{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T19:17:59Z","timestamp":1774379879593,"version":"3.50.1"},"reference-count":47,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>Prostate cancer (PCa), a leading cause of cancer-related morbidity and mortality, arises through the acquisition of genetic and epigenetic alterations. Deregulation of histone methyltransferases (HMTs) or demethylases (HDMs) has been associated with PCa development and progression. However, the precise influence of altered HMTs or HDMs expression and respective histone marks in PCa onset and progression remains largely unknown. To clarify the role of HMTs and HDMs in prostate carcinogenesis, expression levels of 37 HMTs and 20 HDMs were assessed in normal prostate and PCa tissue samples by RT-qPCR.<jats:italic>SMYD3<\/jats:italic>,<jats:italic>SUV39H2<\/jats:italic>,<jats:italic>PRMT6<\/jats:italic>,<jats:italic>KDM5A<\/jats:italic>, and<jats:italic>KDM6A<\/jats:italic>were upregulated, whereas<jats:italic>KMT2A-E (MLL1-5)<\/jats:italic>and<jats:italic>KDM4B<\/jats:italic>were downregulated in PCa, compared with normal prostate tissues. Remarkably,<jats:italic>PRMT6<\/jats:italic>was the histone modifier that best discriminated normal from tumorous tissue samples. Interestingly,<jats:italic>EZH2<\/jats:italic>and<jats:italic>SMYD3<\/jats:italic>expression levels significantly correlated with less differentiated and more aggressive tumors. Remarkably,<jats:italic>SMYD3<\/jats:italic>expression levels were of independent prognostic value for the prediction of disease-specific survival of PCa patients with clinically localized disease submitted to radical prostatectomy. We concluded that expression profiling of HMTs and HDMs, especially<jats:italic>SMYD3<\/jats:italic>, might be of clinical usefulness for the assessment of PCa patients and assist in pre-therapeutic decision-making.<\/jats:p>","DOI":"10.1530\/erc-13-0375","type":"journal-article","created":{"date-parts":[[2013,11,8]],"date-time":"2013-11-08T01:22:42Z","timestamp":1383873762000},"page":"51-61","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":84,"title":["Deregulated expression of selected histone methylases and demethylases in prostate carcinoma"],"prefix":"10.1530","volume":"21","author":[{"given":"Filipa Quintela","family":"Vieira","sequence":"first","affiliation":[]},{"given":"Pedro","family":"Costa-Pinheiro","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o","family":"Ramalho-Carvalho","sequence":"additional","affiliation":[]},{"given":"Andreia","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Francisco Duarte","family":"Menezes","sequence":"additional","affiliation":[]},{"given":"Lu\u00eds","family":"Antunes","sequence":"additional","affiliation":[]},{"given":"Isa","family":"Carneiro","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Rui","family":"Henrique","sequence":"additional","affiliation":[]},{"given":"Carmen","family":"Jer\u00f3nimo","sequence":"additional","affiliation":[]}],"member":"416","reference":[{"issue":"1","key":"1_11038327","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1053\/hupa.2001.21135","volume":"32","author":"Allsbrook","year":"2001","journal-title":"Human pathology","ISSN":"https:\/\/id.crossref.org\/issn\/0046-8177","issn-type":"print"},{"key":"2_41591260","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1111\/j.1742-4658.2010.07606.x","volume":"277","year":"2010","journal-title":"FEBS JOURNAL"},{"issue":"10","key":"3_38107350","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.1158\/1055-9965.EPI-10-0555","volume":"19","year":"2010","journal-title":"Cancer Epidemiology Biomarkers &amp; Prevention","ISSN":"https:\/\/id.crossref.org\/issn\/1055-9965","issn-type":"print"},{"key":"4_47092730","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.3390\/cancers3011383","volume":"3","year":"2011","journal-title":"Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"issue":"8","key":"5_18144867","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1002\/rcm.1421","volume":"18","author":"Brame","year":"2004","journal-title":"Rapid Communications in Mass Spectrometry","ISSN":"https:\/\/id.crossref.org\/issn\/1097-0231","issn-type":"print"},{"issue":"5849","key":"6_29723838","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1126\/science.1145801","volume":"318","author":"Chang","year":"2007","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"key":"7_47092731","doi-asserted-by":"crossref","first-page":"5718","DOI":"10.3748\/wjg.v13.i43.5718","volume":"13","year":"2007","journal-title":"WORLD JOURNAL OF GASTROENTEROLOGY"},{"issue":"7","key":"8_37578631","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nrc2876","volume":"10","author":"Chi","year":"2010","journal-title":"Nature reviews. 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