{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:27:43Z","timestamp":1775082463683,"version":"3.50.1"},"reference-count":0,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>Previous studies suggested that subclinical hypothyroidism has a detrimental effect on cardiovascular risk factors, and that its effective treatment may have a beneficial impact on overall health. The main purpose of this review and meta-analysis was to assess whether subclinical hypothyroidism treatment is of clinical relevance, based on cardiovascular risk parameters correction. A systemic research of the literature using MEDLINE tool was performed to identify the relevant studies. Only placebo-controlled randomized control trials were included. A quantitative analysis was also performed. This systematic review and meta-analysis of randomized placebo-controlled trials assess the different impact of levothyroxine vs placebo treatment. A significant decrease in serum thyroid-stimulating hormone and total and low-density lipoprotein cholesterol was obtained with levothyroxine therapy (66, 9 and 14%, respectively) and, although modest, this could be significant in terms of reduction of the incidence of coronary artery disease. Other significant results of lipid parameters were not obtained. This systematic review provides a strong evidence-based data in favour of specific changes and beneficial effects of levothyroxine treatment.<\/jats:p>","DOI":"10.1530\/ec-17-0028","type":"journal-article","created":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T01:20:39Z","timestamp":1488417639000},"page":"188-199","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":46,"title":["Subclinical hypothyroidism: to treat or not to treat, that is the question! A systematic review with meta-analysis on lipid profile"],"prefix":"10.1530","volume":"6","author":[{"given":"Isabel M","family":"Abreu","sequence":"first","affiliation":[{"name":"1Faculty of MedicineUniversity of Porto, Alameda Professor Hern\u00e2ni Monteiro, Porto, Portugal"}]},{"given":"Eva","family":"Lau","sequence":"additional","affiliation":[{"name":"1Faculty of MedicineUniversity of Porto, Alameda Professor Hern\u00e2ni Monteiro, Porto, Portugal"},{"name":"2Department of EndocrinologyDiabetes and Metabolism, Centro Hospitalar S. Jo\u00e3o, Alameda Professor Hern\u00e2ni Monteiro, Porto, Portugal"},{"name":"3Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fadeUniversidade do Porto, Porto, Portugal"}]},{"given":"Bernardo","family":"de Sousa Pinto","sequence":"additional","affiliation":[{"name":"1Faculty of MedicineUniversity of Porto, Alameda Professor Hern\u00e2ni Monteiro, Porto, Portugal"}]},{"given":"Davide","family":"Carvalho","sequence":"additional","affiliation":[{"name":"1Faculty of MedicineUniversity of Porto, Alameda Professor Hern\u00e2ni Monteiro, Porto, Portugal"},{"name":"2Department of EndocrinologyDiabetes and Metabolism, Centro Hospitalar S. Jo\u00e3o, Alameda Professor Hern\u00e2ni Monteiro, Porto, Portugal"},{"name":"3Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fadeUniversidade do Porto, Porto, Portugal"}]}],"member":"416","container-title":["Endocrine Connections"],"original-title":[],"link":[{"URL":"https:\/\/ec.bioscientifica.com\/view\/journals\/ec\/6\/3\/188.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ec.bioscientifica.com\/downloadpdf\/journals\/ec\/6\/3\/188.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T17:31:34Z","timestamp":1608658294000},"score":1,"resource":{"primary":{"URL":"https:\/\/ec.bioscientifica.com\/view\/journals\/ec\/6\/3\/188.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/ec-17-0028","relation":{},"ISSN":["2049-3614"],"issn-type":[{"value":"2049-3614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4]]}}}