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The effects of \u03b1-cyano-4-hydroxycinnamate, quercetin and lonidamine on cell viability, metabolism, proliferation, apoptosis, migration and invasion were assessed in a panel of different breast cancer cell lines. MCT1, MCT4 and CD147 were differently expressed among the breast cancer cell lines and, as expected, different sensitivities were observed for the three inhibitors. Interestingly, in the most sensitive cell lines, lactate transport inhibition induced a decrease in cell proliferation, migration and invasion, as well as an increase in cell death. Results were validated by silencing MCT1 expression using siRNA. The results obtained here support targeting of lactate transport as a strategy to treat breast cancer, with a special emphasis on the basal-like subtype, which so far does not have a specific molecular therapy.<\/jats:p>","DOI":"10.1530\/erc-13-0132","type":"journal-article","created":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T03:47:38Z","timestamp":1383191258000},"page":"27-38","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":48,"title":["Differential sensitivities to lactate transport inhibitors of breast cancer cell lines"],"prefix":"10.1530","volume":"21","author":[{"given":"Filipa","family":"Morais-Santos","sequence":"first","affiliation":[]},{"given":"Vera","family":"Miranda-Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"S\u00edlvia","family":"Pinheiro","sequence":"additional","affiliation":[]},{"given":"Andr\u00e9 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