{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T16:01:20Z","timestamp":1785254480308,"version":"3.55.0"},"reference-count":59,"publisher":"Bioscientifica","issue":"1","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":195,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The human placenta is the nexus of maternal\u2013fetal exchange, with its function reflected in histological features such as syncytial knots. These nuclear aggregations within the syncytiotrophoblast, historically termed Tenney\u2013Parker changes when excessive, serve as critical markers of both placental maturation and maladaptation. This narrative review synthesizes the current understanding of their structural, ultrastructural, and molecular features, emphasizing the biological significance of the syncytial knot index as a quantitative marker of placental function. The syncytial knot index rises progressively with gestation but increases prematurely in conditions such as preeclampsia, fetal growth restriction, maternal vascular malperfusion, and chronic hypoxia, reflecting accelerated syncytiotrophoblast aging and oxidative injury. This review also highlights the mechanistic pathways \u2013 apoptosis, senescence, hypoxia-driven signaling, and disturbed trophoblast turnover \u2013 that determine knot formation. Emerging evidence on syncytiotrophoblast-derived microparticles illustrates their potential role in mediating maternal endothelial dysfunction and systemic manifestations of placental disease. Despite its diagnostic value, the syncytial knot index remains underutilized due to methodological variability; however, digital pathology, stereology, and 3D imaging now offer promising avenues for standardized assessment.<\/jats:p>","DOI":"10.1530\/vb-26-0004","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T17:38:43Z","timestamp":1784137123000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-12","source":"Crossref","is-referenced-by-count":0,"title":["Placental syncytial knots in the spectrum of maternal vascular malperfusion: mechanisms and clinical implications"],"prefix":"10.1530","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9956-2246","authenticated-orcid":true,"given":"Seetu","family":"Palo","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bibinagar 1 , , ,","place":["Hyderabad, Telangana, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0708-1037","authenticated-orcid":true,"given":"Mishu","family":"Mangla","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology, All India Institute of Medical Sciences, Bibinagar 2 , , ,","place":["Hyderabad, Telangana, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2002-5198","authenticated-orcid":true,"given":"Rohini","family":"Motwani","sequence":"additional","affiliation":[{"name":"Department of Anatomy, All India Institute of Medical Sciences, Bibinagar 3 , , ,","place":["Hyderabad, Telangana, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"2026072811311707800_bib1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2350\/09-08-0692-OA.1","article-title":"Syncytial knots as a reflection of 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