{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T11:01:28Z","timestamp":1776250888069,"version":"3.50.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The European Registry on Cushing's syndrome (ERCUSYN) is designed to collect prospective and follow-up data at EU level on Cushing's syndrome (CS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and methods<\/jats:title><jats:p>Baseline data on 481 CS patients (390 females, 91 males; mean age (\u00b1<jats:sc>s.d.<\/jats:sc>): 44\u00b114 years) collected from 36 centres in 23 countries, including new patients from 2008 and retrospective cases since 2000. Patients were divided into four major aetiologic groups: pituitary-dependent CS (PIT-CS) (66%), adrenal-dependent CS (ADR-CS) (27%), CS from an ectopic source (ECT-CS) (5%) and CS from other aetiologies (2%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Proportion of men in the ECT-CS group was higher than in the other groups (<jats:italic>P<\/jats:italic>&lt;0.05). The ADR-CS group was older than the PIT-CS (<jats:italic>P<\/jats:italic>&lt;0.05). Prevalence of hirsutism (92%) and diabetes (74%) in ECT-CS was higher than in the other groups (<jats:italic>P<\/jats:italic>&lt;0.05 and <jats:italic>P<\/jats:italic>&lt;0.01 respectively). PIT-CS had more skin alterations, menstrual irregularities and hirsutism than ADR-CS (<jats:italic>P<\/jats:italic>&lt;0.01). Reduced libido was more prevalent in men than women (<jats:italic>P<\/jats:italic>&lt;0.01). Prevalence of spine osteoporosis was higher in men than women (<jats:italic>P<\/jats:italic>&lt;0.05), and males had more vertebral and rib fractures than females (52 vs 18% for vertebrae; <jats:italic>P<\/jats:italic>&lt;0.001 and 34 vs 23% for ribs; <jats:italic>P<\/jats:italic>&lt;0.05). ECT-CS consulted a diabetologist more frequently than ADR-CS (<jats:italic>P<\/jats:italic>&lt;0.05), while a gynaecologist was consulted more often by women with PIT-CS or ADR-CS than with ECT-CS (<jats:italic>P<\/jats:italic>&lt;0.05). Overall, weight gain was more common in women than men (<jats:italic>P<\/jats:italic>&lt;0.01). CushingQoL and EuroQoL visual analogue scale scores did not differ between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The ERCUSYN project demonstrates a heterogeneous clinical presentation of CS at a European level, depending on gender and aetiology.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-11-0272","type":"journal-article","created":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T00:27:02Z","timestamp":1309393622000},"page":"383-392","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":327,"title":["The European Registry on Cushing's syndrome: 2-year experience. 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