{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T04:40:17Z","timestamp":1778215217092,"version":"3.51.4"},"reference-count":10,"publisher":"Bioscientifica","issue":"1","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["eo.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:sec>\n<jats:title>Summary<\/jats:title>\n<jats:p>Primary hyperparathyroidism (PHPT) is the unregulated overproduction of parathyroid hormone (PTH), resulting in abnormal calcium homeostasis. PHPT is most commonly caused by a single adenoma of the parathyroid gland, which can have an intrathyroid location in rare cases. The measurement of intact PTH in the washout fluid obtained by ultrasound (US)-guided fineneedle aspiration (FNA) can be useful in clarifying the aetiology of these lesions. This study presented a 48-year-old man with a background history of symptomatic renal stone disease who was diagnosed with PHPT and referred to our Endocrinology department. A neck US revealed a thyroid nodule with a size of 21 mm in the right lobe. The patient underwent US-guided FNA of the lesion. The measurement of PTH in the washout fluid was significantly elevated. Following the procedure, he reported neck pain and noticed distal paraesthesias in the upper limbs. Blood test results showed significant hypocalcaemia and supplementation with calcium and calcitriol was started. The patient was closely monitored. Recurrence of hypercalcaemia was later observed, and the patient was submitted to surgery. We present a case of FNAinduced transitory remission of PHPT in a patient with an intrathyroid parathyroid adenoma. We conjecture that intra-nodular haemorrhage might have occurred, which temporarily affected the viability of the autonomous parathyroid tissue. A few similar cases of spontaneous or induced remission of PHPT after FNA have been previously described in the literature. This remission can be transitory or permanent, depending on the degree of cellular damage thus follow-up of these patients is recommended.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eo-22-0060","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T11:48:18Z","timestamp":1662464898000},"page":"K10-K14","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-15","source":"Crossref","is-referenced-by-count":3,"title":["Transient remission of hyperparathyroidism after fine-needle aspiration biopsy"],"prefix":"10.1530","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3706-9277","authenticated-orcid":true,"given":"Ana Rita","family":"Elvas","sequence":"first","affiliation":[{"name":"Endocrinology Department, Portuguese Institute of Oncology of Coimbra FG, Coimbra, Portugal"}]},{"given":"Andreia","family":"Martins Fernandes","sequence":"additional","affiliation":[{"name":"Endocrinology Department, Portuguese Institute of Oncology of Coimbra FG, Coimbra, Portugal"}]},{"given":"Sara","family":"Reis","sequence":"additional","affiliation":[{"name":"Pathology Department, Portuguese Institute of Oncology of Coimbra FG, Coimbra, Portugal"}]},{"given":"Joana","family":"Couto","sequence":"additional","affiliation":[{"name":"Endocrinology Department, Portuguese Institute of Oncology of Coimbra FG, Coimbra, Portugal"}]},{"given":"Raquel G","family":"Martins","sequence":"additional","affiliation":[{"name":"Endocrinology Department, Portuguese Institute of Oncology of Coimbra FG, Coimbra, Portugal"}]},{"given":"Jacinta","family":"Santos","sequence":"additional","affiliation":[{"name":"Endocrinology Department, Portuguese Institute of Oncology of Coimbra FG, Coimbra, Portugal"}]},{"given":"Teresa","family":"Martins","sequence":"additional","affiliation":[{"name":"Endocrinology Department, Portuguese Institute of Oncology of Coimbra FG, Coimbra, Portugal"}]},{"given":"Bernardo","family":"Marques","sequence":"additional","affiliation":[{"name":"Endocrinology Department, Portuguese Institute of Oncology of Coimbra FG, Coimbra, Portugal"},{"name":"Endocrinology Department, Egas Moniz Hospital, West Lisbon Hospital Center E.P.E., Lisboa, Portugal"}]},{"given":"Joana","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Endocrinology Department, Baixo Vouga Hospital Center E.P.E., Aveiro, Portugal"}]},{"given":"Fernando J C","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Endocrinology Department, Portuguese Institute of Oncology of Coimbra FG, Coimbra, Portugal"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Endocrine Practice","doi-asserted-by":"publisher","first-page":"441","DOI":"10.4158\/EP11148.OR","article-title":"Risks and benefits of parathyroid fine-needle aspiration with parathyroid hormone washout","volume":"18","author":"Bancos","year":"2012","unstructured":"Bancos IGrant CSNadeem SStan MNReading CCSebo TJAlgeciras-Schimnich ASingh RJDean DS2012Risks and benefits of parathyroid fine-needle aspiration with parathyroid hormone washout. Endocrine Practice18441\u2013449. (https:\/\/doi.org\/10.4158\/EP11148.OR)10.4158\/EP11148.OR"},{"key":"bib2","series-title":"Journal of Clinical Endocrinology and Metabolism","doi-asserted-by":"publisher","first-page":"3561","DOI":"10.1210\/jc.2014-1413","article-title":"Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the Fourth International Workshop","volume":"99","author":"Bilezikian","year":"2014","unstructured":"Bilezikian JPBrandi MLEastell RSilverberg SJUdelsman RMarcocci CPotts JT2014Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the Fourth International Workshop. Journal of Clinical Endocrinology and Metabolism993561\u20133569. (https:\/\/doi.org\/10.1210\/jc.2014-1413)10.1210\/jc.2014-1413"},{"key":"bib3","series-title":"Journal of Clinical Medicine","article-title":"Primary hyperparathyroidism: a narrative review of diagnosis and medical management","volume":"10","author":"Dandurand","year":"2021","unstructured":"Dandurand KAli DSKhan AA2021Primary hyperparathyroidism: a narrative review of diagnosis and medical management. Journal of Clinical Medicine10 1604. (https:\/\/doi.org\/10.3390\/jcm10081604)"},{"key":"bib4","series-title":"AACE Clinical Case Reports","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.aace.2020.11.021","article-title":"Remission of primary hyperparathyroidism following fine-needle aspiration biopsy: a case report and review of the literature","volume":"7","author":"Falcetta","year":"2021","unstructured":"Falcetta PCetani FTonacchera M2021Remission of primary hyperparathyroidism following fine-needle aspiration biopsy: a case report and review of the literature. AACE Clinical Case Reports775\u201379. (https:\/\/doi.org\/10.1016\/j.aace.2020.11.021)10.1016\/j.aace.2020.11.021"},{"key":"bib5","series-title":"Gland Surgery","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.21037\/gs-21-6","article-title":"Unexpected remission of hyperparathyroidism caused by hemorrhage due to the use of fine-needle aspiration biopsy: two cases report","volume":"10","author":"Ho","year":"2021","unstructured":"Ho JKim DLee JEChoi SChoi HChoi SKim JKang SWLee JJeong JJ2021Unexpected remission of hyperparathyroidism caused by hemorrhage due to the use of fine-needle aspiration biopsy: two cases report. Gland Surgery102047\u20132053. 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