrinology"},{"key":"2026010713101943900_YELLON-AND-GOLDMAN-1987","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1530\/jrf.0.0800167","volume":"80","year":"1987","journal-title":"Journal of Reproduction and Fertility"},{"key":"2026010713101943900_YOUNG-AND-NELSON-2000","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1152\/ajpregu.2000.279.3.R1132","volume":"279","year":"2000","journal-title":"American Journal of Physiology\u2013Regulatory, Integrative and Comparative Physiology"},{"key":"2026010713101943900_YOUNG-AND-NELSON-2001","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1530\/rep.0.1220677","volume":"122","year":"2001","journal-title":"Reproduction"},{"key":"2026010713101943900_YOUNG-ETAL-1999","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1210\/endo.140.7.6870","volume":"140","year":"1999","journal-title":"Endocrinology"},{"key":"2026010713101943900_YOUNG-ETAL-2001","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1177\/074873001129002150","volume":"16","year":"2001","journal-title":"Journal of Biological Rhythms"},{"key":"2026010713101943900_ZELEZNICK-ETAL-1989","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1210\/endo-125-4-2218","volume":"125","year":"1989","journal-title":"Endocrinology"}],"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rep.bioscientifica.com\/view\/journals\/rep\/131\/4\/1310771.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rep.bioscientifica.com\/downloadpdf\/journals\/rep\/131\/4\/1310771.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/131\/4\/771\/64609046\/1310771.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/131\/4\/771\/64609046\/1310771.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T18:20:03Z","timestamp":1767810003000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/131\/4\/771\/8252405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,1]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4,1]]}},"URL":"https:\/\/doi.org\/10.1530\/rep.1.00870","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2006,4,1]]},"published":{"date-parts":[[2006,4,1]]}}}