{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T19:21:17Z","timestamp":1783452077985,"version":"3.55.0"},"reference-count":32,"publisher":"Bioscientifica","issue":"1","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":183,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 815 TP01, TP08, SFB 834"],"award-info":[{"award-number":["SFB 815 TP01, TP08, SFB 834"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:p>Atherosclerosis is a progressive inflammatory disease, of which initiation and progression are potentially mediated by myeloid cells. An imbalance of oxygen supply and, therefore, hypoxic situations in the arterial wall have been hypothesized to be a major driver of development and progression of atherosclerosis. Herein, we analyze the significance of hypoxia-inducible factor (HIF) in myeloid cells in atherosclerosis. Myeloid-specific Hif1\u03b1 and Hif2\u03b1 knockout mice were crossed into the ApoE\u2212\/\u2212 background, and angiotensin II (AngII) infusion was performed to induce accelerated plaque formation. Myeloid Hif1\u03b1, but not Hif2\u03b1, limited the increase in heart weight after 7 days of AngII infusion, indicating a transient protective effect restricted to early phases of AngII-induced remodeling. With prolonged treatment (4 weeks), these differences were lost, suggesting a protective role for myeloid HIF-1\u03b1 only in early hypertension-induced cardiac hypertrophy. Macrophages of aged mice (12 months old) showed decreased expression of Hif1\u03b1 and Hif2\u03b1, which did not yield overt differences in classical\/alternative polarization markers. Nevertheless, aged ApoE\u2212\/\u2212 mice with macrophage-specific Hif1\u03b1 knockout had a higher body weight and developed more aortic plaques compared to wild-type littermates. These observations suggest that activation of Hif1\u03b1 in macrophages may be protective for plaque formation under chronic hyperlipidemic conditions. Supporting this, a reanalysis of single-cell RNA-sequencing data from human atherosclerotic and normal vessel wall specimens shows that HIF target gene expression is elevated in anti-inflammatory macrophage subsets along pseudotime trajectories. This association suggests that macrophage HIF1\u03b1 activity may contribute to reparative or stabilizing responses during plaque progression.<\/jats:p>","DOI":"10.1530\/vb-25-0011","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T17:40:09Z","timestamp":1768239609000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-12","source":"Crossref","is-referenced-by-count":0,"title":["Myeloid HIF1\u03b1 has only a minor impact on atherosclerosis development"],"prefix":"10.1530","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0822-2180","authenticated-orcid":true,"given":"Nathalie","family":"Dehne","sequence":"first","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3099-526X","authenticated-orcid":true,"given":"Katrin","family":"Schr\u00f6der","sequence":"additional","affiliation":[{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"2026070714164526800_bib1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis \u2013 an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N Engl J Med"},{"key":"2026070714164526800_bib2","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1161\/CIRCRESAHA.114.301174","article-title":"Mechanisms that regulate 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