{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T03:01:32Z","timestamp":1775617292935,"version":"3.50.1"},"reference-count":49,"publisher":"Bioscientifica","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["eor.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:sec>\n<jats:title>Study design<\/jats:title>\n<jats:list list-type=\"bullet\">\n<jats:list-item>\n<jats:p>Systematic review; meta-analysis.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Purpose<\/jats:title>\n<jats:list list-type=\"bullet\">\n<jats:list-item>\n<jats:p>Lumbar degenerative disease is frequent and has a tremendous impact on patients\u2019 disability and quality-of-life. Open and minimally invasive procedures have been used to achieve adequate decompression and fusion. Endoscopic lumbar interbody fusion (Endo-LIF) is emerging as an alternative, trying to reduce morbidity, while achieving comparable to superior clinical outcomes. The aim of this work is to perform a systematic review and meta-analysis to investigate how Endo-LIF compares to open or minimally invasive procedures.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:list list-type=\"bullet\">\n<jats:list-item>\n<jats:p>Electronic databases (MEDLINE, Scopus, Web of Science, Cochrane) were systematically reviewed using the query: \u2018(percutaneous OR endoscop*) AND (open OR minimal* invasive) AND lumbar AND fusion\u2019. PRISMA guidelines were followed.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:list list-type=\"bullet\">\n<jats:list-item>\n<jats:p>Twenty-seven articles were included (25 cohort study, 1 quasi-experimental study, and 1 randomized control trial; for meta-analytical results, only observational studies were considered). Endo-LIF conditioned longer operative time, with significantly lower blood loss, bedtime, and hospital length of stay. Early post-operative back pain favored endoscopic techniques. Endo-LIF and non-Endo-LIF minimally invasive surgery displayed comparable results for most back and leg pain or disability outcomes, despite Endo-LIF having been associated with higher disability at late follow-up (versus Open-LIF). No differences were found regarding fusion rates, cage subsidence, or adverse events. Definitive conclusions regarding fusion rate cannot be drawn due to low number of studies and unstandardized fusion definition.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:list list-type=\"bullet\">\n<jats:list-item>\n<jats:p>Endo-LIF is an effective and safe alternative to conventional lumbar interbody fusion procedures. Evidence shortcomings may be addressed, and future randomized control trials may be performed to compare techniques and to validate results.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list>\n<\/jats:sec>","DOI":"10.1530\/eor-23-0167","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T12:16:32Z","timestamp":1717416992000},"page":"536-555","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-16","source":"Crossref","is-referenced-by-count":7,"title":["Is endoscopic technique an effective and safe alternative for lumbar interbody fusion? A systematic review and meta-analysis"],"prefix":"10.1530","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1018-0810","authenticated-orcid":true,"given":"Miguel","family":"Relvas-Silva","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Traumatology, S\u00e3o Jo\u00e3o Universitary Hospital Centre, Porto, Portugal"},{"name":"NeuroGen Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Dr. Pl\u00e1cido da Costa, Porto, Portugal"}]},{"given":"Bernardo Sousa","family":"Pinto","sequence":"additional","affiliation":[{"name":"MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"CINTESIS@RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Ant\u00f3nio","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, S\u00e3o Jo\u00e3o Universitary Hospital Centre, Porto, Portugal"}]},{"given":"Miguel","family":"Loureiro","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, S\u00e3o Jo\u00e3o Universitary Hospital Centre, Porto, Portugal"},{"name":"Hospital das For\u00e7as Armadas, Porto, Portugal"}]},{"given":"Andr\u00e9 Rodrigues","family":"Pinho","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, S\u00e3o Jo\u00e3o Universitary Hospital Centre, Porto, Portugal"},{"name":"Unit of Anatomy, Department of Biomedicine, Faculty of Medicine, University of Porto, Alameda Professor Hern\u00e2ni Monteiro, Porto, Portugal"}]},{"given":"Pedro","family":"Pereira","sequence":"additional","affiliation":[{"name":"NeuroGen Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Dr. Pl\u00e1cido da Costa, Porto, Portugal"},{"name":"CINTESIS@RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Unit of Anatomy, Department of Biomedicine, Faculty of Medicine, University of Porto, Alameda Professor Hern\u00e2ni Monteiro, Porto, Portugal"}]}],"member":"416","reference":[{"issue":"Supplement","key":"bib1","series-title":"Neurosurgery","first-page":"S1","article-title":"The aging of the global population: the changing epidemiology of disease and spinal disorders","volume":"77","author":"Fehlings","year":"2015","unstructured":"Fehlings MGTetreault LNater AChoma THarrop JMroz TSntaguida C & Smith JS. 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