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This review addresses only genetic alterations detected by molecular methods in surgically resected specimens, thus ruling out immunohistochemistry and (F)ISH, despite their crucial relevance as topographically oriented methods. For the sake of the discussion, well-differentiated carcinomas were divided into two main morphologic types: papillary carcinoma (classic and most variants) displaying BRAFV600E mutations and RET\/papillary thyroid carcinoma rearrangements and the group of follicular patterned carcinomas that encompasses follicular carcinoma and the encapsulated form of follicular variant of papillary carcinoma, displaying RAS mutations and PAX8\/PPAR\u03b3 rearrangement. TERT promoter mutations have been recently described (and associated with distant metastases and reduced survival) in papillary and follicular carcinomas, as well as in poorly differentiated and undifferentiated carcinoma. TP53 mutations, previously thought to be restricted to less differentiated carcinomas, were also detected in papillary and follicular carcinoma and found to carry a guarded prognosis. Besides their putative importance for targeted therapies, the prognostic meaning of such mutations is discussed<jats:italic>per se<\/jats:italic>and in the setting of concurrent BRAF mutation.<\/jats:p>","DOI":"10.1530\/eje-15-0605","type":"journal-article","created":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T03:05:19Z","timestamp":1446087919000},"page":"R117-R126","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":70,"title":["ENDOCRINE TUMOURS: Genetic predictors of thyroid cancer outcome"],"prefix":"10.1093","volume":"174","author":[{"given":"Catarina","family":"Tavares","sequence":"first","affiliation":[]},{"given":"Miguel","family":"Melo","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 Manuel","family":"Cameselle-Teijeiro","sequence":"additional","affiliation":[]},{"given":"Paula","family":"Soares","sequence":"additional","affiliation":[]},{"given":"Manuel","family":"Sobrinho-Sim\u00f5es","sequence":"additional","affiliation":[]}],"member":"286","reference":[{"key":"2016022218335235000_174.4.R117.1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-012-1234-y"},{"key":"2016022218335235000_174.4.R117.2","doi-asserted-by":"crossref","unstructured":"Rosai JD, Frable WJ & Tallini G. 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