{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:25:00Z","timestamp":1761017100370},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>Context<\/jats:title><jats:p>Elevated heart rate has been associated with insulin resistance and incident type 2 diabetes but its relationship with \u03b2-cell function is not known. Our aim was to investigate whether baseline heart rate is associated with \u03b2-cell function and hyperglycaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used the prospective RISC cohort with 1005 non-diabetic individuals who had an oral glucose tolerance test (OGTT) at baseline and after 3 years. Impaired glucose regulation was defined as a fasting plasma glucose \u22656.1\u200ammol\/l or a 2-h plasma glucose \u22657.8\u200ammol\/l. Insulin sensitivity was assessed by the OGIS index and insulin secretion and \u03b2-cell glucose sensitivity at both baseline and 3 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline heart rate was positively related to both fasting (<jats:italic>P<\/jats:italic>&lt;0.0001) and 2\u200ah glucose levels (<jats:italic>P<\/jats:italic>=0.02) at year 3 and predicted the presence of impaired glucose regulation at year 3 in a logistic regression model adjusting for insulin sensitivity at inclusion (OR\/10\u200abeats per min: 1.31; 95% CI (1.07\u20131.61);<jats:italic>P<\/jats:italic>=0.01). Baseline heart rate was associated with lower insulin sensitivity (<jats:italic>\u03b2<\/jats:italic>=\u22120.11;<jats:italic>P<\/jats:italic>&lt;.0001), a decrease in both \u03b2-cell glucose sensitivity (<jats:italic>\u03b2<\/jats:italic>=\u22120.11;<jats:italic>P<\/jats:italic>=0.003) and basal insulin secretion rate (<jats:italic>\u03b2<\/jats:italic>=\u22120.11;<jats:italic>P<\/jats:italic>=0.002) at 3 years in an adjusted multivariable regression model. Baseline heart rate predicted the 3-year decrease in \u03b2-cell glucose sensitivity (<jats:italic>\u03b2<\/jats:italic>=\u22120.10;<jats:italic>P<\/jats:italic>=0.007) and basal insulin secretion (<jats:italic>\u03b2<\/jats:italic>=\u22120.12;<jats:italic>P<\/jats:italic>=0.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Heart rate predicts \u03b2-cell function and impaired glucose regulation at 3 years in non-diabetic individuals, independently of the level of insulin sensitivity. These findings suggest a possible effect of the sympathetic nervous system on \u03b2-cell dysfunction, which deserves further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-15-0115","type":"journal-article","created":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T15:23:35Z","timestamp":1433258615000},"page":"409-415","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":7,"title":["Elevated heart rate predicts \u03b2 cell function in non-diabetic individuals: the RISC cohort"],"prefix":"10.1093","volume":"173","author":[{"given":"Fabrice","family":"Bonnet","sequence":"first","affiliation":[]},{"given":"Jean-Philippe","family":"Empana","sequence":"additional","affiliation":[]},{"given":"Andrea","family":"Natali","sequence":"additional","affiliation":[]},{"given":"Lucilla","family":"Monti","sequence":"additional","affiliation":[]},{"given":"Alain","family":"Golay","sequence":"additional","affiliation":[]},{"given":"Katarina","family":"Lalic","sequence":"additional","affiliation":[]},{"given":"Jacqueline","family":"Dekker","sequence":"additional","affiliation":[]},{"given":"Andrea","family":"Mari","sequence":"additional","affiliation":[]},{"given":"Beverley","family":"Balkau","sequence":"additional","affiliation":[]},{"given":"_","family":"_","sequence":"additional","affiliation":[]}],"member":"286","reference":[{"key":"2015080619101895000_173.3.409.1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000066324.74807.95"},{"key":"2015080619101895000_173.3.409.2","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0874"},{"key":"2015080619101895000_173.3.409.3","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.331"},{"key":"2015080619101895000_173.3.409.4","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq068"},{"key":"2015080619101895000_173.3.409.5","unstructured":"Bemelmans RH Wassink AM van der Graaf Y Nathoe HM Vernooij JW Spiering W Visseren FL . 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