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We investigated anti-\u03b22-GPI and anti-annexin V IgM and IgG antibodies as potential risk factors for RSA in 200 women with more than three consecutive idiopathic RSA, and 200 age-matched, healthy, parous women. Pearson\u2019s chi squared test analysis showed that while anti-\u03b22-GPI IgG (P = 0.416) and IgM (P = 0.72) were comparable between patients and controls, elevated anti-annexin V IgG (P = 0.006), but not IgM (P = 0.084), was more pronounced in patients. Higher frequencies of elevated IgG-only (P = 0.005), but not IgM-only (P = 1.000; OR = 6.66), anti-annexin V antibodies were noted among patients. Multinomial regression analysis showed that body-mass index (overweight and obesity; P = 0.008), education status (P &amp;lt; 0.001) and anti-\u03b22-GPI IgM (P = 0.033), but not IgG (P = 0.723), were associated with early abortion, while anti-\u03b22-GPI IgG (P = 0.030) and anti-annexin V IgG (P = 0.004) were associated with late RSA. For combined early-late RSA, the only variable selected was education status (P &amp;lt; 0.001), and neither anti-annexin V nor anti-\u03b22-GPI IgM and IgG was associated with early-late RSA. Accordingly, anti-annexin V and anti-\u03b22-GPI should be regarded as independent risk markers of RSA.<\/jats:p>","DOI":"10.1530\/rep.1.01060","type":"journal-article","created":{"date-parts":[[2006,4,4]],"date-time":"2006-04-04T14:33:09Z","timestamp":1144161189000},"page":"817-822","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":27,"title":["A case-control study on the association of idiopathic recurrent pregnancy loss with autoantibodies against \u03b22-glycoprotein I and annexin V"],"prefix":"10.1093","volume":"131","author":[{"given":"Walid","family":"Zammiti","sequence":"first","affiliation":[{"name":"Laboratory of Hematology, Faculty of Pharmacy, University of Monastir, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabil","family":"Mtiraoui","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology, Faculty of Pharmacy, University of Monastir, 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