{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T23:45:02Z","timestamp":1767915902324,"version":"3.49.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1979,7,1]],"date-time":"1979-07-01T00:00:00Z","timestamp":299635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["reproduction-online.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1979,7,1]]},"abstract":"<jats:p>Summary. Intrauterine, but not systemic, administration of actinomycin D on Day 10 increased oestrous cycle length in guinea-pigs. Peripheral plasma progesterone levels remained elevated during these lengthened cycles presumably because luteal life-span had been extended. Prostaglandin (PG) F-2\u03b1 production in vitro, on Day 15, by the uterus of guinea-pigs which had received intrauterine actinomycin D was much lower than control values. This decrease in PG production was not due to lack of precursor, increased metabolism, re-direction of synthesis towards PGE-2, or a direct inhibition by actinomycin D of the conversion of arachidonic acid to PGs. The effects of actinomycin D treatment were not reversed by oestradiol.<\/jats:p>\n                  <jats:p>It is proposed that actinomycin D prevents the increase in uterine PG synthetase levels that normally takes place after Day 11, thereby reducing uterine PGF-2\u03b1 synthesis and output in vivo, and resulting in luteal maintenance and longer oestrous cycles.<\/jats:p>","DOI":"10.1530\/jrf.0.0560559","type":"journal-article","created":{"date-parts":[[2004,3,20]],"date-time":"2004-03-20T03:12:46Z","timestamp":1079752366000},"page":"559-565","update-policy":"https:\/\/doi.org\/10.1530\/rep\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Effect of actinomycin D on uterine prostaglandin production and oestrous cycle length in guinea-pigs"],"prefix":"10.1093","volume":"56","author":[{"given":"N. L.","family":"Poyser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1979,7,1]]},"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/56\/2\/559\/64933357\/jrf_56_2_019.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/56\/2\/559\/64933357\/jrf_56_2_019.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:17:16Z","timestamp":1767896236000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/56\/2\/559\/8290164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,7,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1979,7,1]]}},"URL":"https:\/\/doi.org\/10.1530\/jrf.0.0560559","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1979,7,1]]},"published":{"date-parts":[[1979,7,1]]}}}